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Mar. Drugs 2016, 14(1), 18;

Five New Cytotoxic Metabolites from the Marine Fungus Neosartorya pseudofischeri

School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China
Guangdong Technology Research Center for Advanced Chinese Medicine, Guangzhou 510006, China
Lab of Insect Toxicology, South China Agricultural University, Guangzhou 510642, China
School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China
Author to whom correspondence should be addressed.
Academic Editor: Orazio Taglialatela-Scafati
Received: 27 October 2015 / Revised: 21 December 2015 / Accepted: 30 December 2015 / Published: 13 January 2016
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The marine fungus Neosartorya pseudofischeri was isolated from Acanthaster planci from the South China Sea. In a preliminary bioactivity screening, the crude methanol extract of the fungal mycelia showed significant inhibitory activity against the Sf9 cell line from the fall armyworm Spodoptera frugiperda. Five novel compounds, including 5-olefin phenylpyropene A (1), 13-dehydroxylpyripyropene A (4), deacetylsesquiterpene (7), 5-formyl-6-hydroxy-8-isopropyl-2- naphthoic acid (9) and 6,8-dihydroxy-3-((1E,3E)-penta-1,3-dien-1-yl)isochroman-1-one (10), together with eleven known compounds, phenylpyropene A (2) and C (3), pyripyropene A (5), 7-deacetylpyripyropene A (6), (1S,2R,4aR,5R,8R,8aR)-1,8a-dihydroxy-2-acetoxy-3,8-dimethyl-5- (prop-1-en-2-yl)-1,2,4a, 5,6,7,8,8a-octahydronaphthalene (8), isochaetominine C (11), trichodermamide A (12), indolyl-3-acetic acid methyl ester (13), 1-acetyl-β-carboline (14), 1,2,3,4-tetrahydro-6-hydroxyl-2-methyl-l,3,4-trioxopyrazino[l,2-a]-indole (15) and fumiquinazoline F (16), were obtained. The structures of these compounds were determined mainly by MS and NMR data. The absolute configuration of 9 was assigned by the single-crystal X-ray diffraction studies. Compounds 111 and 15 showed significant cytotoxicity against the Sf9 cells from S. frugiperda. View Full-Text
Keywords: marine fungus; Neosartorya pseudofischeri; phenylpyropene; pyripyropene; sesquiterpene; cytotoxic activity marine fungus; Neosartorya pseudofischeri; phenylpyropene; pyripyropene; sesquiterpene; cytotoxic activity

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Lan, W.-J.; Fu, S.-J.; Xu, M.-Y.; Liang, W.-L.; Lam, C.-K.; Zhong, G.-H.; Xu, J.; Yang, D.-P.; Li, H.-J. Five New Cytotoxic Metabolites from the Marine Fungus Neosartorya pseudofischeri. Mar. Drugs 2016, 14, 18.

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