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Red Algae (Rhodophyta) from the Coast of Madagascar: Preliminary Bioactivity Studies and Isolation of Natural Products

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Department Chemie, Technische Universität Dresden, Bergstr. 66, 01069 Dresden, Germany
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Centre National de Recherche sur l'Environnement, MESupRes, BP 1739, Antananarivo 101, Madagascar
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Laboratoire de Chimie Appliquée aux Substances Naturelles, Faculté des Sciences, Université d'Antananarivo, BP 566, Antananarivo 101, Madagascar
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Author to whom correspondence should be addressed.
Academic Editor: Anake Kijjoa
Mar. Drugs 2015, 13(7), 4197-4216; https://doi.org/10.3390/md13074197
Received: 25 March 2015 / Revised: 18 June 2015 / Accepted: 25 June 2015 / Published: 7 July 2015
Several species of red algae (Rhodophyta) from the coastal regions of Madagascar have been investigated for their natural products. The most abundant compound was cholesterol (5) in combination with a series of oxidized congeners. The brominated indoles 13 along with the sesquiterpene debilone (4) have been isolated from Laurencia complanata. For the first time, debilone (4) has been obtained from a marine plant. From the methanol extract of Calloseris sp., we have achieved the second isolation of the unusual A-ring contracted steroids (−)-2-ethoxycarbonyl-2β-hydroxy-A-nor-cholest-5-en-4-one (9) and phorbasterone B (10). The crude extracts of Laurencia complanata exhibited antimicrobial activity against Bacillus cereus, Staphylococcus aureus, Streptococcus pneumoniae, and Candida albicans. View Full-Text
Keywords: algae; indole alkaloids; steroids; NMR spectroscopy; antimicrobial activity algae; indole alkaloids; steroids; NMR spectroscopy; antimicrobial activity
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Rahelivao, M.P.; Gruner, M.; Andriamanantoanina, H.; Andriamihaja, B.; Bauer, I.; Knölker, H.-J. Red Algae (Rhodophyta) from the Coast of Madagascar: Preliminary Bioactivity Studies and Isolation of Natural Products. Mar. Drugs 2015, 13, 4197-4216.

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