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Antifouling Compounds from Marine Macroalgae

by Hans Uwe Dahms 1,2,3 and Sergey Dobretsov 4,5,*
Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, No. 100, Shin-Chuan 1st Road, Kaohsiung 80708, Taiwan
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, No. 70, Lienhai Road, Kaohsiung 80424, Taiwan
Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
Center of Excellence in Marine Biotechnology, Sultan Qaboos University, Muscat 123, Oman
Department of Marine Science and Fisheries, College of Agricultural and Marine Sciences, Sultan Qaboos University, Muscat 123, Oman
Author to whom correspondence should be addressed.
Mar. Drugs 2017, 15(9), 265;
Received: 30 March 2017 / Revised: 29 June 2017 / Accepted: 12 July 2017 / Published: 28 August 2017
(This article belongs to the Special Issue Antifouling Marine Natural Products)
Marine macroalgae produce a wide variety of biologically-active metabolites that have been developed into commercial products, such as antibiotics, immunosuppressive, anti-inflammatory, cytotoxic agents, and cosmetic products. Many marine algae remain clean over longer periods of time, suggesting their strong antifouling potential. Isolation of biogenic compounds and the determination of their structure could provide leads for the development of environmentally-friendly antifouling paints. Isolated substances with potent antifouling activity belong to fatty acids, lipopeptides, amides, alkaloids, lactones, steroids, terpenoids, and pyrroles. It is unclear as yet to what extent symbiotic microorganisms are involved in the synthesis of these compounds. Algal secondary metabolites have the potential to be produced commercially using genetic and metabolic engineering techniques. This review provides an overview of publications from 2010 to February 2017 about antifouling activity of green, brown, and red algae. Some researchers were focusing on antifouling compounds of brown macroalgae, while metabolites of green algae received less attention. Several studies tested antifouling activity against bacteria, microalgae and invertebrates, but in only a few studies was the quorum sensing inhibitory activity of marine macroalgae tested. Rarely, antifouling compounds from macroalgae were isolated and tested in an ecologically-relevant way. View Full-Text
Keywords: macroalgae; antifouling; biofouling; biogenic compounds; quorum sensing; marine natural products macroalgae; antifouling; biofouling; biogenic compounds; quorum sensing; marine natural products
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Dahms, H.U.; Dobretsov, S. Antifouling Compounds from Marine Macroalgae. Mar. Drugs 2017, 15, 265.

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