Preoperative Albumin-to-Alkaline Phosphatase Ratio as an Independent Predictor of Lymph Node Involvement in Penile Cancer
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design
2.2. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Overall | AAPR ≤ 0.53 | AAPR > 0.53 | p Value | |
---|---|---|---|---|
n = 42 | n = 18 | n = 24 | ||
Age, mean (SD) | 63.6 (12.9) | 65.3 (13.7) | 62.1 (11.3) | 0.46 |
Smoking, n (%) | ||||
Never | 8 (19.1) | 3 (16.7) | 5 (20.8) | 0.26 |
Current | 14 (33.3) | 6 (33.3) | 8 (33.3) | |
Former | 20 (47.6) | 9 (50.0) | 11 (45.9) | |
HPV, n (%) | ||||
High Risk | 19 (45.2) | 7 (38.9) | 12 (50.0) | 0.49 |
Intermediate-Low Risk | 1 (2.4) | 1 (5.6) | 0 (0.0) | |
No | 4 (9.5) | 2 (11.1) | 2 (8.3) | |
Unknown | 18 (42.9) | 8 (44.4) | 10 (41.7) | |
Diabetes, n (%) | 8 (19.0) | 3 (16.6) | 5 (20.8) | 0.38 |
Hypertension, n (%) | 18 (42.8) | 7 (38.8) | 11 (45.8) | 0.56 |
ASA score, median (IQR) | 2 (2–2) | 2 (2–2) | 2 (2–2) | 0.78 |
Charlson Comorbidity Index, median (IQR) | 3 (2–4) | 3 (2–4) | 3 (2–4) | 0.87 |
Primary tumor surgery, n (%) | ||||
Total penectomy | 7 (16.7) | 3 (16.7) | 4 (16.6) | 0.23 |
Partial Penectomy | 21 (50.0) | 8 (44.4) | 13 (54.2) | |
Penile-sparing surgery | 14 (33.3) | 7 (38.9) | 7 (29.2) | |
Clinical N stage, n (%) | ||||
cNx | 1 (2.4) | 1 (5.5) | 0 (0) | 0.03 |
cN0 | 18 (42.8) | 5 (27.8) | 13 (54.2) | |
cN+ | 23 (54.8) | 12 (66.7) | 11 (45.8) | |
Pathologic T stage, n (%) | ||||
pTa/T1 | 7 (16.7) | 3 (16.7) | 4 (16.7) | 0.08 |
pT2 | 13 (30.9) | 5 (27.8) | 8 (33.3) | |
pT3 | 22 (52.4) | 10 (55.5) | 12 (50.0) | |
pT4 | 0 (0.0) | 0 (0.0) | 0 (0.0) | |
Primary tumor grade, n (%) | ||||
G1/G2 | 16 (38.1) | 7 (38.9) | 9 (37.5) | 0.88 |
G3/G4 | 26 (61.9) | 11 (61.1) | 15 (62.5) | |
Pathologic N stage, n (%) | ||||
pN0 | 12 (28.6) | 3 (16.7) | 9 (37.5) | 0.02 |
pN+ | 30 (71.4) | 15 (83.3) | 15 (62.5) | |
Lymphovascular invasion, n (%) | ||||
No | 19 (45.2) | 8 (44.4) | 11 (45.8) | 0.67 |
Yes | 23 (54.8) | 10 (55.6) | 13 (54.2) | |
Perineural invasion, n (%) | ||||
No | 11 (26.2) | 5 (27.8) | 6 (25.0) | 0.38 |
Yes | 13 (30.9) | 6 (33.3) | 7 (29.2) | |
Unknown | 18 (42.9) | 7 (38.9) | 11 (45.8) | |
Positive Margins, n (%) | 0 (0.0) | 0 (0.0) | 0 (0.0) | - |
Variable | Univariable Analysis | Multivariable Analysis | ||||||
---|---|---|---|---|---|---|---|---|
OR * | 95.0% CI * | OR * | 95.0% CI * | |||||
Lower | Higher | p Value | Lower | Higher | p Value | |||
Primary tumor grade | ||||||||
G1/G2 | Ref. | - | - | - | - | - | - | - |
G3/G4 | 1.73 | 0.78 | 2.1 | 0.42 | ||||
Lymphovascular Invasion | ||||||||
No | Ref. | - | - | - | Ref. | - | - | - |
Yes | 4.88 | 1.97 | 8.90 | 0.003 | 5.38 | 1.47 | 9.93 | 0.022 |
Clinical N stage | ||||||||
cN0 | Ref. | - | - | - | Ref. | - | - | - |
cN+ | 16.76 | 6.89 | 39.02 | <0.001 | 13.68 | 4.37 | 43.90 | 0.009 |
Albumin-to-Alkaline phosphatase ratio | ||||||||
>0.53 | Ref. | - | - | - | Ref. | - | - | - |
≤0.53 | 3.91 | 1.89 | 9.71 | 0.014 | 3.61 | 1.23 | 12.71 | 0.032 |
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Tufano, A.; Napolitano, L.; Barone, B.; Pezone, G.; Alvino, P.; Cilio, S.; Buonerba, C.; Canciello, G.; Passaro, F.; Perdonà, S. Preoperative Albumin-to-Alkaline Phosphatase Ratio as an Independent Predictor of Lymph Node Involvement in Penile Cancer. Medicina 2024, 60, 414. https://doi.org/10.3390/medicina60030414
Tufano A, Napolitano L, Barone B, Pezone G, Alvino P, Cilio S, Buonerba C, Canciello G, Passaro F, Perdonà S. Preoperative Albumin-to-Alkaline Phosphatase Ratio as an Independent Predictor of Lymph Node Involvement in Penile Cancer. Medicina. 2024; 60(3):414. https://doi.org/10.3390/medicina60030414
Chicago/Turabian StyleTufano, Antonio, Luigi Napolitano, Biagio Barone, Gabriele Pezone, Pierluigi Alvino, Simone Cilio, Carlo Buonerba, Giuseppina Canciello, Francesco Passaro, and Sisto Perdonà. 2024. "Preoperative Albumin-to-Alkaline Phosphatase Ratio as an Independent Predictor of Lymph Node Involvement in Penile Cancer" Medicina 60, no. 3: 414. https://doi.org/10.3390/medicina60030414