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Mar. Drugs 2018, 16(10), 347; https://doi.org/10.3390/md16100347

Marine Peroxy Sesquiterpenoids Induce Apoptosis by Modulation of Nrf2-ARE Signaling in HCT116 Colon Cancer Cells

1
Department Bioresource Technology, Okinawa National College of Technology, 905 Henoko, Nago-city Okinawa Prefecture 905-2192, Japan
2
Department of Chemistry, Biology and Marine Science, University of the Ryukyus, 1 Senbaru, Nishihara-cho, Okinawa 903-2013, Japan
*
Author to whom correspondence should be addressed.
Received: 6 September 2018 / Revised: 14 September 2018 / Accepted: 19 September 2018 / Published: 23 September 2018
(This article belongs to the Special Issue Marine Natural Products Discovery: In Honor of Late Prof. Tatsuo Higa)
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Abstract

Our current study demonstrated that the marine peroxy sesquiterpenoids isolated from the Okinawan soft coral Sinularia sp. have an antitumor activity in human colon cancer cell (HCT) 116 colon cancer cells with their induction of apoptosis due to H2O2 production derived from the compounds. This study clarified that peroxy sesquiterpenoids (1 and 2) inhibited anti-apoptosis proteins, such as B-cell lymphoma-extra large (Bcl-xL) and phosphoAkt (pAkt). In addition, the heme oxygenase-1 (HO-1), nuclear factor-erythroid-2-related factor (Nrf2), and phosphoNrf2 (pNrf2) proteins related to the cell survival regulation signal of Nrf2-ARE (antioxidant response element) were also suppressed in the presence of these compounds. While the cells treated with the compounds and trolox as an antioxidant expressed the inhibited proteins, such as HO-1, Nrf2, and Bcl-xL, it was suggested that the H2O2 involving free radical reactions derived from the molecule would be a trigger of apoptosis with the modulation of Nrf2-ARE signaling in the cells. View Full-Text
Keywords: free radical; peroxy sesquiterpenoid; apoptosis; Nrf2-ARE signaling; HCT116 colon cancer cells; soft coral; Sinularia sp. free radical; peroxy sesquiterpenoid; apoptosis; Nrf2-ARE signaling; HCT116 colon cancer cells; soft coral; Sinularia sp.
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Taira, J.; Miyazato, H.; Ueda, K. Marine Peroxy Sesquiterpenoids Induce Apoptosis by Modulation of Nrf2-ARE Signaling in HCT116 Colon Cancer Cells. Mar. Drugs 2018, 16, 347.

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