Next Article in Journal
Pretrichodermamides D–F from a Marine Algicolous Fungus Penicillium sp. KMM 4672
Next Article in Special Issue
Electrospinning of Nanodiamond-Modified Polysaccharide Nanofibers with Physico-Mechanical Properties Close to Natural Skins
Previous Article in Journal
A Review on the Valorization of Macroalgal Wastes for Biomethane Production
Previous Article in Special Issue
Effect of Experimental Parameters on Alginate/Chitosan Microparticles for BCG Encapsulation
Open AccessArticle

Toxicological Evaluation of Low Molecular Weight Fucoidan in Vitro and in Vivo

1
Department of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung 20246, Taiwan
2
Cancer Center, Wan Fang Hospital, Taipei Medical University, Taipei 11696, Taiwan
3
Department of Food Science, National Taiwan Ocean University, Keelung 20246, Taiwan
4
Graduate Institute of Biotechnology, Chinese Culture University, Taipei 11114, Taiwan
*
Author to whom correspondence should be addressed.
Academic Editor: Paola Laurienzo
Mar. Drugs 2016, 14(7), 121; https://doi.org/10.3390/md14070121
Received: 25 April 2016 / Revised: 12 June 2016 / Accepted: 17 June 2016 / Published: 24 June 2016
(This article belongs to the Collection Marine Polysaccharides)
For a long time, fucoidan has been well known for its pharmacological activities, and recently low molecular weight fucoidan (LMF) has been used in food supplements and pharmaceutical products. In the present study, LMF was extracted from Laminaria japonica by enzyme hydrolysis. The toxicity of LMF in mouse and rat models was determined by many methods, such as total arsenic content, bacterial reverse mutation assay, chromosome aberration assay, and in vivo micronucleus assay. The present findings showed that LMF at 5000 μg/mL exhibited no mutagenicity. It also produced no formatting disruption of red blood cells in vivo. At 2000 mg/kg BW/day there were no toxicological indications. LMF is expected to be used as a safe food supplement. View Full-Text
Keywords: low molecular weight fucoidan; toxicity; Laminaria japonica low molecular weight fucoidan; toxicity; Laminaria japonica
Show Figures

Graphical abstract

MDPI and ACS Style

Hwang, P.-A.; Yan, M.-D.; Lin, H.-T.V.; Li, K.-L.; Lin, Y.-C. Toxicological Evaluation of Low Molecular Weight Fucoidan in Vitro and in Vivo. Mar. Drugs 2016, 14, 121. https://doi.org/10.3390/md14070121

AMA Style

Hwang P-A, Yan M-D, Lin H-TV, Li K-L, Lin Y-C. Toxicological Evaluation of Low Molecular Weight Fucoidan in Vitro and in Vivo. Marine Drugs. 2016; 14(7):121. https://doi.org/10.3390/md14070121

Chicago/Turabian Style

Hwang, Pai-An; Yan, Ming-De; Lin, Hong-Ting V.; Li, Kuan-Lun; Lin, Yen-Chang. 2016. "Toxicological Evaluation of Low Molecular Weight Fucoidan in Vitro and in Vivo" Mar. Drugs 14, no. 7: 121. https://doi.org/10.3390/md14070121

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop