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Cytoglobosins H and I, New Antiproliferative Cytochalasans from Deep-Sea-Derived Fungus Chaetomium globosum

Integrative Microbiology Research Centre, College of Agriculture, South China Agricultural University, Guangzhou 510642, China
Pharmaceutical Research Center, School of Pharmacology, Guangzhou Medical University, Guangzhou 510182, China
Guangdong Innovative and Entrepreneurial Research Team of Sociomicrobiology Basic Science and Frontier Technology, South China Agricultural University, Guangzhou 510642, China
State Key Laboratory Breeding Base of Marine Genetic Resources, Third Institute of Oceanography, State Oceanic Administration, Key Laboratory of Marine Genetic Resources of Fujian Province, Xiamen 361005, China
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Orazio Taglialatela-Scafati
Mar. Drugs 2016, 14(12), 233;
Received: 4 November 2016 / Revised: 13 December 2016 / Accepted: 14 December 2016 / Published: 20 December 2016
(This article belongs to the Special Issue Marine Fungal Natural Products)
PDF [2349 KB, uploaded 20 December 2016]


Cytoglobosins H (1) and I (2), together with seven known cytochalasan alkaloids (39), were isolated from the deep-sea-derived fungus Chaetomium globosum. The structures of new compounds 1 and 2 were elucidated by extensive 1D and 2D NMR and mass spectroscopic data. All the compounds were evaluated for their antiproliferative activities against MDA-MB-231 human breast cancer cells, LNCaP human prostate cancer cells, and B16F10 mouse melanoma cells. Compound 6 showed significant antiproliferative activity against LNCaP and B16F10 cell lines with IC50 values of 0.62 and 2.78 μM, respectively. Further testing confirmed that compound 6 inhibited the growth of LNCaP cells by inducing apoptosis. View Full-Text
Keywords: cytochalasans; fungus; antiproliferative activity cytochalasans; fungus; antiproliferative activity

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Zhang, Z.; Min, X.; Huang, J.; Zhong, Y.; Wu, Y.; Li, X.; Deng, Y.; Jiang, Z.; Shao, Z.; Zhang, L.; He, F. Cytoglobosins H and I, New Antiproliferative Cytochalasans from Deep-Sea-Derived Fungus Chaetomium globosum. Mar. Drugs 2016, 14, 233.

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