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Mar. Drugs 2018, 16(11), 438; https://doi.org/10.3390/md16110438

Anti-MRSA Sesquiterpenes from the Semi-Mangrove Plant Myoporum bontioides A. Gray

1
State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources/Guangdong Key Laboratory for Innovative Development and Utilization of Forest Plant Germplasm, College of Forestry and Landscape Architecture, South China Agricultural University, Guangzhou 510642, China
2
College of Materials and Energy, South China Agricultural University, Guangzhou 510642, China
3
Guangdong Provincial Key Laboratory of Bio-control for the Forest Disease and Pest, Guangdong Academy of Forestry, Guangzhou 510520, China
4
Key Laboratory of Functional Foods, Ministry of Agriculture/Guangdong Key Laboratory of Agricultural Products Processing/Sericultural & Agri-Food Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou 510610, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 15 October 2018 / Revised: 31 October 2018 / Accepted: 5 November 2018 / Published: 8 November 2018
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Abstract

The striking rise of methicillin-resistant Staphylococcus aureus (MRSA) infections has become a serious threat to public health worldwide. In an effort to search for new anti-MRSA agents from natural products, a bioassay-guided phytochemical study was conducted on the semi-mangrove plant Myoporum bontioides A. Gray, which led to the isolation of two new sesquiterpene alkaloids (1 and 2) and six known furanosesquiterpenes (38). Their structures were elucidated on the basis of extensive analysis of their 1D, 2D NMR and mass spectroscopic data. These two new alkaloids (1 and 2) displayed potent anti-MRSA activity with MIC value of 6.25 μg/mL. This is the first report of sesquiterpene alkaloids from the plants of Myoporum genus and their anti-MRSA activity. View Full-Text
Keywords: Myoporum bontioides; methicillin-resistant Staphylococcus aureus (MRSA); sesquiterpene alkaloids Myoporum bontioides; methicillin-resistant Staphylococcus aureus (MRSA); sesquiterpene alkaloids
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Dong, L.-M.; Huang, L.-L.; Dai, H.; Xu, Q.-L.; Ouyang, J.-K.; Jia, X.-C.; Gu, W.-X.; Tan, J.-W. Anti-MRSA Sesquiterpenes from the Semi-Mangrove Plant Myoporum bontioides A. Gray. Mar. Drugs 2018, 16, 438.

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