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Molecular Targets of Active Anticancer Compounds Derived from Marine Sources

Key Laboratory of Marine Drugs of Minister of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266071, China
Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, China
Author to whom correspondence should be addressed.
Mar. Drugs 2018, 16(5), 175;
Received: 10 March 2018 / Revised: 14 May 2018 / Accepted: 17 May 2018 / Published: 22 May 2018
(This article belongs to the Special Issue Marine Drugs Interact with Functional Proteins)
PDF [1830 KB, uploaded 22 May 2018]


Over the past decades, a number of novel compounds, which are produced in the marine environment, have been found to exhibit the anticancer effects. This review focuses on molecular targets of marine-derived anticancer candidates in clinical and preclinical studies. They are kinases, transcription factors, histone deacetylase, the ubiquitin-proteasome system, and so on. Specific emphasis of this review paper is to provide information on the optimization of new target compounds for future research and development of anticancer drugs, based on the identification of structures of these target molecules and parallel compounds. View Full-Text
Keywords: marine sources; anticancer compounds; molecular targets marine sources; anticancer compounds; molecular targets

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Song, X.; Xiong, Y.; Qi, X.; Tang, W.; Dai, J.; Gu, Q.; Li, J. Molecular Targets of Active Anticancer Compounds Derived from Marine Sources. Mar. Drugs 2018, 16, 175.

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