Bioactive Polycyclic Quinones from Marine Streptomyces sp. 182SMLY
AbstractChemical investigation of the cultures of marine Streptomyces sp. 182SMLY led to the discovery of two new polycyclic anthraquinones, which were elucidated as N-acetyl-N-demethylmayamycin (1) and streptoanthraquinone A (2) based on the extensive spectroscopic analysis including 2D NMR, HRESIMS, and an electronic circular dichroism (ECD) calculation. Both anthraquinones remarkably suppressed the proliferation of four different glioma cell lines with IC50 values in a range from 0.5 to 7.3 μM and induced apoptosis in the glioma cells. The ratios of IC50 for normal human astrocytes to IC50 for glioma cells were 6.4–53 for 1 and >14–31 for 2. N-acetyl-N-demethylmayamycin (1) also inhibited the growth of methicillin-resistant Staphylococcus aureus with MIC 20.0 μM. View Full-Text
- Supplementary File 1:
Supplementary (PDF, 2899 KB)
Share & Cite This Article
Liang, Y.; Xie, X.; Chen, L.; Yan, S.; Ye, X.; Anjum, K.; Huang, H.; Lian, X.; Zhang, Z. Bioactive Polycyclic Quinones from Marine Streptomyces sp. 182SMLY. Mar. Drugs 2016, 14, 10.
Liang Y, Xie X, Chen L, Yan S, Ye X, Anjum K, Huang H, Lian X, Zhang Z. Bioactive Polycyclic Quinones from Marine Streptomyces sp. 182SMLY. Marine Drugs. 2016; 14(1):10.Chicago/Turabian Style
Liang, Ying; Xie, Xin; Chen, Lu; Yan, Shilun; Ye, Xuewei; Anjum, Komal; Huang, Haocai; Lian, Xiaoyuan; Zhang, Zhizhen. 2016. "Bioactive Polycyclic Quinones from Marine Streptomyces sp. 182SMLY." Mar. Drugs 14, no. 1: 10.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.