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Mar. Drugs 2018, 16(4), 106;

A Potential Adjuvant Agent of Chemotherapy: Sepia Ink Polysaccharides

College of Chemistry & Environment, Guangdong Ocean University, Zhanjiang 524088, China
Author to whom correspondence should be addressed.
Received: 18 January 2018 / Revised: 19 March 2018 / Accepted: 25 March 2018 / Published: 28 March 2018
(This article belongs to the Collection Marine Compounds and Cancer)
PDF [247 KB, uploaded 3 May 2018]


Sepia ink polysaccharide (SIP) isolated from squid and cuttlefish ink is a kind of acid mucopolysaccharide that has been identified in three types of primary structures from squid (Illex argentinus and Ommastrephes bartrami), cuttlefish Sepiella maindroni, and cuttlefish Sepia esculenta ink. Although SIP has been proved to be multifaceted, most of the reported evidence has illuminated its chemopreventive and antineoplastic activities. As a natural product playing a role in cancer treatment, SIP may be used as chemotherapeutic ancillary agent or functional food. Based on the current findings on SIP, we have summarized four topics in this review, including: chemopreventive, antineoplastic, chemosensitive, and procoagulant and anticoagulant activities, which are correlative closely with the actions of anticancer agents on cancer patients, such as anticancer, toxicity and thrombogenesis, with the latter two actions being common causes of death in cancer cases exposed to chemotherapeutic agents. View Full-Text
Keywords: Sepia ink polysaccharides; chemoprevention; antitumour; chemosensitization; anticoagulation Sepia ink polysaccharides; chemoprevention; antitumour; chemosensitization; anticoagulation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Li, F.; Luo, P.; Liu, H. A Potential Adjuvant Agent of Chemotherapy: Sepia Ink Polysaccharides. Mar. Drugs 2018, 16, 106.

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