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Sargassopenillines A–G, 6,6-Spiroketals from the Alga-Derived Fungi Penicillium thomii and Penicillium lividum

1
Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Sciences, Prospect 100-let Vladivostoku 159, Vladivostok 690022, Russia
2
Far Eastern Federal University, Suhanova 8, Vladivostok 690950, Russia
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Mar. Drugs 2014, 12(12), 5930-5943; https://doi.org/10.3390/md12125930
Received: 24 September 2014 / Revised: 21 November 2014 / Accepted: 2 December 2014 / Published: 9 December 2014
Seven new 6,6-spiroketals, sargassopenillines A–G (17) were isolated from the alga-derived fungi Penicillium thomii KMM 4645 and Penicillium lividum KMM 4663. The structures of these metabolites were determined by HR-MS and 1D and 2D NMR. The absolute configurations of compounds 1, 5 and 6 were assigned by the modified Mosher’s method and by CD data. Sargassopenilline C (3) inhibited the transcriptional activity of the oncogenic nuclear factor AP-1 with an IC50 value of 15 µM. View Full-Text
Keywords: marine fungi; Penicillium thomii; Penicillium lividum; 6,6-spiroketals marine fungi; Penicillium thomii; Penicillium lividum; 6,6-spiroketals
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Zhuravleva, O.I.; Sobolevskaya, M.P.; Afiyatullov, S.S.; Kirichuk, N.N.; Denisenko, V.A.; Dmitrenok, P.S.; Yurchenko, E.A.; Dyshlovoy, S.A. Sargassopenillines A–G, 6,6-Spiroketals from the Alga-Derived Fungi Penicillium thomii and Penicillium lividum. Mar. Drugs 2014, 12, 5930-5943.

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Mar. Drugs, EISSN 1660-3397, Published by MDPI AG
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