Next Article in Journal
Anti-Restenotic Roles of Dihydroaustrasulfone Alcohol Involved in Inhibiting PDGF-BB-Stimulated Proliferation and Migration of Vascular Smooth Muscle Cells
Next Article in Special Issue
Enhanced Control of Bladder-Associated Tumors Using Shrimp Anti-Lipopolysaccharide Factor (SALF) Antimicrobial Peptide as a Cancer Vaccine Adjuvant in Mice
Previous Article in Journal
Marine Polysaccharides from Algae with Potential Biomedical Applications
Previous Article in Special Issue
Emerging Concepts Promising New Horizons for Marine Biodiscovery and Synthetic Biology
Open AccessArticle

Antitumor and Antimicrobial Activity of Some Cyclic Tetrapeptides and Tripeptides Derived from Marine Bacteria

1
Department of Chemistry, National Dong Hwa University, Hualien 974, Taiwan
2
Department of Life Science, National Dong Hwa University, Hualien 974, Taiwan
*
Author to whom correspondence should be addressed.
Academic Editor: Peter Duggan
Mar. Drugs 2015, 13(5), 3029-3045; https://doi.org/10.3390/md13053029
Received: 21 April 2015 / Revised: 22 April 2015 / Accepted: 6 May 2015 / Published: 15 May 2015
(This article belongs to the Special Issue Marine Peptides and Their Mimetics)
Marine derived cyclo(Gly-l-Ser-l-Pro-l-Glu) was selected as a lead to evaluate antitumor-antibiotic activity. Histidine was chosen to replace the serine residue to form cyclo(Gly-l-His-l-Pro-l-Glu). Cyclic tetrapeptides (CtetPs) were then synthesized using a solution phase method, and subjected to antitumor and antibiotic assays. The benzyl group protected CtetPs derivatives, showed better activity against antibiotic-resistant Staphylococcus aureus in the range of 60–120 μM. Benzyl group protected CtetPs 3 and 4, exhibited antitumor activity against several cell lines at a concentration of 80–108 μM. However, shortening the size of the ring to the cyclic tripeptide (CtriP) scaffold, cyclo(Gly-l-Ser-l-Pro), cyclo(Ser-l-Pro-l-Glu) and their analogues showed no antibiotic or antitumor activity. This phenomenon can be explained from their backbone structures. View Full-Text
Keywords: antibiotic; antitumor; cyclic tetrapeptide; cyclic tripeptide antibiotic; antitumor; cyclic tetrapeptide; cyclic tripeptide
Show Figures

Figure 1

MDPI and ACS Style

Chakraborty, S.; Tai, D.-F.; Lin, Y.-C.; Chiou, T.-W. Antitumor and Antimicrobial Activity of Some Cyclic Tetrapeptides and Tripeptides Derived from Marine Bacteria. Mar. Drugs 2015, 13, 3029-3045.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop