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Open AccessArticle

Dichloroisocoumarins with Potential Anti-Inflammatory Activity from the Mangrove Endophytic Fungus Ascomycota sp. CYSK-4

1
School of Marine Sciences, Sun Yat-sen University, Guangzhou 510006, China
2
School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China
3
School of Pharmacy, Guangdong Medical University, Dongguan 523808, China
4
South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center, Sun Yat-Sen University, Guangzhou 510275, China
*
Authors to whom correspondence should be addressed.
Mar. Drugs 2018, 16(2), 54; https://doi.org/10.3390/md16020054
Received: 18 December 2017 / Revised: 26 January 2018 / Accepted: 2 February 2018 / Published: 9 February 2018
(This article belongs to the Special Issue Marine Natural Products from Symbiotic Ecosystems)
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Abstract

Three new isocoumarins—dichlorodiaportintone (1), desmethyldichlorodiaportintone (2) and desmethyldichlorodiaportinol (3)—as well as six known analogues (4–9) were isolated from the culture of the mangrove endophytic fungus Ascomycota sp. CYSK-4 from Pluchea indica. Their structures were elucidated by analysis of spectroscopic data. The absolute configuration of compounds 1 and 2 were determined by the modified Mosher’s method. Compound 2 showed significant anti-inflammatory activity by inhibiting the production of NO in LPS-induced RAW 264.7 cells with IC50 value of 15.8 μM, while compounds 1, 5, and 6 exhibited weak activities with IC50 values of 41.5, 33.6, and 67.2 μM, respectively. In addition, compounds 1, 5, and 6 showed antibacterial effects against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Klebsiella pneumoniae, and Acinetobacter calcoaceticus with the MIC values in the range of 25–50 μg·mL−1. View Full-Text
Keywords: isocoumarin; endophytic fungus; Pluchea indica; Ascomycota sp.; anti-inflammatory; antibacterial isocoumarin; endophytic fungus; Pluchea indica; Ascomycota sp.; anti-inflammatory; antibacterial
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Chen, Y.; Liu, Z.; Liu, H.; Pan, Y.; Li, J.; Liu, L.; She, Z. Dichloroisocoumarins with Potential Anti-Inflammatory Activity from the Mangrove Endophytic Fungus Ascomycota sp. CYSK-4. Mar. Drugs 2018, 16, 54.

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