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Sterols from the Octocoral Nephthea columnaris

1,2,†, 3,4,†, 2, 5,6,7,* and 1,2,8,9,10,*
Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
Department of Neurosurgery, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan
Graduate Institute of Natural Products, College of Medicine and Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 333, Taiwan
Research Center for Chinese Herbal Medicine, Research Center for Food and Cosmetic Safety, and Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan
Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Mar. Drugs 2017, 15(7), 212;
Received: 23 May 2017 / Revised: 26 June 2017 / Accepted: 1 July 2017 / Published: 4 July 2017
(This article belongs to the Special Issue Natural Products from Coral Reef Organisms)
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Two new sterols, columnaristerols B (1) and C (2), along with two known analogues, 5,6-epoxylitosterol (3) and litosterol (4), were obtained from the octocoral Nephthea columnaris. The structures of new sterols 1 and 2 were elucidated by using spectroscopic methods and comparing the spectroscopic data with those of known related metabolites. Sterol 3 was found to suppress superoxide anion production and elastase secretion by human neutrophils. View Full-Text
Keywords: octocoral; Nephthea columnaris; columnaristerol; litosterol; superoxide anion; elastase octocoral; Nephthea columnaris; columnaristerol; litosterol; superoxide anion; elastase

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Whuang, T.-Y.; Tsai, H.-C.; Su, Y.-D.; Hwang, T.-L.; Sung, P.-J. Sterols from the Octocoral Nephthea columnaris. Mar. Drugs 2017, 15, 212.

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