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Mar. Drugs 2018, 16(9), 326; https://doi.org/10.3390/md16090326

Bacillamidins A–G from a Marine-Derived Bacillus pumilus

1
Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Ministry of Education), College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China
2
Department of Chemistry, University of British Columbia, Vancouver, BC V6T1Z1, Canada
3
School of Life Sciences, Southwest University, Chongqing 400715, China
*
Author to whom correspondence should be addressed.
Received: 20 August 2018 / Revised: 7 September 2018 / Accepted: 7 September 2018 / Published: 11 September 2018
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Abstract

Seven long-chain amides, including five previously undescribed bacillamidins A–E (15) and two previously reported synthetic analogs, bacillamidins F (6) and G (7), were isolated from extracts of the marine-derived Bacillus pumilus strain RJA1515. The structures of the new compounds were established by extensive analysis of 1D and 2D nuclear magnetic resonance (NMR) data as well as high resolution mass spectrometry (HRMS), and the absolute configurations of the stereogenic carbons of 14 were established by comparison of the calculated and the experimental electronic circular dichroism (ECD) spectra. The cytotoxic and antimicrobial activities of 17 were evaluated. View Full-Text
Keywords: Bacillus pumilus; long-chain amides; cytotoxic activity; antimicrobial activity Bacillus pumilus; long-chain amides; cytotoxic activity; antimicrobial activity
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Zhou, S.-Y.; Hu, Y.-J.; Meng, F.-C.; Qu, S.-Y.; Wang, R.; Andersen, R.J.; Liao, Z.-H.; Chen, M. Bacillamidins A–G from a Marine-Derived Bacillus pumilus. Mar. Drugs 2018, 16, 326.

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