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Mar. Drugs 2017, 15(1), 2;

Pyran Rings Containing Polyketides from Penicillium raistrickii

College of Pharmacy, Binzhou Medical College, Yantai 264003, China
The Hospital of Luzhong Mining Co., Ltd., Laiwu 271113, China
Author to whom correspondence should be addressed.
Academic Editor: Orazio Taglialatela-Scafati
Received: 31 October 2016 / Revised: 14 December 2016 / Accepted: 15 December 2016 / Published: 23 December 2016
(This article belongs to the Special Issue Marine Fungal Natural Products)
PDF [1195 KB, uploaded 23 December 2016]


Five new pyran rings containing polyketides, penicipyrans A–E (15), together with the known pestapyrone A (6), were isolated from the saline soil-derived Penicillium raistrickii. Their structures were determined by interpretation of NMR and HRESIMS data. The absolute configurations of compounds 4 and 5 were established by the modified Mosher’s method and single-crystal X-ray diffraction analysis, respectively. These compounds possessed high structural diversity including two α-pyrones (1, 2), three isocoumarins (3, 4, 6), and one dihydropyran derivative (5). Among them, Compound 5 exhibited cytotoxicity against HL-60 and K562 cell lines with IC50 values of 4.4 and 8.5 μM, respectively. View Full-Text
Keywords: Penicillium raistrickii; α-pyrone; isocoumarin; polyketides; saline soil-derived fungus Penicillium raistrickii; α-pyrone; isocoumarin; polyketides; saline soil-derived fungus

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Ma, L.-Y.; Liu, D.-S.; Li, D.-G.; Huang, Y.-L.; Kang, H.-H.; Wang, C.-H.; Liu, W.-Z. Pyran Rings Containing Polyketides from Penicillium raistrickii. Mar. Drugs 2017, 15, 2.

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