Next Article in Journal
Characterization of Shrimp Oil from Pandalus borealis by High Performance Liquid Chromatography and High Resolution Mass Spectrometry
Previous Article in Journal
Dangerous Relations in the Arctic Marine Food Web: Interactions between Toxin Producing Pseudo-nitzschia Diatoms and Calanus Copepodites
Open AccessArticle

Amino Acid-Derived Metabolites from the Ascidian Aplidium sp.

1
Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea
2
Department of Agricultural Biotechnology, College of Agriculture and Life Science, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-921, Korea
3
Department of Biological Science, College of Life Science, Ewha Womans University, 52, Ewhayeodae-gil, Seodaemun, Seoul 120-750, Korea
*
Authors to whom correspondence should be addressed.
Academic Editor: Orazio Taglialatela-Scafati
Mar. Drugs 2015, 13(6), 3836-3848; https://doi.org/10.3390/md13063836
Received: 21 April 2015 / Accepted: 5 June 2015 / Published: 16 June 2015
Four new iodobenzene-containing dipeptides (14), a related bromotryptophan-containing dipeptide (5), and an iodophenethylamine (6) were isolated from the ascidian Aplidium sp. collected off the coast of Chuja-do, Korea. The structures of these novel compounds, designated as apliamides A–E (15) and apliamine A (6) were determined via combined spectroscopic analyses. The absolute configuration of the amino acid residue in 1 was determined by advanced Marfey’s analysis. Several of these compounds exhibited moderate cytotoxicity and significant inhibition against Na+/K+-ATPase (4). View Full-Text
Keywords: dipeptides; apliamides; Aplidium sp.; Marfey’s analysis; bioactivities dipeptides; apliamides; Aplidium sp.; Marfey’s analysis; bioactivities
Show Figures

Figure 1

MDPI and ACS Style

Won, T.H.; Kim, C.-K.; Lee, S.-H.; Rho, B.J.; Lee, S.K.; Oh, D.-C.; Oh, K.-B.; Shin, J. Amino Acid-Derived Metabolites from the Ascidian Aplidium sp.. Mar. Drugs 2015, 13, 3836-3848.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Search more from Scilit
 
Search
Back to TopTop