Occurrence and Impact of Intraoperative Anastomotic Leakage in Retzius-Sparing Robot-Assisted Radical Prostatectomy
Abstract
1. Introduction
2. Methods
2.1. Patient Population
2.2. Surgical Technique
2.3. Postoperative Evaluation
2.4. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
- Barsouk, A.; Padala, S.A.; Vakiti, A.; Mohammed, A.; Saginala, K.; Thandra, K.C.; Rawla, P.; Barsouk, A. Epidemiology, staging and management of prostate cancer. Med. Sci. 2020, 8, 28. [Google Scholar] [CrossRef] [PubMed]
- Ko, L.-C.; Gravina, N.; Berghausen, J.; Abdo, J. Rising Trends in Prostate Cancer Among Asian Men: Global Concerns and Diagnostic Solutions. Cancers 2025, 17, 1013. [Google Scholar] [CrossRef]
- Liu, P.-C.; Lin, Y.-S.; Ou, Y.-C.; Hsu, C.-Y.; Tung, M.-C.; Chiu, Y.-M. Comprehensive analysis of prostate cancer life expectancy, loss of life expectancy, and healthcare expenditures: Taiwan national cohort study spanning 2008 to 2019. PLoS ONE 2025, 20, e0310613. [Google Scholar] [CrossRef]
- Kao, C.-W.; Chiang, C.-J.; Lin, L.-J.; Lee, W.-C.; Lee, M.-Y.; Cheng-Yi, S.; Lin, H.-L.; Lin, M.-M.; Wang, Y.-P.; Chen, M.-L.; et al. Accuracy of long-form data in the Taiwan cancer registry. J. Formos. Med. Assoc. 2021, 120, 2037–2041. [Google Scholar] [CrossRef]
- Jo, S.B.; Kim, J.W. Recent Advances in Radical Prostatectomy: A Narrative Review of Surgical Innovations and Outcomes. Cancers 2025, 17, 902. [Google Scholar] [CrossRef] [PubMed]
- Castellan, P.; Ferretti, S.; Litterio, G.; Marchioni, M.; Schips, L. Management of urinary incontinence following radical prostatectomy: Challenges and solutions. Ther. Clin. Risk Manag. 2023, 19, 43–56. [Google Scholar] [CrossRef] [PubMed]
- Tillier, C.N. From Patient Reported Outcome Measures to Individualized Prostate Cancer Care. Ph.D. Thesis, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands, 2024. [Google Scholar]
- de Abreu Fonseca, A.J. Correlation Between Pelvic Anatomy on Magnetic Resonance Imaging and Urinary Continence After Radical Prostatectomy. Ph.D. Thesis, University of Porto, Porto, Portugal, 2024. [Google Scholar]
- Razdan, S.; Parekh, S.; Razdan, S. Challenging Scenarios in Radical Prostatectomy: How to Ensure Similar Functional Outcomes, in Urinary Continence and Sexual Function After Robotic Prostatectomy, Radiation, and Novel Therapies; Springer: Cham, Switzerland, 2024; pp. 115–139. [Google Scholar]
- Ma, R.; Cen, S.; Forsyth, E.; Probst, P.; Asghar, A.; Townsend, W.; Hui, A.; Desai, A.; Tzeng, M.; Cheng, E.; et al. Technical surgical skill assessment of neurovascular bundle dissection and urinary continence recovery after robotic-assisted radical prostatectomy. JU Open Plus 2023, 1, e00039. [Google Scholar] [CrossRef]
- Modig, K.K.; Godtman, R.A.; Bjartell, A.; Carlsson, S.; Haglind, E.; Hugosson, J.; Månsson, M.; Steineck, G.; Thorsteinsdottir, T.; Tyritzis, S.; et al. Vesicourethral anastomotic stenosis after open or robot-assisted laparoscopic retropubic prostatectomy—Results from the laparoscopic prostatectomy robot open trial. Eur. Urol. Focus 2021, 7, 317–324. [Google Scholar] [CrossRef]
- Nakane, A.; Kubota, H.; Noda, Y.; Takeda, T.; Hirose, Y.; Okada, A.; Mizuno, K.; Kawai, N.; Tozawa, K.; Hayashi, Y.; et al. Improvement in early urinary continence recovery after robotic-assisted radical prostatectomy based on postoperative pelvic anatomic features: A retrospective review. BMC Urol. 2019, 19, 87. [Google Scholar] [CrossRef]
- Marzorati, C.; Monzani, D.; Mazzocco, K.; Pavan, F.; Cozzi, G.; De Cobelli, O.; Monturano, M.; Pravettoni, G. Predicting trajectories of recovery in prostate cancer patients undergone Robot-Assisted Radical Prostatectomy (RARP). PLoS ONE 2019, 14, e0214682. [Google Scholar] [CrossRef]
- Kumar, A.; Patel, V.R.; Panaiyadiyan, S.; Bhat, K.R.S.; Moschovas, M.C.; Nayak, B. Nerve-sparing robot-assisted radical prostatectomy: Current perspectives. Asian J. Urol. 2021, 8, 2–13. [Google Scholar] [CrossRef]
- Arroyo, C.; Martini, A.; Wang, J.; Tewari, A.K. Anatomical, surgical and technical factors influencing continence after radical prostatectomy. Ther. Adv. Urol. 2019, 11, 1756287218813787. [Google Scholar] [CrossRef]
- Mistretta, F.A.; Galfano, A.; Di Trapani, E.; Di Trapani, D.; Russo, A.; Secco, S.; Ferro, M.; Musi, G.; Bocciardi, A.M.; de Cobelli, O. Robot assisted radical prostatectomy in kidney transplant recipients: Surgical, oncological and functional outcomes of two different robotic approaches. Int. Braz. J. Urol. 2019, 45, 262–272. [Google Scholar] [CrossRef]
- Olivero, A.; Tappero, S.; Chierigo, F.; Maltzman, O.; Secco, S.; Palagonia, E.; Piccione, A.; Bocciardi, A.M.; Galfano, A.; Dell’oglio, P.A. A comprehensive overview of intraoperative complications during retzius-sparing robot-assisted radical prostatectomy: Single series from high-volume center. Cancers 2024, 16, 1385. [Google Scholar] [CrossRef]
- Yanagisawa, T.; Kawada, T.; Mostafaei, H.; Motlagh, R.S.; Quhal, F.; Laukhtina, E.; Rajwa, P.; von Deimling, M.; Bianchi, A.; Pallauf, M.; et al. Role of pelvic drain and timing of urethral catheter removal following RARP: A systematic review and meta-analysis. BJU Int. 2023, 132, 132–145. [Google Scholar] [CrossRef]
- Ficarra, V.; Rossanese, M.; Gilante, M.; Foti, M.; Macchione, L.; Mucciardi, G.; Martini, M.; Giannarini, G. Retzius-sparing vs. standard robot-assisted radical prostatectomy for clinically localised prostate cancer: A comparative study. Prostate Cancer Prostatic Dis. 2023, 26, 568–574. [Google Scholar]
- Tai, T.-E.; Wu, C.-C.; Kang, Y.-N.; Wu, J.-C. Effects of Retzius sparing on robot-assisted laparoscopic prostatectomy: A systematic review with meta-analysis. Surg. Endosc. 2020, 34, 4020–4029. [Google Scholar] [CrossRef]
- Tillier, C.; van Muilekom, H.A.M.; der Hulst, J.B.-V.; Grivas, N.; van der Poel, H.G. Vesico-urethral anastomosis (VUA) evaluation of short-and long-term outcome after robot-assisted laparoscopic radical prostatectomy (RARP): Selective cystogram to improve outcome. J. Robot. Surg. 2017, 11, 441–446. [Google Scholar] [CrossRef]
- Barakat, B.; Othman, H.; Gauger, U.; Wolff, I.; Hadaschik, B.; Rehme, C. Retzius sparing radical prostatectomy versus robot-assisted radical prostatectomy: Which technique is more beneficial for prostate cancer patients (MASTER Study)? A systematic review and meta-analysis. Eur. Urol. Focus 2022, 8, 1060–1071. [Google Scholar] [CrossRef]
- Chierigo, F.; Caviglia, A.; Cellini, V.; Tappero, S.; Aigner, M.; Palagonia, E.; Olivero, A.; Secco, S.; Bocciardi, A.M.; Dell’oglio, P.; et al. Retzius sparing robot-assisted radical prostatectomy: Optimizing functional results. World J. Urol. 2024, 42, 385. [Google Scholar] [CrossRef]
- Kakutani, S.; Takeshima, Y.; Yamada, Y.; Fujimura, T.; Nagamoto, S.; Enomoto, Y.; Hakozaki, Y.; Kimura, N.; Teshima, T.; Akiyama, Y.; et al. Clinical significance and risk factors of urethrovesical anastomotic urinary leakage following robot-assisted radical prostatectomy: A multi-institutional study. BMC Urol. 2021, 21, 75. [Google Scholar] [CrossRef]
- Ou, H.-C.; Marian, L.; Li, C.-C.; Juan, Y.-S.; Tung, M.-C.; Shih, H.-J.; Chang, C.-P.; Chen, J.-T.; Yang, C.-H.; Ou, Y.-C. Robot-assisted radical prostatectomy by the Hugo robotic-assisted surgery (RAS) system and the da vinci system: A comparison between the two platforms. Cancers 2024, 16, 1207. [Google Scholar] [CrossRef] [PubMed]
- Tyritzis, S.I.; Katafigiotis, I.; Constantinides, C.A. All you need to know about urethrovesical anastomotic urinary leakage following radical prostatectomy. J. Urol. 2012, 188, 369–376. [Google Scholar] [CrossRef] [PubMed]
- Lai, C.-M.; Wu, R.C.; Wu, C.-H.; Wang, C.-T.; Lin, V.C. Does the Timing of Performing Robot-assisted Radical Prostatectomy after Prostate Biopsy Affect the Outcome? Urol. Sci. 2022, 33, 63–69. [Google Scholar] [CrossRef]
- Catarin, M.V.G.; Manzano, G.M.; Nóbrega, J.A.; Almeida, F.G.; Srougi, M.; Bruschini, H. The role of membranous urethral afferent autonomic innervation in the continence mechanism after nerve sparing radical prostatectomy: A clinical and prospective study. J. Urol. 2008, 180, 2527–2531. [Google Scholar] [CrossRef] [PubMed]
- John, H.; Suter, S.; Hauri, D. Effect of radical prostatectomy on urethral blood flow. Urology 2002, 59, 566–569. [Google Scholar] [CrossRef]
- Hashimoto, S.; Obinata, D.; Uchida, H.; Arakawa, S.; Inagaki, Y.; Nakahara, K.; Yoshizawa, T.; Mochida, J.; Yamaguchi, K.; Takahashi, S. Preoperative pelvic floor muscle diameter as a predictor of postoperative urinary incontinence in robotic-assisted laparoscopic total prostatectomy. BJUI Compass 2025, 6, e70001. [Google Scholar] [CrossRef]
Total (n = 230) | |||
---|---|---|---|
Characteristic | Median | (IQR) | |
Pre-op | Age (years) | 67 | (63–72) |
Height (cm) | 165.5 | (161.5–170.0) | |
Weight (kg) | 68 | (60.4–75.0) | |
BMI (kg/m2) | 24.7 | (22.8–27.0) | |
DM (n/%) | 45 | (19.6) | |
Pre-op PSA (ng/mL) | 12.2 | (7.8–25.5) | |
Prostate volume (mL) | 33 | (26.4–42.2) | |
PSA density | 0.4 | (0.2–1.0) | |
Time to operation after biopsy (days) | 56 | (48–67) | |
cT stage ≥ 3 (n/%) | 67 | (29.1) | |
High risk (n/%) | 113 | (49.1) | |
Intra-op | Console time (min) | 254 | (217–288) |
Blood loss (mL) | 150 | (100–200) | |
Without nerve-sparing (n/%) | 64 | (27.8) | |
Pelvic lymph nodes dissection (n/%) | 201 | (87.4) | |
Positive IAL (n/%) | 32 | (13.9) | |
Negative IAL (n/%) | 198 | (86.1) | |
Post-op | pT stage ≥ 3 (n/%) | 111 | (48.7) |
Pathology Gleason ≥ 8 (n/%) | 32 | (14) | |
Tumor volume (%) | 20 | (10–45) | |
PSM (n/%) | 128 | (56) | |
Hospitalization (days) | 8 | (7–9) | |
Cystography (n/%) | 32 | (13.9) | |
Overall leakage in cystography (n/%) | 2 | (0.8) |
Negative IAL (n = 198) | Positive IAL (n = 32) | p-Value | ||||
---|---|---|---|---|---|---|
Characteristic | Median | (IQR) | Median | (IQR) | ||
Pre-op | Age (years) | 67 | (63–72) | 68 | (65–74) | 0.202 |
Height (cm) | 165.8 | (161.5–170.0) | 165.3 | (161.6–169.0) | 0.841 | |
Weight (kg) | 68 | (60.3–75.0) | 67.5 | (61.5–74.5) | 0.992 | |
BMI (kg/m2) | 24.8 | (22.7–27.0) | 24.5 | (23.0–27.1) | 0.96 | |
DM (n/%) | 40 | (20.2) | 5 | (15.6) | 0.545 | |
* Pre-op PSA (ng/mL) | 11.4 | (7.0–24.8) | 20.5 | (11.9–43.1) | 0.002 | |
Prostate volume (mL) | 32.8 | (26.3–41.3) | 36.8 | (28.9–51.0) | 0.175 | |
* PSA density | 0.4 | (0.2–0.9) | 0.5 | (0.3–1.3) | 0.036 | |
Time to operation after biopsy (days) | 56 | (48–67) | 56 | (42–62) | 0.633 | |
** cT stage ≥ 3 (n/%) | 49 | (24.7) | 18 | (56.3) | <0.001 | |
* High risk (n/%) | 89 | (44.9) | 24 | (75) | 0.002 | |
Intra-op | ** Console time (min) | 249.5 | (214–282) | 277.5 | (255–322) | <0.001 |
Blood loss (mL) | 150 | (100–200) | 150 | (100–200) | 0.67 | |
* Without nerve-sparing(n/%) | 48 | (24.8) | 16 | (50) | 0.003 | |
Post-op | * pT stage ≥ 3 (n/%) | 88 | (44.9) | 23 | (71.9) | 0.004 |
Pathology Gleason ≥ 8 (n/%) | 24 | (12.1) | 8 | (25) | 0.098 | |
* Tumor volume (%) | 20 | (10–40) | 37 | (15–70) | 0.049 | |
PSM (n/%) | 106 | (54) | 22 | (69) | 0.121 | |
** Duration of catheter placement (days) | 6 | (5.0–7.0) | 13 | (7.5–17.0) | <0.001 |
Univariable Analysis (Crude) | Multivariable Analysis (Adjusted) | ||||||
---|---|---|---|---|---|---|---|
Parameter | Odds Ratio | 95% C.I. | p-Value | Odds Ratio | 95% C.I. | p-Value | |
Pre-op PSA | 1.008 | 0.998–1.018 | 0.099 | ||||
PSA density | 1.161 | 0.843–1.599 | 0.360 | ||||
* Console time (mins) | 1.009 | 1.003–1.015 | 0.002 ** | 1.007 | 1.000–1.013 | 0.036 * | |
* Nerve-sparing | Yes vs. No | 0.320 | 0.149–0.688 | 0.004 ** | |||
* Clinical T | 2.322 | 1.385–3.891 | 0.001 ** | 1.896 | 1.094–3.286 | 0.023 * | |
* Grade group-pathology | 1.391 | 1.031–1.877 | 0.031 * |
Intraoperative Leakage (n = 32) | p-Value | ||||
---|---|---|---|---|---|
OP year | Total | n | % | ||
Total | 230 | 32 | 13.9 | ||
2015 | 14 | 2 | 14.3 | 0.244 | |
2016 | 20 | 3 | 15.0 | ||
2017 | 21 | 1 | 4.8 | ||
2018 | 33 | 5 | 15.2 | ||
2019 | 34 | 10 | 29.4 | ||
2020 | 35 | 3 | 8.6 | ||
2021 | 20 | 4 | 20.0 | ||
2022 | 25 | 3 | 12.0 | ||
2023 | 25 | 1 | 3.5 |
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Chen, J.-K.; Chang, Y.-J.; Lin, C.-B.; Pan, Y.; Wang, P.-F. Occurrence and Impact of Intraoperative Anastomotic Leakage in Retzius-Sparing Robot-Assisted Radical Prostatectomy. Medicina 2025, 61, 886. https://doi.org/10.3390/medicina61050886
Chen J-K, Chang Y-J, Lin C-B, Pan Y, Wang P-F. Occurrence and Impact of Intraoperative Anastomotic Leakage in Retzius-Sparing Robot-Assisted Radical Prostatectomy. Medicina. 2025; 61(5):886. https://doi.org/10.3390/medicina61050886
Chicago/Turabian StyleChen, Jian-Kai, Yu-Jun Chang, Chi-Bo Lin, Yueh Pan, and Pai-Fu Wang. 2025. "Occurrence and Impact of Intraoperative Anastomotic Leakage in Retzius-Sparing Robot-Assisted Radical Prostatectomy" Medicina 61, no. 5: 886. https://doi.org/10.3390/medicina61050886
APA StyleChen, J.-K., Chang, Y.-J., Lin, C.-B., Pan, Y., & Wang, P.-F. (2025). Occurrence and Impact of Intraoperative Anastomotic Leakage in Retzius-Sparing Robot-Assisted Radical Prostatectomy. Medicina, 61(5), 886. https://doi.org/10.3390/medicina61050886