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Mar. Drugs 2018, 16(10), 357; https://doi.org/10.3390/md16100357

Chrysoxanthones A–C, Three New Xanthone–Chromanone Heterdimers from Sponge-Associated Penicillium chrysogenum HLS111 Treated with Histone Deacetylase Inhibitor

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Key Laboratory of Biosynthesis of Natural Products of National Health Committee, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, China
These authors contributed equally to this work.
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Received: 11 September 2018 / Revised: 26 September 2018 / Accepted: 28 September 2018 / Published: 1 October 2018
(This article belongs to the Special Issue Genome Mining and Marine Microbial Natural Products)
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Abstract

By treating with histone-deacetylase inhibitor valproate sodium, three new heterdimeric tetrahydroxanthone–chromanone lactones chrysoxanthones A–C (13), along with 17 known compounds were isolated from a sponge-associated Penicillium chrysogenum HLS111. The planar structures of chrysoxanthones A–C were elucidated by means of spectroscopic analyses, including MS, 1D, and 2D NMR. Their absolute configurations were established by electronic circular dichroism (ECD) calculations. Chrysoxanthones A–C exhibited moderate antibacterial activities against Bacillus subtilis with minimum inhibitory concentration (MIC) values of 5–10 μg/mL. View Full-Text
Keywords: Penicillium chrysogenum; secondary metabolites; histone-deacetylase inhibitor; antibacterial activity; polyketide synthase Penicillium chrysogenum; secondary metabolites; histone-deacetylase inhibitor; antibacterial activity; polyketide synthase
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Zhen, X.; Gong, T.; Wen, Y.-H.; Yan, D.-J.; Chen, J.-J.; Zhu, P. Chrysoxanthones A–C, Three New Xanthone–Chromanone Heterdimers from Sponge-Associated Penicillium chrysogenum HLS111 Treated with Histone Deacetylase Inhibitor. Mar. Drugs 2018, 16, 357.

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