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Open AccessArticle

Discovery of Novel Diterpenoids from Sinularia arborea

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Graduate Institute of Marine Biotechnology, Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan
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National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
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Institute of Oceanography, National Taiwan University, Taipei 106, Taiwan
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Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan
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Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan
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Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan 333, Taiwan
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Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 907, Taiwan
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School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan
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Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan
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Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan
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Department of Marine Biotechnology and Resources and Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
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Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung 804, Taiwan
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Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
*
Author to whom correspondence should be addressed.
Mar. Drugs 2014, 12(1), 385-393; https://doi.org/10.3390/md12010385
Received: 5 November 2013 / Revised: 23 November 2013 / Accepted: 3 January 2014 / Published: 17 January 2014
Two novel diterpenoids, sinularbols A (1) and B (2), which were found to possess a new carbon skeleton were isolated from the soft coral Sinularia arborea. The structures of compounds 1 and 2 were elucidated by spectroscopic methods and 2 displayed a moderately inhibitory effect on the generation of superoxide anion by human neutrophils. View Full-Text
Keywords: sinularbol; sinularborane; diterpenoid; Sinularia arborea; superoxide anion sinularbol; sinularborane; diterpenoid; Sinularia arborea; superoxide anion
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Chen, K.-H.; Dai, C.-F.; Hwang, T.-L.; Chen, C.-Y.; Li, J.-J.; Chen, J.-J.; Wu, Y.-C.; Sheu, J.-H.; Wang, W.-H.; Sung, P.-J. Discovery of Novel Diterpenoids from Sinularia arborea. Mar. Drugs 2014, 12, 385-393.

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