Toxicological Evaluation of Low Molecular Weight Fucoidan in Vitro and in Vivo
1
Department of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung 20246, Taiwan
2
Cancer Center, Wan Fang Hospital, Taipei Medical University, Taipei 11696, Taiwan
3
Department of Food Science, National Taiwan Ocean University, Keelung 20246, Taiwan
4
Graduate Institute of Biotechnology, Chinese Culture University, Taipei 11114, Taiwan
*
Author to whom correspondence should be addressed.
Academic Editor: Paola Laurienzo
Mar. Drugs 2016, 14(7), 121; https://doi.org/10.3390/md14070121
Received: 25 April 2016 / Revised: 12 June 2016 / Accepted: 17 June 2016 / Published: 24 June 2016
(This article belongs to the Collection Marine Polysaccharides)
For a long time, fucoidan has been well known for its pharmacological activities, and recently low molecular weight fucoidan (LMF) has been used in food supplements and pharmaceutical products. In the present study, LMF was extracted from Laminaria japonica by enzyme hydrolysis. The toxicity of LMF in mouse and rat models was determined by many methods, such as total arsenic content, bacterial reverse mutation assay, chromosome aberration assay, and in vivo micronucleus assay. The present findings showed that LMF at 5000 μg/mL exhibited no mutagenicity. It also produced no formatting disruption of red blood cells in vivo. At 2000 mg/kg BW/day there were no toxicological indications. LMF is expected to be used as a safe food supplement.
View Full-Text
Keywords:
low molecular weight fucoidan; toxicity; Laminaria japonica
▼
Show Figures
Graphical abstract
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Hwang, P.-A.; Yan, M.-D.; Lin, H.-T.V.; Li, K.-L.; Lin, Y.-C. Toxicological Evaluation of Low Molecular Weight Fucoidan in Vitro and in Vivo. Mar. Drugs 2016, 14, 121. https://doi.org/10.3390/md14070121
AMA Style
Hwang P-A, Yan M-D, Lin H-TV, Li K-L, Lin Y-C. Toxicological Evaluation of Low Molecular Weight Fucoidan in Vitro and in Vivo. Marine Drugs. 2016; 14(7):121. https://doi.org/10.3390/md14070121
Chicago/Turabian StyleHwang, Pai-An; Yan, Ming-De; Lin, Hong-Ting V.; Li, Kuan-Lun; Lin, Yen-Chang. 2016. "Toxicological Evaluation of Low Molecular Weight Fucoidan in Vitro and in Vivo" Mar. Drugs 14, no. 7: 121. https://doi.org/10.3390/md14070121
Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.
Search more from Scilit
