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Open AccessReview

Recent Advances in Exopolysaccharides from Paenibacillus spp.: Production, Isolation, Structure, and Bioactivities

Department of Chemistry/Life Science Development Centre, Tamkang University, New Taipei City 25137, Taiwan
Author to whom correspondence should be addressed.
No. 151, Yingchuan Rd., Tamsui, New Taipei City 25137, Taiwan.
Academic Editor: Paola Laurienzo
Mar. Drugs 2015, 13(4), 1847-1863;
Received: 24 February 2015 / Revised: 23 March 2015 / Accepted: 25 March 2015 / Published: 1 April 2015
(This article belongs to the Collection Marine Polysaccharides)
PDF [425 KB, uploaded 1 April 2015]


This review provides a comprehensive summary of the most recent developments of various aspects (i.e., production, purification, structure, and bioactivity) of the exopolysaccharides (EPSs) from Paenibacillus spp. For the production, in particular, squid pen waste was first utilized successfully to produce a high yield of inexpensive EPSs from Paenibacillus sp. TKU023 and P. macerans TKU029. In addition, this technology for EPS production is prevailing because it is more environmentally friendly. The Paenibacillus spp. EPSs reported from various references constitute a structurally diverse class of biological macromolecules with different applications in the broad fields of pharmacy, cosmetics and bioremediation. The EPS produced by P. macerans TKU029 can increase in vivo skin hydration and may be a new source of natural moisturizers with potential value in cosmetics. However, the relationships between the structures and activities of these EPSs in many studies are not well established. The contents and data in this review will serve as useful references for further investigation, production, structure and application of Paenibacillus spp. EPSs in various fields. View Full-Text
Keywords: Paenibacillus spp.; exopolysaccharides; squid pen; production; purification; bioactivity Paenibacillus spp.; exopolysaccharides; squid pen; production; purification; bioactivity

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Liang, T.-W.; Wang, S.-L. Recent Advances in Exopolysaccharides from Paenibacillus spp.: Production, Isolation, Structure, and Bioactivities. Mar. Drugs 2015, 13, 1847-1863.

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