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Mar. Drugs 2017, 15(8), 260;

5-Hydroxycyclopenicillone, a New β-Amyloid Fibrillization Inhibitor from a Sponge-Derived Fungus Trichoderma sp. HPQJ-34

Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Ningbo University, Ningbo 315211, China
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA
Key Laboratory of Marine Biotechnology of Zhejiang Province, Ningbo University, Ningbo 315211, China
Ocean College, Zhejiang University, Hangzhou 310058, China
School of Medicine, Ningbo University, Ningbo 315211, China
Institute of New Drug Research and Guangzhou Key Laboratory of Innovative Chemical Drug Research in Cardio-cerebrovascular Diseases, College of Pharmacy, Jinan University, Guangzhou 510632, China
Authors to whom correspondence should be addressed.
Received: 17 May 2017 / Accepted: 16 August 2017 / Published: 19 August 2017
(This article belongs to the Special Issue Bioactive Compounds from Marine Microbes - II)
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Abstract: A new cyclopentenone, 5-hydroxycyclopeni cillone (1), was isolated together with three known compounds, ar-turmerone (2), citreoisocoumarin (3), and 6-O-methyl-citreoisocoumarin (4), from a culture of the sponge-derived fungus Trichoderma sp. HPQJ-34. The structures of 14 were characterized using comprehensive spectroscopic analyses. The absolute configuration of 1 was determined by comparison of electronic circular dichroism (ECD) spectra with literature values used for the reported analogue, cyclopenicillone (5), which was not isolated in this research. Compound 1 was shown to scavenge 2,2-diphenyl-1-picrylhydrazyl free radicals, and decrease β-amyloid (Aβ) fibrillization in vitro. Moreover, 1 significantly reduced H2O2-induced neurotoxicity in SH-SY5Y cells. These findings suggested that compound 1, a newly discovered cyclopentenone, has moderate anti-oxidative, anti-Aβ fibrillization properties and neuroprotective effects, and might be a good free radical scavenger. View Full-Text
Keywords: sponge-derived fungus; cyclopentenone; Trichoderma sp. HPQJ-34; Alzheimer’s disease sponge-derived fungus; cyclopentenone; Trichoderma sp. HPQJ-34; Alzheimer’s disease

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Fang, F.; Zhao, J.; Ding, L.; Huang, C.; Naman, C.B.; He, S.; Wu, B.; Zhu, P.; Luo, Q.; Gerwick, W.H.; Yan, X.; Wang, Q.; Zhang, Z.; Cui, W. 5-Hydroxycyclopenicillone, a New β-Amyloid Fibrillization Inhibitor from a Sponge-Derived Fungus Trichoderma sp. HPQJ-34. Mar. Drugs 2017, 15, 260.

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