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The Effect of Phloroglucinol, A Component of Ecklonia cava Extract, on Hepatic Glucose Production

by Ji-Young Yoon 1,†, Hojung Choi 1,2,† and Hee-Sook Jun 1,2,3,*
College of Pharmacy, Gachon Institute of Pharmaceutical Science, Gachon University, Yeonsu-gu, Incheon 21936, Korea
Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Yeonsu-gu, Incheon 21999, Korea
Gachon Medical Research Institute, Gil Hospital, Namdong-gu, Incheon 21565, Korea
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Keith B. Glaser
Mar. Drugs 2017, 15(4), 106;
Received: 2 February 2017 / Revised: 25 March 2017 / Accepted: 2 April 2017 / Published: 5 April 2017
Phloroglucinol is a phenolic compound that is one of the major compounds in Ecklonia cava (brown alga). It has many pharmacological activities, but its anti-diabetic effect is not yet fully explored. In this study, we investigated the effect of phloroglucinol on the control of blood glucose levels and the regulation of hepatic glucose production. Phloroglucinol significantly improved glucose tolerance in male C57BL/6J mice fed a high fat diet (HFD) and inhibited glucose production in mouse primary hepatocytes. The expression of phosphoenol pyruvate carboxykinase (PEPCK) and glucose-6-phosphatase mRNA and protein (G6Pase), enzymes involved in gluconeogenesis, were inhibited in liver tissue from phloroglucinol-treated mice and in phloroglucinol-treated HepG2 cells. In addition, phloroglucinol treatment increased phosphorylated AMP-activated protein kinase (AMPK)α in HepG2 cells. Treatment with compound C, an AMPKα inhibitor, inhibited the increase of phosphorylated AMPKα and the decrease of PEPCK and G6Pase expression caused by phloroglucinol treatment. We conclude that phloroglucinol may inhibit hepatic gluconeogenesis via modulating the AMPKα signaling pathway, and thus lower blood glucose levels. View Full-Text
Keywords: Phloroglucinol; gluconeogenesis; PEPCK; G6Pase; AMPKα Phloroglucinol; gluconeogenesis; PEPCK; G6Pase; AMPKα
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Yoon, J.-Y.; Choi, H.; Jun, H.-S. The Effect of Phloroglucinol, A Component of Ecklonia cava Extract, on Hepatic Glucose Production. Mar. Drugs 2017, 15, 106.

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