Next Article in Journal
New Drugs from Marine Organisms in Alzheimer’s Disease
Previous Article in Journal
In Vitro and in Vivo Anticancer Activity of Pardaxin against Proliferation and Growth of Oral Squamous Cell Carcinoma
Previous Article in Special Issue
MytiLec, a Mussel R-Type Lectin, Interacts with Surface Glycan Gb3 on Burkitt’s Lymphoma Cells to Trigger Apoptosis through Multiple Pathways
Article Menu

Export Article

Open AccessArticle
Mar. Drugs 2016, 14(1), 3;

The Structure-Activity Relationship between Marine Algae Polysaccharides and Anti-Complement Activity

Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China
College of Earth Science, University of Chinese Academy of Sciences, Beijing 100049, China
Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266071, China
The School of Materials Sciences and Chemical Engineering, Ningbo University, Ningbo 315211, China
Author to whom correspondence should be addressed.
Academic Editor: Gerald Murphy
Received: 30 July 2015 / Revised: 2 December 2015 / Accepted: 13 December 2015 / Published: 25 December 2015
(This article belongs to the Special Issue Marine Glycoconjugates)
Full-Text   |   PDF [2386 KB, uploaded 25 December 2015]   |  


In this study, 33 different polysaccharides were prepared to investigate the structure-activity relationships between the polysaccharides, mainly from marine algae, and anti-complement activity in the classical pathway. Factors considered included extraction methods, fractionations, molecular weight, molar ratio of galactose to fucose, sulfate, uronic acid (UA) content, linkage, branching, and the type of monosaccharide. It was shown that the larger the molecular weights, the better the activities. The molar ratio of galactose (Gal) to fucose (Fuc) was a positive factor at a concentration lower than 10 µg/mL, while it had no effect at a concentration more than 10 µg/mL. In addition, sulfate was necessary; however, the sulfate content, the sulfate pattern, linkage and branching had no effect at a concentration of more than 10 µg/mL. Moreover, the type of monosaccharide had no effect. Laminaran and UA fractions had no activity; however, they could reduce the activity by decreasing the effective concentration of the active composition when they were mixed with the active compositions. The effect of the extraction methods could not be determined. Finally, it was observed that sulfated galactofucan showed good anti-complement activity after separation. View Full-Text
Keywords: marine algae polysaccharides; anti-complement activity; structure-activity relationship marine algae polysaccharides; anti-complement activity; structure-activity relationship

Figure 1a

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Jin, W.; Zhang, W.; Liang, H.; Zhang, Q. The Structure-Activity Relationship between Marine Algae Polysaccharides and Anti-Complement Activity. Mar. Drugs 2016, 14, 3.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top