Next Article in Journal
Red Algae (Rhodophyta) from the Coast of Madagascar: Preliminary Bioactivity Studies and Isolation of Natural Products
Next Article in Special Issue
Marine Compounds and Cancer: Where Do We Stand?
Previous Article in Journal
Bioactive 7-Oxabicyclic[6.3.0]lactam and 12-Membered Macrolides from a Gorgonian-Derived Cladosporium sp. Fungus
Previous Article in Special Issue
Xyloketal B Suppresses Glioblastoma Cell Proliferation and Migration in Vitro through Inhibiting TRPM7-Regulated PI3K/Akt and MEK/ERK Signaling Pathways
Open AccessArticle

Functional and Structural Characterization of FAU Gene/Protein from Marine Sponge Suberites domuncula

1
Division of Molecular Biology, Ruđer Bošković Institute, Zagreb 10000, Croatia
2
Forensic Science Centre "Ivan Vučetić", Zagreb 10000, Croatia
3
Division of Molecular Medicine, Ruđer Bošković Institute, Zagreb 10000, Croatia
4
The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramaty-Gan 5290002, Israel
5
Queen's University Belfast, Marine Laboratory, Portaferry BT22 1PF, Northern Ireland, UK
6
Department of Biology, Faculty of Science, University of Zagreb, Zagreb 10000, Croatia
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Friedemann Honecker and Sergey A. Dyshlovoy
Mar. Drugs 2015, 13(7), 4179-4196; https://doi.org/10.3390/md13074179
Received: 6 May 2015 / Revised: 3 June 2015 / Accepted: 8 June 2015 / Published: 7 July 2015
(This article belongs to the Collection Marine Compounds and Cancer)
Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (FAU) gene is down-regulated in human prostate, breast and ovarian cancers. Moreover, its dysregulation is associated with poor prognosis in breast cancer. Sponges (Porifera) are animals without tissues which branched off first from the common ancestor of all metazoans. A large majority of genes implicated in human cancers have their homologues in the sponge genome. Our study suggests that FAU gene from the sponge Suberites domuncula reflects characteristics of the FAU gene from the metazoan ancestor, which have changed only slightly during the course of animal evolution. We found pro-apoptotic activity of sponge FAU protein. The same as its human homologue, sponge FAU increases apoptosis in human HEK293T cells. This indicates that the biological functions of FAU, usually associated with “higher” metazoans, particularly in cancer etiology, possess a biochemical background established early in metazoan evolution. The ancestor of all animals possibly possessed FAU protein with the structure and function similar to evolutionarily more recent versions of the protein, even before the appearance of true tissues and the origin of tumors and metastasis. It provides an opportunity to use pre-bilaterian animals as a simpler model for studying complex interactions in human cancerogenesis. View Full-Text
Keywords: ribosomal protein genes; snoRNA; FAU; RPS30; SNORA62; evolution; Porifera ribosomal protein genes; snoRNA; FAU; RPS30; SNORA62; evolution; Porifera
Show Figures

Figure 1

MDPI and ACS Style

Perina, D.; Korolija, M.; Hadžija, M.P.; Grbeša, I.; Belužić, R.; Imešek, M.; Morrow, C.; Marjanović, M.P.; Bakran-Petricioli, T.; Mikoč, A.; Ćetković, H. Functional and Structural Characterization of FAU Gene/Protein from Marine Sponge Suberites domuncula. Mar. Drugs 2015, 13, 4179-4196. https://doi.org/10.3390/md13074179

AMA Style

Perina D, Korolija M, Hadžija MP, Grbeša I, Belužić R, Imešek M, Morrow C, Marjanović MP, Bakran-Petricioli T, Mikoč A, Ćetković H. Functional and Structural Characterization of FAU Gene/Protein from Marine Sponge Suberites domuncula. Marine Drugs. 2015; 13(7):4179-4196. https://doi.org/10.3390/md13074179

Chicago/Turabian Style

Perina, Dragutin; Korolija, Marina; Hadžija, Marijana P.; Grbeša, Ivana; Belužić, Robert; Imešek, Mirna; Morrow, Christine; Marjanović, Melanija P.; Bakran-Petricioli, Tatjana; Mikoč, Andreja; Ćetković, Helena. 2015. "Functional and Structural Characterization of FAU Gene/Protein from Marine Sponge Suberites domuncula" Mar. Drugs 13, no. 7: 4179-4196. https://doi.org/10.3390/md13074179

Find Other Styles

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Search more from Scilit
 
Search
Back to TopTop