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Co-Processed Chitin-Mannitol as a New Excipient for Oro-Dispersible Tablets

The Jordanian Pharmaceutical Manufacturing Co., PO Box 94, Naor 11710, Jordan
Faculty of Engineering & Science, University of Greenwich, Medway Campus, Chatham Maritime Kent ME44TB, UK
Author to whom correspondence should be addressed.
Academic Editor: David Harding
Mar. Drugs 2015, 13(4), 1739-1764;
Received: 2 November 2014 / Revised: 21 January 2015 / Accepted: 9 February 2015 / Published: 30 March 2015
(This article belongs to the Special Issue Advances in Marine Chitin and Chitosan)
PDF [1257 KB, uploaded 31 March 2015]


This study describes the preparation, characterization and performance of a novel excipient for use in oro-dispersible tablets (ODT). The excipient (CopCM) consists of chitin and mannitol. The excipient with optimal physicochemical properties was obtained at a chitin: mannitol ratio of 2:8 (w/w) and produced by roll compaction (RC). Differential scanning calorimetry (DSC), Fourier transform-Infrared (FT-IR), X-ray powder diffraction (XRPD) and scanning electron microscope (SEM) techniques were used to characterize CopCM, in addition to characterization of its powder and ODT dosage form. The effect of particle size distribution of CopCM was investigated and found to have no significant influence on the overall tablet physical properties. The compressibility parameter (a) for CopCM was calculated from a Kawakita plot and found to be higher (0.661) than that of mannitol (0.576) due to the presence of the highly compressible chitin (0.818). Montelukast sodium and domperidone ODTs produced, using CopCM, displayed excellent physicochemical properties. The exceptional binding, fast wetting and superdisintegration properties of CopCM, in comparison with commercially available co-processed ODT excipients, results in a unique multifunctional base which can successfully be used in the formulation of oro-dispersible and fast immediate release tablets. View Full-Text
Keywords: crystalline mannitol; α-chitin; roll compaction; oro-dispersible tablets crystalline mannitol; α-chitin; roll compaction; oro-dispersible tablets

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Daraghmeh, N.; Chowdhry, B.Z.; Leharne, S.A.; Al Omari, M.M.H.; Badwan, A.A. Co-Processed Chitin-Mannitol as a New Excipient for Oro-Dispersible Tablets. Mar. Drugs 2015, 13, 1739-1764.

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