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Volume 61
Issue 11
10.3390/medicina61112044
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Interstitial Lung Disease Secondary to Sjogren’s Syndrome and Antisynthetase Syndrome: Converging Disease Trajectories

by
Giuseppe Muscato
1,
Giulia Morina
1,
Evelina Fagone
1,
Mary Fruciano
1,
Elisa Gili
1,
Serafina Martella
1,
Stefano Palmucci
2,
Domenico Sambataro
3,
Carlo Vancheri
1 and
Gianluca Sambataro
4,*
1
Regional Referral Centre for Rare Lung Diseases, University Hospital Policlinico “G. Rodolico-San Marco”, Department of Clinical and Experimental Medicine, University of Catania, 95124 Catania, Italy
2
Unità Operativa Semplice Dipartimentale di Imaging Polmonare e Tecniche Radiologiche Avanzate (UOSD I.P.T.R.A.), University Hospital Policlinico “G. Rodolico-San Marco”, Department of Medical Surgical Sciences and Advanced Technologies “GF Ingrassia”, University of Catania, 95124 Catania, Italy
3
Artroreuma S.R.L., Outpatient Clinic Associated with the Regional Health System, 95030 Mascalucia, Italy
4
Department of Medicine and Surgery, University of Enna “Kore”, 94100 Enna, Italy
*
Author to whom correspondence should be addressed.
Medicina 2025, 61(11), 2044; https://doi.org/10.3390/medicina61112044 (registering DOI)
Submission received: 10 October 2025 / Revised: 7 November 2025 / Accepted: 12 November 2025 / Published: 15 November 2025
(This article belongs to the Section Pulmonology)
Versions Notes

Abstract

Background and Objectives: Interstitial lung disease is one of the main causes of mortality in Sjögren’s Syndrome (SjS) and Anti-Synthetase Syndrome (ASyS). The objective of the study is to compare clinical, serological and radiological features of these conditions, as well as their prognosis. Materials and Methods: we retrospectively enrolled 34 SjS-ILD and 33 ASyS-ILD patients. The two cohorts were jointly followed by rheumatologists and pulmonologists for at least two years. Results: From a clinical point of view, ASyS-ILD patients showed a greater prevalence of myositis (18.2% vs. 2.3%, p = 0.04), whereas more SjS patients had sicca syndrome (85.3% vs. 9.1%, p < 0.001). No other clinical differences were noted. From a serological point of view, ASyS-ILD patients had a greater proportion of antinuclear antibody positivity with a cytoplasmic pattern (24.9% vs. 2.9%, p = 0.005) and positivity for Anti-Synthetase Antibodies (ASA), which were not found in the SjS cohort. SjS-ILD patients were mainly positive for anti-Ro52kD (61.8% vs. 27.3%, p = 0.002). No significant differences were noted in radiological pattern of ILD, functional values, disease progression and prognosis. Conclusions: SjS-ILD and ASyS patients show several common features. It could be hypothesized that some patients classified as SjS-ILD could have undetectable or unknown ASA, and the upcoming ASyS classification criteria may be useful in highlighting these patients for deeper research.
Keywords: Sjogren Syndrome; Antisynthetase Syndrome; interstitial lung diseases; CTD-ILD; anti-Ro52kD antibody Sjogren Syndrome; Antisynthetase Syndrome; interstitial lung diseases; CTD-ILD; anti-Ro52kD antibody

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MDPI and ACS Style

Muscato, G.; Morina, G.; Fagone, E.; Fruciano, M.; Gili, E.; Martella, S.; Palmucci, S.; Sambataro, D.; Vancheri, C.; Sambataro, G. Interstitial Lung Disease Secondary to Sjogren’s Syndrome and Antisynthetase Syndrome: Converging Disease Trajectories. Medicina 2025, 61, 2044. https://doi.org/10.3390/medicina61112044

AMA Style

Muscato G, Morina G, Fagone E, Fruciano M, Gili E, Martella S, Palmucci S, Sambataro D, Vancheri C, Sambataro G. Interstitial Lung Disease Secondary to Sjogren’s Syndrome and Antisynthetase Syndrome: Converging Disease Trajectories. Medicina. 2025; 61(11):2044. https://doi.org/10.3390/medicina61112044

Chicago/Turabian Style

Muscato, Giuseppe, Giulia Morina, Evelina Fagone, Mary Fruciano, Elisa Gili, Serafina Martella, Stefano Palmucci, Domenico Sambataro, Carlo Vancheri, and Gianluca Sambataro. 2025. "Interstitial Lung Disease Secondary to Sjogren’s Syndrome and Antisynthetase Syndrome: Converging Disease Trajectories" Medicina 61, no. 11: 2044. https://doi.org/10.3390/medicina61112044

APA Style

Muscato, G., Morina, G., Fagone, E., Fruciano, M., Gili, E., Martella, S., Palmucci, S., Sambataro, D., Vancheri, C., & Sambataro, G. (2025). Interstitial Lung Disease Secondary to Sjogren’s Syndrome and Antisynthetase Syndrome: Converging Disease Trajectories. Medicina, 61(11), 2044. https://doi.org/10.3390/medicina61112044

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