Treatment of Asymptomatic Bacteriuria after Kidney Transplantation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Abstract
:1. Introduction
2. Methods
2.1. Types of Studies, Participants, and Interventions
2.2. Types of Outcome Measures
2.2.1. Primary Outcomes
2.2.2. Secondary Outcomes
2.3. Search Strategy
2.4. Assessment of Risk of Bias in Included Studies
2.5. Data Collection and Analysis
3. Results
3.1. Description of Studies
3.2. Primary Outcomes
3.2.1. Symptomatic UTI
3.2.2. Antimicrobial resistance
3.3. Secondary Outcomes
3.3.1. Graft Function
3.3.2. Hospitalization due to UTI
3.3.3. Persistence or Relapse of Asymptomatic Bacteriuria
3.3.4. Other Outcomes
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Study | Study Type | Location | Course of Antibiotics in Treatment Group | Number of Patients (Antibiotics vs. No Treatment) | Enrollment Time (Post-Transplantation) | Follow-Up Duration | Outcome: Symptomatic Urinary Tract Infection (Antibiotics vs. no Treatment) |
---|---|---|---|---|---|---|---|
Moradi 2005 [22] | quasi-RCT | Iran | 10 days | 88 (43 vs. 45) | >1 year | 12 months | 20.9% vs. 30.4% |
Origuen 2016 [23] | RCT | Spain | 3–7 days | 112 (53 vs. 59) | >2 months | 24 months | 20.8% vs. 18.6% |
Sabé 2019 [24] | RCT | Spain | 5–7 days | 87 (41 vs. 46) | Post-operation after urinary catheter removal | 12 months | 26.8% vs. 15.2% |
Coussement 2021 [25] | RCT | France and Belgium | 10 days | 199 (100 vs. 99) | >2 months | 12 months | 27% vs. 31.3% |
Antonio 2022 [26] | RCT | México | 5 days | 80 (40 vs. 40) | Post-operation after urinary catheter removal | 63 days | 25% vs. 10% |
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Rao, Z.; Wang, Z.; Tang, M.; Shen, L.; Zhang, K. Treatment of Asymptomatic Bacteriuria after Kidney Transplantation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Medicina 2023, 59, 1600. https://doi.org/10.3390/medicina59091600
Rao Z, Wang Z, Tang M, Shen L, Zhang K. Treatment of Asymptomatic Bacteriuria after Kidney Transplantation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Medicina. 2023; 59(9):1600. https://doi.org/10.3390/medicina59091600
Chicago/Turabian StyleRao, Zhengsheng, Zhiling Wang, Ming Tang, Linguo Shen, and Keqin Zhang. 2023. "Treatment of Asymptomatic Bacteriuria after Kidney Transplantation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials" Medicina 59, no. 9: 1600. https://doi.org/10.3390/medicina59091600