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Mar. Drugs 2015, 13(7), 4344-4356;

New α-Glucosidase Inhibitory Triterpenic Acid from Marine Macro Green Alga Codium dwarkense Boergs

UoN Chair of Oman's Medicinal Plants and Marine Natural Products, University of Nizwa, Birkat Al-Mouz, Nizwa-616, Oman
Marine Science and Fisheries Center, Ministry of Agriculture and Fisheries Resources, Muscat-113, Oman
Department of Biological Sciences and Chemistry, University of Nizwa, Birkat Al-Mauz, Nizwa-616, Oman
Authors to whom correspondence should be addressed.
Academic Editor: Valeria Costantino
Received: 6 June 2015 / Revised: 29 June 2015 / Accepted: 6 July 2015 / Published: 14 July 2015
(This article belongs to the Special Issue Marine Secondary Metabolites)
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The marine ecosystem has been a key resource for secondary metabolites with promising biological roles. In the current study, bioassay-guided phytochemical investigations were carried out to assess the presence of enzyme inhibitory chemical constituents from the methanolic extract of marine green alga—Codium dwarkense. The bioactive fractions were further subjected to chromatographic separations, which resulted in the isolation of a new triterpenic acid; dwarkenoic acid (1) and the known sterols; androst-5-en-3β-ol (2), stigmasta-5,25-dien-3β,7α-diol (3), ergosta-5,25-dien-3β-ol (4), 7-hydroxystigmasta-4,25-dien-3-one-7-O-β-d-fucopyranoside (5), 7-hydroxystigmasta-4,25-dien-3-one (6), and stigmasta-5,25-dien-3β-ol (7). The structure elucidation of the new compound was carried out by combined mass spectrometry and 1D (1H and 13C) and 2D (HSQC, HMBC, COSY, and NOESY) NMR spectroscopic data. The sub-fractions and pure constituents were assayed for enzymatic inhibition of alpha-glucosidase. Compound 1 showed significant inhibition at all concentrations. Compounds 2, 3, 5, and 7 exhibited a dose-dependent response, whereas compounds 46 showed moderate inhibition. Utilizing such marine-derived biological resources could lead to drug discoveries related to anti-diabetics. View Full-Text
Keywords: Codium dwarkense; isolation; characterization; enzyme inhibition Codium dwarkense; isolation; characterization; enzyme inhibition

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Ali, L.; Khan, A.L.; Al-Kharusi, L.; Hussain, J.; Al-Harrasi, A. New α-Glucosidase Inhibitory Triterpenic Acid from Marine Macro Green Alga Codium dwarkense Boergs. Mar. Drugs 2015, 13, 4344-4356.

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