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Mar. Drugs 2016, 14(7), 122;

Pretrichodermamides D–F from a Marine Algicolous Fungus Penicillium sp. KMM 4672

G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Prospect 100-letiya Vladivostoka, 159, Vladivostok 690022, Russia
School of Natural Science, Far Eastern Federal University, Sukhanova St., 8, Vladivostok 690000, Russia
Laboratory of Experimantal Oncology, Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumorzentrum, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany
Author to whom correspondence should be addressed.
Academic Editor: Vassilios Roussis
Received: 14 April 2016 / Revised: 6 June 2016 / Accepted: 8 June 2016 / Published: 27 June 2016
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Three new epidithiodiketopiperazines pretrichodermamides D–F (13), together with the known N-methylpretrichodermamide B (4) and pretrichodermamide С (5), were isolated from the lipophilic extract of the marine algae-derived fungus Penicillium sp. KMM 4672. The structures of compounds 15 were determined based on spectroscopic methods. The absolute configuration of pretrichodermamide D (1) was established by a combination of modified Mosher′s method, NOESY data, and biogenetic considerations. N-Methylpretrichodermamide B (5) showed strong cytotoxicity against 22Rv1 human prostate cancer cells resistant to androgen receptor targeted therapies. View Full-Text
Keywords: marine-derived fungus; secondary metabolites; diketopiperazine; oxazadecaline; cytotoxicity marine-derived fungus; secondary metabolites; diketopiperazine; oxazadecaline; cytotoxicity

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Yurchenko, A.N.; Smetanina, O.F.; Ivanets, E.V.; Kalinovsky, A.I.; Khudyakova, Y.V.; Kirichuk, N.N.; Popov, R.S.; Bokemeyer, C.; von Amsberg, G.; Chingizova, E.A.; Afiyatullov, S.S.; Dyshlovoy, S.A. Pretrichodermamides D–F from a Marine Algicolous Fungus Penicillium sp. KMM 4672. Mar. Drugs 2016, 14, 122.

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