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Keywords = Trichoderma sp. HPQJ-34

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12 pages, 3432 KB  
Article
5-Hydroxycyclopenicillone, a New β-Amyloid Fibrillization Inhibitor from a Sponge-Derived Fungus Trichoderma sp. HPQJ-34
by Fang Fang, Jiaying Zhao, Lijian Ding, Chunhui Huang, C. Benjamin Naman, Shan He, Bin Wu, Peng Zhu, Qijun Luo, William H. Gerwick, Xiaojun Yan, Qinwen Wang, Zaijun Zhang and Wei Cui
Mar. Drugs 2017, 15(8), 260; https://doi.org/10.3390/md15080260 - 19 Aug 2017
Cited by 32 | Viewed by 5942
Abstract
Abstract: A new cyclopentenone, 5-hydroxycyclopeni cillone (1), was isolated together with three known compounds, ar-turmerone (2), citreoisocoumarin (3), and 6-O-methyl-citreoisocoumarin (4), from a culture of the sponge-derived fungus Trichoderma sp. HPQJ-34. The [...] Read more.
Abstract: A new cyclopentenone, 5-hydroxycyclopeni cillone (1), was isolated together with three known compounds, ar-turmerone (2), citreoisocoumarin (3), and 6-O-methyl-citreoisocoumarin (4), from a culture of the sponge-derived fungus Trichoderma sp. HPQJ-34. The structures of 14 were characterized using comprehensive spectroscopic analyses. The absolute configuration of 1 was determined by comparison of electronic circular dichroism (ECD) spectra with literature values used for the reported analogue, cyclopenicillone (5), which was not isolated in this research. Compound 1 was shown to scavenge 2,2-diphenyl-1-picrylhydrazyl free radicals, and decrease β-amyloid (Aβ) fibrillization in vitro. Moreover, 1 significantly reduced H2O2-induced neurotoxicity in SH-SY5Y cells. These findings suggested that compound 1, a newly discovered cyclopentenone, has moderate anti-oxidative, anti-Aβ fibrillization properties and neuroprotective effects, and might be a good free radical scavenger. Full article
(This article belongs to the Special Issue Bioactive Compounds from Marine Microbes - II)
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