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Dinophysis Toxins: Causative Organisms, Distribution and Fate in Shellfish

Spanish Institute of Oceanography (IEO), Oceanographic Centre of Vigo, Subida a Radio Faro 50, Vigo 36390, Spain
Marine Research Institute (IIM-CSIC), Eduardo Cabello 6, Vigo 36080, Spain
Fisheries Research Programme & Aquaculture Institute, Austral University of Chile, Los Pinos s/n, Balneario Pelluco, Puerto Montt 5480000, Chile
Fisheries Institute (IFOP), Enrique Abello 0552, Punta Arenas 6200000, Chile
Marine Research Centre (CIMA), Pedras do Corón s/n, Aptdo. 13, Vilanova de Arousa, Pontevedra 36620, Spain
Authors to whom correspondence should be addressed.
Mar. Drugs 2014, 12(1), 394-461;
Received: 11 November 2013 / Revised: 29 November 2013 / Accepted: 31 December 2013 / Published: 20 January 2014
(This article belongs to the Special Issue Marine Shellfish Toxins)
Several Dinophysis species produce diarrhoetic toxins (okadaic acid and dinophysistoxins) and pectenotoxins, and cause gastointestinal illness, Diarrhetic Shellfish Poisoning (DSP), even at low cell densities (<103 cells·L−1). They are the main threat, in terms of days of harvesting bans, to aquaculture in Northern Japan, Chile, and Europe. Toxicity and toxin profiles are very variable, more between strains than species. The distribution of DSP events mirrors that of shellfish production areas that have implemented toxin regulations, otherwise misinterpreted as bacterial or viral contamination. Field observations and laboratory experiments have shown that most of the toxins produced by Dinophysis are released into the medium, raising questions about the ecological role of extracelular toxins and their potential uptake by shellfish. Shellfish contamination results from a complex balance between food selection, adsorption, species-specific enzymatic transformations, and allometric processes. Highest risk areas are those combining Dinophysis strains with high cell content of okadaates, aquaculture with predominance of mytilids (good accumulators of toxins), and consumers who frequently include mussels in their diet. Regions including pectenotoxins in their regulated phycotoxins will suffer from much longer harvesting bans and from disloyal competition with production areas where these toxins have been deregulated. View Full-Text
Keywords: Dinophysis; diarrhoetic shellfish toxins; pectenotoxins; diarrhoetic shellfish poisoning; DSP; harmful algal blooms; DSP distribution and impacts Dinophysis; diarrhoetic shellfish toxins; pectenotoxins; diarrhoetic shellfish poisoning; DSP; harmful algal blooms; DSP distribution and impacts
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Reguera, B.; Riobó, P.; Rodríguez, F.; Díaz, P.A.; Pizarro, G.; Paz, B.; Franco, J.M.; Blanco, J. Dinophysis Toxins: Causative Organisms, Distribution and Fate in Shellfish. Mar. Drugs 2014, 12, 394-461.

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