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Preclinical and Clinical Studies on Antioxidative, Antihypertensive and Cardioprotective Effect of Marine Proteins and Peptides—A Review

Norwegian College of Fishery Science, Faculty of Biosciences, Fisheries and Economics, UIT The Arctic University of Norway, N-9037 Tromsø, Norway
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Academic Editor: Se-Kwon Kim
Mar. Drugs 2016, 14(11), 211; https://doi.org/10.3390/md14110211
Received: 3 October 2016 / Revised: 10 November 2016 / Accepted: 11 November 2016 / Published: 18 November 2016
(This article belongs to the Special Issue Marine Proteins and Peptides)
High seafood consumption has traditionally been linked to a reduced risk of cardiovascular diseases, mainly due to the lipid lowering effects of the long chained omega 3 fatty acids. However, fish and seafood are also excellent sources of good quality proteins and emerging documentation show that, upon digestion, these proteins are sources for bioactive peptides with documented favorable physiological effects such as antioxidative, antihypertensive and other cardioprotective effects. This documentation is mainly from in vitro studies, but also animal studies are arising. Evidence from human studies evaluating the positive health effects of marine proteins and peptides are scarce. In one study, a reduction in oxidative stress after intake of cod has been documented and a few human clinical trials have been performed evaluating the effect on blood pressure. The results are, however, inconclusive. The majority of the human clinical trials performed to investigate positive health effects of marine protein and lean fish intake, has focused on blood lipids. While some studies have documented a reduction in triglycerides after intake of lean fish, others have documented no effects. View Full-Text
Keywords: marine; proteins; peptides; bioactive; antioxidative; clinical trials; preclinical; animal studies marine; proteins; peptides; bioactive; antioxidative; clinical trials; preclinical; animal studies
MDPI and ACS Style

Jensen, I.-J.; Mæhre, H.K. Preclinical and Clinical Studies on Antioxidative, Antihypertensive and Cardioprotective Effect of Marine Proteins and Peptides—A Review. Mar. Drugs 2016, 14, 211.

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