Next Article in Journal
Ovatoxin-a and Palytoxin Accumulation in Seafood in Relation to Ostreopsis cf. ovata Blooms on the French Mediterranean Coast
Previous Article in Journal
Novel Marine Phenazines as Potential Cancer Chemopreventive and Anti-Inflammatory Agents
Open AccessArticle

Anti-Melanogenic Property of Geoditin A in Murine B16 Melanoma Cells

1
School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
2
Department of Medical Chemistry & Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 S. Wood Street, Chicago, IL 60612, USA
*
Author to whom correspondence should be addressed.
Mar. Drugs 2012, 10(2), 465-476; https://doi.org/10.3390/md10020465
Received: 23 November 2011 / Revised: 29 December 2011 / Accepted: 3 February 2012 / Published: 16 February 2012
Geoditin A, an isomalabaricane triterpene isolated from marine sponge Geodia japonica, has been demonstrated to induce apoptosis in leukemia HL60 cells and human colon HT29 cancer cells through an oxidative stress, a process also interfering with normal melanogenesis in pigment cells. Treatment of murine melanoma B16 cells with geoditin A decreased expression of melanogenic proteins and cell melanogenesis which was aggravated with adenylate cyclase inhibitor SQ22536, indicating melanogenic inhibition was mediated through a cAMP-dependent signaling pathway. Immunofluorescence microscopy and glycosylation studies revealed abnormal glycosylation patterns of melanogenic proteins (tyrosinase and tyrosinase-related protein 1), and a co-localization of tyrosinase with calnexin (CNX) and lysosome-associated membrane protein 1 (LAMP-1), implicating a post-translational modification in the ER and a degradation of tyrosinase in the lysosome. Taken together, potent anti-melanogenic property and the relatively low cytotoxicity of geoditin A have demonstrated its therapeutic potential as a skin lightening agent. View Full-Text
Keywords: geoditin A; B16 melanoma cells; melanogenesis; tyrosinase geoditin A; B16 melanoma cells; melanogenesis; tyrosinase
Show Figures

Figure 1

MDPI and ACS Style

Cheung, F.W.K.; Guo, J.; Ling, Y.-H.; Che, C.-T.; Liu, W.-K. Anti-Melanogenic Property of Geoditin A in Murine B16 Melanoma Cells. Mar. Drugs 2012, 10, 465-476.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Search more from Scilit
 
Search
Back to TopTop