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Mar. Drugs 2016, 14(6), 111;

Cembranoids from a Chinese Collection of the Soft Coral Lobophytum crassum

School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China
The Fifth Affiliated Hospital, Wenzhou Medical University, Lishui 323000, China
Key Laboratory of Marine Bio-Resources Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China
Molecular Targets Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702-1201, USA
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Academic Editor: Kirsten Benkendorff
Received: 25 April 2016 / Revised: 19 May 2016 / Accepted: 23 May 2016 / Published: 3 June 2016
(This article belongs to the Collection Bioactive Compounds from Marine Invertebrates)
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Ten new cembrane-based diterpenes, locrassumins A–G (17), (–)-laevigatol B (8), (–)-isosarcophine (9), and (–)-7R,8S-dihydroxydeepoxysarcophytoxide (10), were isolated from a South China Sea collection of the soft coral Lobophytum crassum, together with eight known analogues (1118). The structures of the new compounds were determined by extensive spectroscopic analysis and by comparison with previously reported data. Locrassumin C (3) possesses an unprecedented tetradecahydrobenzo[3,4]cyclobuta[1,2][8]annulene ring system. Compounds 1, 7, 12, 13, and 17 exhibited moderate inhibition against lipopolysaccharide (LPS)-induced nitric oxide (NO) production with IC50 values of 8–24 μM. View Full-Text
Keywords: soft coral; Lobophytum crassum; cembrane-based diterpenes; NO inhibition soft coral; Lobophytum crassum; cembrane-based diterpenes; NO inhibition

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Zhao, M.; Cheng, S.; Yuan, W.; Xi, Y.; Li, X.; Dong, J.; Huang, K.; Gustafson, K.R.; Yan, P. Cembranoids from a Chinese Collection of the Soft Coral Lobophytum crassum. Mar. Drugs 2016, 14, 111.

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