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Mar. Drugs 2015, 13(7), 4179-4196;

Functional and Structural Characterization of FAU Gene/Protein from Marine Sponge Suberites domuncula

Division of Molecular Biology, Ruđer Bošković Institute, Zagreb 10000, Croatia
Forensic Science Centre "Ivan Vučetić", Zagreb 10000, Croatia
Division of Molecular Medicine, Ruđer Bošković Institute, Zagreb 10000, Croatia
The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramaty-Gan 5290002, Israel
Queen's University Belfast, Marine Laboratory, Portaferry BT22 1PF, Northern Ireland, UK
Department of Biology, Faculty of Science, University of Zagreb, Zagreb 10000, Croatia
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Academic Editors: Friedemann Honecker and Sergey A. Dyshlovoy
Received: 6 May 2015 / Revised: 3 June 2015 / Accepted: 8 June 2015 / Published: 7 July 2015
(This article belongs to the Collection Marine Compounds and Cancer)
Full-Text   |   PDF [1169 KB, uploaded 7 July 2015]   |  


Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (FAU) gene is down-regulated in human prostate, breast and ovarian cancers. Moreover, its dysregulation is associated with poor prognosis in breast cancer. Sponges (Porifera) are animals without tissues which branched off first from the common ancestor of all metazoans. A large majority of genes implicated in human cancers have their homologues in the sponge genome. Our study suggests that FAU gene from the sponge Suberites domuncula reflects characteristics of the FAU gene from the metazoan ancestor, which have changed only slightly during the course of animal evolution. We found pro-apoptotic activity of sponge FAU protein. The same as its human homologue, sponge FAU increases apoptosis in human HEK293T cells. This indicates that the biological functions of FAU, usually associated with “higher” metazoans, particularly in cancer etiology, possess a biochemical background established early in metazoan evolution. The ancestor of all animals possibly possessed FAU protein with the structure and function similar to evolutionarily more recent versions of the protein, even before the appearance of true tissues and the origin of tumors and metastasis. It provides an opportunity to use pre-bilaterian animals as a simpler model for studying complex interactions in human cancerogenesis. View Full-Text
Keywords: ribosomal protein genes; snoRNA; FAU; RPS30; SNORA62; evolution; Porifera ribosomal protein genes; snoRNA; FAU; RPS30; SNORA62; evolution; Porifera

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Perina, D.; Korolija, M.; Hadžija, M.P.; Grbeša, I.; Belužić, R.; Imešek, M.; Morrow, C.; Marjanović, M.P.; Bakran-Petricioli, T.; Mikoč, A.; Ćetković, H. Functional and Structural Characterization of FAU Gene/Protein from Marine Sponge Suberites domuncula. Mar. Drugs 2015, 13, 4179-4196.

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