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Toxicological Evaluation of Low Molecular Weight Fucoidan in Vitro and in Vivo

Department of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung 20246, Taiwan
Cancer Center, Wan Fang Hospital, Taipei Medical University, Taipei 11696, Taiwan
Department of Food Science, National Taiwan Ocean University, Keelung 20246, Taiwan
Graduate Institute of Biotechnology, Chinese Culture University, Taipei 11114, Taiwan
Author to whom correspondence should be addressed.
Academic Editor: Paola Laurienzo
Mar. Drugs 2016, 14(7), 121;
Received: 25 April 2016 / Revised: 12 June 2016 / Accepted: 17 June 2016 / Published: 24 June 2016
(This article belongs to the Collection Marine Polysaccharides)
PDF [416 KB, uploaded 24 June 2016]


For a long time, fucoidan has been well known for its pharmacological activities, and recently low molecular weight fucoidan (LMF) has been used in food supplements and pharmaceutical products. In the present study, LMF was extracted from Laminaria japonica by enzyme hydrolysis. The toxicity of LMF in mouse and rat models was determined by many methods, such as total arsenic content, bacterial reverse mutation assay, chromosome aberration assay, and in vivo micronucleus assay. The present findings showed that LMF at 5000 μg/mL exhibited no mutagenicity. It also produced no formatting disruption of red blood cells in vivo. At 2000 mg/kg BW/day there were no toxicological indications. LMF is expected to be used as a safe food supplement. View Full-Text
Keywords: low molecular weight fucoidan; toxicity; Laminaria japonica low molecular weight fucoidan; toxicity; Laminaria japonica

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Hwang, P.-A.; Yan, M.-D.; Lin, H.-T.V.; Li, K.-L.; Lin, Y.-C. Toxicological Evaluation of Low Molecular Weight Fucoidan in Vitro and in Vivo. Mar. Drugs 2016, 14, 121.

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