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Mar. Drugs 2018, 16(11), 416;

A Novel Complex of Chitosan–Sodium Carbonate and Its Properties

School of Pharmaceutical Science, Jiangnan University, Wuxi 214122, China
College of Chemistry, Chemical Engineering and Materials Science, Testing and Analysis Center, Soochow University, Suzhou 215123, China
Authors to whom correspondence should be addressed.
Received: 18 September 2018 / Revised: 23 October 2018 / Accepted: 26 October 2018 / Published: 30 October 2018
(This article belongs to the Special Issue Marine Chitin 2019)
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Chitosan has excellent properties, as it is nontoxic, mucoadhesive, biocompatible, and biodegradable. However, the poor water solubility of chitosan is a major disadvantage. Here, a novel chitosan-sodium carbonate complex was formed by adding a large amount of sodium carbonate to a chitosan/acetic acid solution, which is water-soluble. Fourier transform infrared spectroscopy, energy dispersive spectrometry, scanning electron microscopy, and solid-state nuclear magnetic resonance techniques were used to detect and characterize the aforementioned complex, which appeared to be a neat flake crystal. Solid-state nuclear magnetic resonance (SSNMR) was used to verify the connections between carbonate, sodium ions, and the protonated amino group in chitosan on the basis of 13C signals at the chemical shift of 167.745 ppm and 164.743 ppm. Further confirmation was provided by the strong cross-polarization signals identified by the SSNMR 2D 13C–1H frequency-switched Lee–Goldberg heteronuclear correlation spectrum. The cytotoxicity of a film prepared using this complex was tested using rat fibroblasts. The results show that the film promoted cell proliferation, which provides evidence to support its nontoxicity. The ease of film-forming and the results of cytocompatibility testing suggest that the chitosan-sodium carbonate complex has the potential for use in tissue engineering. View Full-Text
Keywords: chitosan; cytotoxicity; polymer film; sodium carbonate; soluble chitosan complex chitosan; cytotoxicity; polymer film; sodium carbonate; soluble chitosan complex

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Qian, J.; Wang, X.; Shu, J.; Su, C.; Gong, J.; Xu, Z.; Jin, J.; Shi, J. A Novel Complex of Chitosan–Sodium Carbonate and Its Properties. Mar. Drugs 2018, 16, 416.

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