The Efficacy of Remineralizing Materials on Artificial Enamel Lesions: An In Vitro Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Sample Size Calculation
2.2. Tooth Collection and Enamel Surface Evaluation
2.3. Sample Preparation and Processing
2.4. Sample Grouping
- Group 1: Control group (CG).
- Group 2: Self-assembling peptide P11-4 group (P11-4).
- Group 3: 22,600 ppm fluoride varnish group (FV).
- Group 4: 20% nano-hydroxyapatite varnish group (nano-HA).
2.5. Measurement of Enamel Surface Hardness
2.6. Phase of Artificial Enamel Lesions
2.7. Application of Remineralizing Agents
2.8. Statistical Data Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Measurement No. | Group | n | Median Surface Hardness Values, HV | p-Value |
---|---|---|---|---|
I | CG | 9 | 328.60 | 0.758 |
P11-4 | 9 | 320.87 | ||
FV | 9 | 331.03 | ||
Nano-HA | 9 | 324.90 | ||
Total | 36 | 326.55 | ||
II | CG | 9 | 174.83 | 0.211 |
P11-4 | 9 | 163.47 | ||
FV | 9 | 172.73 | ||
Nano-HA | 9 | 178.93 | ||
Total | 36 | 173.78 | ||
III | CG | 9 | 173.43 | 0.036 |
P11-4 | 9 | 260.60 | ||
FV | 9 | 180.40 | ||
Nano-HA | 9 | 194.23 | ||
Total | 36 | 203.57 |
Comparative Measurements | Group | |||
---|---|---|---|---|
1 (CG) | 2 (P11-4) | 3 (FV) | 4 (Nano-HA) | |
Average Difference (SD), HV | ||||
I–II | 150.00 (48.02) * | 157.11 (40.62) * | 149.17 (62.54) * | 150.82 (33.45) * |
I–III | 134.03 (59.60) * | 69.81 (43.58) * | 127.99 (46.61) * | 111.10 (74.28) * |
II–III | 15.97 (41.89) | 87.30 (36.14) * | 21.18 (52.32) | 39.72 (92.85) |
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Klimaitė, G.; Vasiliauskas, A.; Grinkevičius, P.; Grinkevičienė, D.; Šapalas, D. The Efficacy of Remineralizing Materials on Artificial Enamel Lesions: An In Vitro Study. Medicina 2025, 61, 462. https://doi.org/10.3390/medicina61030462
Klimaitė G, Vasiliauskas A, Grinkevičius P, Grinkevičienė D, Šapalas D. The Efficacy of Remineralizing Materials on Artificial Enamel Lesions: An In Vitro Study. Medicina. 2025; 61(3):462. https://doi.org/10.3390/medicina61030462
Chicago/Turabian StyleKlimaitė, Gustė, Arūnas Vasiliauskas, Pranas Grinkevičius, Dominyka Grinkevičienė, and Deivydas Šapalas. 2025. "The Efficacy of Remineralizing Materials on Artificial Enamel Lesions: An In Vitro Study" Medicina 61, no. 3: 462. https://doi.org/10.3390/medicina61030462
APA StyleKlimaitė, G., Vasiliauskas, A., Grinkevičius, P., Grinkevičienė, D., & Šapalas, D. (2025). The Efficacy of Remineralizing Materials on Artificial Enamel Lesions: An In Vitro Study. Medicina, 61(3), 462. https://doi.org/10.3390/medicina61030462