The Impact of Platelet-Rich Plasma Application during Cesarean Section on Wound Healing and Postoperative Pain: A Single-Blind Placebo-Controlled Intervention Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Population
2.2. Surgery and Postoperative Treatment
2.3. Scar Quality Assessment
2.4. Quality of Life Assessment
2.5. PRP Preparation
2.6. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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PRP Group n = 23 | Placebo Group n = 23 | p-Value | |
---|---|---|---|
Age (years) | 31.1 ± 5.2 | 31.1 ± 5.2 | 0.700 |
BMI (kg/m2) | 26.6 ± 2.9 | 28.1 ± 3.4 | 0.191 |
Nullipara | 18 (78.3%) | 20 (87.0%) | 0.699 |
Multipara | 5 (21.7%) | 3 (13.0%) | |
Hypothyroidism | 10 (43.5%) | 9 (39.1%) | 0.765 |
GBS colonization | 10 (43.5%) | 3 (13.0%) | 0.022 |
PRP Group n = 23 | Placebo Group n = 23 | p-Value | |
---|---|---|---|
Indications for cesarean section: | 0.957 | ||
Breech presentation | 5 (21.7%) | 4 (17.4%) | |
Psychiatric (tocophobia) | 6 (26.1%) | 5 (21.7%) | |
Long infertility treatment | 4 (17.4%) | 3 (13%) | |
Fetal macrosomia | 1 (4.3%) | 1 (4.3%) | |
Previous CS because of lack of delivery progress | 2 (8.7%) | 2 (8.7%) | |
Neurologic | 1 (4.3%) | 4 (17.4%) | |
Ophthalmologic | 2 (8.7%) | 2 (8.7%) | |
Orthopedic | 1 (4.3%) | 0 | |
Cardiologic | 1 (4.3%) | 2 (8.7%) | |
Gestational age at delivery (weeks) | 38.9 ± 0.29 | 39.0 ± 0.48 | 0.323 |
Neonatal birth weight (g) | 3460 ± 391 | 3474 ± 343 | 0.930 |
Blood loss: | 0.609 | ||
300 mL | 3 (13%) | 4 (17.4%) | |
350 mL | 17 (73.9%) | 13 (56.5%) | |
400 mL | 3 (13%) | 5 (21.7%) | |
450 mL | 0 | 1 (4.3%) | |
Duration of patient’s hospitalization (days) | 5.61 ± 1.31 | 5.35 ± 1.27 | 0.299 |
Parameter | PRP Group n = 23 | Placebo Group n = 23 | p-Value |
---|---|---|---|
Day 8 | |||
Total amount | 16.96 ± 1.52 | 17.57 ± 1.85 | 0.230 |
Vascularity | 3.57 ± 0.84 | 3.65 ± 0.94 | 0.732 |
Pigmentation | 3.00 ± 0.6 | 2.83 ± 0.83 | 0.446 |
Thickness | 2.61 ± 0.66 | 2.91 ± 0.6 | 0.099 |
Relief | 2.04 ± 0.64 | 1.96 ± 0.64 | 0.610 |
Pliability | 3.17 ± 0.58 | 3.22 ± 0.85 | 0.842 |
Surface area | 2.57 ± 0.59 | 3.00 ± 0.6 | 0.015 |
Day 30 | |||
Total amount | 17.00 ± 1.76 | 18.09 ± 2.00 | 0.033 |
Vascularity | 3.57 ± 0.84 | 3.65 ± 0.94 | 0.732 |
Pigmentation | 3.22 ± 0.6 | 3.04 ± 0.83 | 0.446 |
Thickness | 2.74 ± 0.62 | 3.13 + 0.69 | 0.035 |
Relief | 1.96 ± 0.37 | 2.26 ± 0.54 | 0.076 |
Pliability | 3.17 ± 0.65 | 3.26 ± 0.81 | 0.691 |
Surface area | 2.35 ± 0.71 | 2.74 ± 0.69 | 0.028 |
Day 90 | |||
Total amount | 14.91 ± 1.54 | 16.09 ± 1.68 | 0.021 |
Vascularity | 2.65 ± 0.65 | 2.78 ± 0.85 | 0.607 |
Pigmentation | 2.48 ± 0.59 | 2.48 ± 0.90 | 0.999 |
Thickness | 2.57 ± 0.73 | 3.00 ± 0.52 | 0.019 |
Relief | 2.13 ± 0.55 | 2.30 ± 0.56 | 0.309 |
Pliability | 2.74 ± 0.75 | 2.74 ± 0.69 | 0.999 |
Surface area | 2.35 ± 0.49 | 2.78 ± 0.52 | 0.015 |
Parameter | PRP Group n = 23 | Placebo Group n = 23 | p-Value |
---|---|---|---|
Day 8 | |||
Total amount | 15.61 ± 1.08 | 16.17 ± 1.44 | 0.180 |
Vascularity | 3.17 ± 0.58 | 3.13 ± 0.63 | 0.820 |
Pigmentation | 2.52 ± 0.59 | 2.65 ± 0.57 | 0.491 |
Thickness | 3.00 ± 0.60 | 3.17 ± 0.49 | 0.333 |
Relief | 1.65 ± 0.49 | 1.65 ± 0.57 | 0.999 |
Pliability | 2.65 ± 0.65 | 2.83 ± 0.72 | 0.340 |
Surface area | 2.61 ± 0.72 | 2.74 ± 0.54 | 0.437 |
Day 30 | |||
Total amount | 15.91 ± 1.24 | 17.13 ± 1.58 | 0.004 |
Vascularity | 3.09 ± 0.60 | 3.13 ± 0.63 | 0.820 |
Pigmentation | 2.87 ± 0.69 | 3.13 ± 0.69 | 0.169 |
Thickness | 3.00 ± 0.60 | 3.39 + 0.72 | 0.030 |
Relief | 1.83 ± 0.49 | 1.78 ± 0.60 | 0.806 |
Pliability | 2.65 ± 0.65 | 2.83 ± 0.72 | 0.340 |
Surface area | 2.48 ± 0.67 | 2.87 ± 0.63 | 0.021 |
Day 90 | |||
Total amount | 13.39 ± 1.53 | 14.74 ± 2.11 | 0.002 |
Vascularity | 2.48 ± 0.59 | 2.87 ± 0.69 | 0.042 |
Pigmentation | 1.87 ± 0.69 | 1.96 ± 0.56 | 0.646 |
Thickness | 2.65 ± 0.71 | 3.04 ± 0.64 | 0.030 |
Relief | 1.83 ± 0.58 | 2.00 ± 0.91 | 0.327 |
Pliability | 2.30 ± 0.56 | 2.39 ± 0.50 | 0.633 |
Surface area | 2.26 ± 0.45 | 2.48 ± 0.51 | 0.196 |
PRP Group n = 23 | Placebo Group n = 23 | p-Value | |
---|---|---|---|
Morphine: | |||
Mean number of doses | 9.57 ± 2.86 | 10.09 ± 1.95 | 0.738 |
Total dose number | 30.87 ± 9.2 | 35.43 ± 10.5 | 0.132 |
Paracetamol: | 0.006 | ||
1 dose per day | 11 (47.8%) | 3 (13%) | |
2 doses per day | 12 (52.2%) | 15 (65.2%) | |
3 doses per day | 0 | 5 (21.7%) | |
The additional use of ketoprofen | 0 | 6 (26.1%) | 0.096 |
VAS score (mean ± SD): | |||
Immediately after surgery | 3.3 ± 2.23 | 3.96 ± 2.08 | 0.299 |
6 h after surgery | 4.96 ± 1.49 | 5.3 ± 1.52 | 0.465 |
12 h after surgery | 4.96 ± 1.36 | 5.13 ± 1.36 | 0.657 |
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Barwijuk, M.; Pankiewicz, K.; Gałaś, A.; Nowakowski, F.; Gumuła, P.; Jakimiuk, A.J.; Issat, T. The Impact of Platelet-Rich Plasma Application during Cesarean Section on Wound Healing and Postoperative Pain: A Single-Blind Placebo-Controlled Intervention Study. Medicina 2024, 60, 628. https://doi.org/10.3390/medicina60040628
Barwijuk M, Pankiewicz K, Gałaś A, Nowakowski F, Gumuła P, Jakimiuk AJ, Issat T. The Impact of Platelet-Rich Plasma Application during Cesarean Section on Wound Healing and Postoperative Pain: A Single-Blind Placebo-Controlled Intervention Study. Medicina. 2024; 60(4):628. https://doi.org/10.3390/medicina60040628
Chicago/Turabian StyleBarwijuk, Michał, Katarzyna Pankiewicz, Aleksander Gałaś, Filip Nowakowski, Patrycja Gumuła, Artur J. Jakimiuk, and Tadeusz Issat. 2024. "The Impact of Platelet-Rich Plasma Application during Cesarean Section on Wound Healing and Postoperative Pain: A Single-Blind Placebo-Controlled Intervention Study" Medicina 60, no. 4: 628. https://doi.org/10.3390/medicina60040628
APA StyleBarwijuk, M., Pankiewicz, K., Gałaś, A., Nowakowski, F., Gumuła, P., Jakimiuk, A. J., & Issat, T. (2024). The Impact of Platelet-Rich Plasma Application during Cesarean Section on Wound Healing and Postoperative Pain: A Single-Blind Placebo-Controlled Intervention Study. Medicina, 60(4), 628. https://doi.org/10.3390/medicina60040628