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Dual Crosslinked Methacrylated Alginate Hydrogel Micron Fibers and Tissue Constructs for Cell Biology

Key Laboratory of Textile Science and Technology of the Ministry of Education, College of Textiles, Donghua University, Shanghai 201620, China
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Mar. Drugs 2019, 17(10), 557; https://doi.org/10.3390/md17100557
Received: 10 August 2019 / Revised: 18 September 2019 / Accepted: 26 September 2019 / Published: 28 September 2019
As an important natural polysaccharide biomaterial from marine organisms, alginate and its derivatives have shown great potential in the fabrication of biomedical materials such as tissue engineering, cell biology, drug delivery, and pharmaceuticals due to their excellent biological activity and controllable physicochemical properties. Ionic crosslinking is the most common method used in the preparation of alginate-based biomaterials, but ionic crosslinked alginate hydrogels are prone to decompose in physiological solution, which hinders their applications in biomedical fields. In this study, dual crosslinked alginate hydrogel microfibers were prepared for the first time. The ionic crosslinked methacrylated alginate (Alg-MA) hydrogel microfibers fabricated by Microfluidic Fabrication (MFF) system were exposed to ultraviolet (UV) light and covalent crosslink between methacrylate groups avoided the fracture of dual crosslinked macromolecular chains in organizational environment. The chemical structures, swelling ratio, mechanical performance, and stability were investigated. Cell-encapsulated dual crosslinked Alg-MA hydrogel microfibers were fabricated to explore the application in tissue engineering for the first time. The hydrogel microfibers provided an excellent 3D distribution and growth conditions for cells. Cell-encapsulated Alg-MA microfibers scaffolds with functional 3D tissue structures were developed which possessed great potential in the production of next-generation scaffolds for tissue engineering and regenerative medicine. View Full-Text
Keywords: alginate; methacrylation; microfluidic fabrication; dual crosslinking; cell-encapsulated; biological microfibers assemblies; marine biomaterial alginate; methacrylation; microfluidic fabrication; dual crosslinking; cell-encapsulated; biological microfibers assemblies; marine biomaterial
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Gao, Y.; Jin, X. Dual Crosslinked Methacrylated Alginate Hydrogel Micron Fibers and Tissue Constructs for Cell Biology. Mar. Drugs 2019, 17, 557.

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