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Review

Post Treatment Sexual Function and Quality of Life of Patients Affected by Cervical Cancer: A Systematic Review

by
Stefano Cianci
1,*,
Mattia Tarascio
2,
Martina Arcieri
3,4,
Marco La Verde
5,
Canio Martinelli
1,
Vito Andrea Capozzi
6,
Vittorio Palmara
1,
Ferdinando Gulino
7,
Salvatore Gueli Alletti
8,
Giuseppe Caruso
9,
Stefano Restaino
4,
Giuseppe Vizzielli
4,
Carmine Conte
9,
Marco Palumbo
9 and
Alfredo Ercoli
1
1
Obstetrics and Gynecology Unit, Department of Human Pathology of Adult and Childhood “G. Barresi”, University of Messina, 98124 Messina, Italy
2
Obstetrics and Gynecology Unit, Department of Woman and Child, Azienda Sanitaria Provinciale di Catania, 95124 Catania, Italy
3
Department of Biomedical, Dental, Morphological and Functional Imaging Science, University of Messina, 98122 Messina, Italy
4
Department of Medical Area (DAME), Clinic of Obstretics and Gynecology “Santa Maria della Misericordia”, University Hospital Azienda Sanitaria Universitaria Friuli Centrale, University of Udine, 33100 Udine, Italy
5
Obstetrics and Gynecology Unit, Department of Woman, Child and General and Specialized Surgery, University of Campania Luigi Vanvitelli, 80138 Napoli, Italy
6
Department of Medicine and Surgery, University Hospital of Parma, 43125 Parma, Italy
7
Department of Obstetrics and Gynaecology, Azienda di Rilievo Nazionale e di Alta Specializzazione (ARNAS) Garibaldi Nesima, 95124 Catania, Italy
8
Obstetrics and Gynecology Unit, Department of Woman and Child, Ospedale Buccheri La Ferla Fatebenefratelli, 90123 Palermo, Italy
9
Department of General Surgery and Medical Surgical Specialties, Gynecological Clinic, University of Catania, 95123 Catania, Italy
*
Author to whom correspondence should be addressed.
Medicina 2023, 59(4), 704; https://doi.org/10.3390/medicina59040704
Submission received: 9 February 2023 / Revised: 28 March 2023 / Accepted: 29 March 2023 / Published: 4 April 2023
(This article belongs to the Special Issue Effects of Abdominal Hysterectomy on Gynecological Patients)
Browse Figure
Review Reports Versions Notes

Abstract

:
Introduction: The aim of this study is to analyze the available scientific evidence regarding the quality of life (QoL) and sexual function (SF) in patients affected by cervical cancer (CC) after surgical and adjuvant treatments. Materials and Methods: Preliminary research was conducted via electronic database (MEDLINE, PubMed and Cochrane Library) with the use of a combination of the following keywords: SF, QoL, and CC. The principal findings considered in the present review were the study design, the number of patients included in each study, the information about the malignancy (histology and stage of disease), the questionnaires administered, and the principal findings concerning SF and QoL. Results: All studies were published between 2003–2022. The studies selected consisted of one randomized control study, seven observational studies (three prospective series), and nine case control studies. The scores used were focused on SF, QOL, fatigue, and psychological aspects. All studies reported a decreased SF and QOL. The most developed questionnaires were the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30), the Female Sexual Function Index (FSFI), the Hospital Anxiety and Depression scale (HADS), and the Female Sexual Distress Scale (FSDS). Discussion: All studies reported a decreased SF and QOL. In addition to the perception of body image, several factors coexist in influencing the outcomes such as the physical, hormonal, psychological. Conclusions: Sexual dysfunction after CC treatment has a multifactorial aetiology which negatively affects the quality of life. For these reasons, it is important to follow and support patients with a multidisciplinary team (doctors, nurses, psychologists, dieticians) before and after therapy. This type of tailored therapeutic approach should become a standard. Women should be informed about possible vaginal changes and menopausal symptoms after surgery and on the positive effects of psychological therapy.

1. Introduction

Cervical cancer (CC) is the fourth most common neoplasm among women, with a highest incidence in young women [1]. In 2019, a total of 565,541 new cases and 280,479 deaths caused by cervical cancer were registered [2]. Persistent human papillomavirus infection is the most important cause leading to cervical cancer. The incidence and mortality of CC differs geographically and is related to the Human Development Index (HDI). Countries with low and middle HDI have worse rates than those with high HDI [3].
In recent years, thanks to the strengthening of screening programmers, through the Pap Test, the Human Papilloma Virus (HPV) DNA test and the HPV vaccination, there has been a significant decrease in incidence and an increase in survival rates for CC: [4,5,6,7,8,9].
In May 2018, the World Health Organization (WHO) has launched a global call for action to eradicate cervical cancer [10,11,12,13]. The WHO recommended two doses of the HPV vaccine for girls aged 9 to 14. Vaccination is primarily recommended for younger individuals, preferably before the beginning of sexualactivity. The HPV vaccine’s objective is to prevent HPV infection and HPV related-cancer [14]. The WHO’s strategy for the elimination of cervical cancer has a target of 90% of all adolescent girls being vaccinated against HPV by 2030. Nevertheless, despite the efforts to strengthen screening and vaccination programs, the goal is still far from being achieved [15,16,17,18,19,20,21,22,23]. Currently, radical hysterectomy (RH), radiotherapy, chemotherapy, or a combination of both are considered as the standard treatment, especially for early stage CC [24]. However, medical and surgical procedures could be related to severe post-treatment dysfunctions with regard to sexual, intestinal, and vesical functions [25,26,27].
A significant percentage of CC patients experienced frequent sequelae after treatment, such as decreased sexual desire, vaginal dryness, dyspareunia, depression, and anxiety. These aspects acquire greater relevance considering that the most CC patients are relatively young. Currently, the quality of life (QoL) of cancer patients has gained more relevance than in the past, and the efficacy of treatment is not the only aspect to evaluate. In this context, especially for young patients, achieving regular sexual function is extremely important [28,29]. However, the limits with CC are that the treatment options to reduce sexual dysfunction and menopausal symptoms (i.e., local or systemic estrogen, nonhormonal treatments, laser therapy, lubricants) are extremely limited and are not always effective for this subgroup of patients [30,31,32,33,34].
Many recent reviews focused on quality of life and the sexual function of patients with cervical cancer and have only evaluated the sexual dysfunctions of patients undergoing chemo- radiotherapy plus interventional radiotherapy [35,36,37]. The studies currently available in the literature are poor and heterogeneous, and their results are often conflicting; therefore, no definitive recommendations can be formulated.
Furthermore, it is unclear whether the dysfunction is attributable to surgical sequelae, radiotherapy, chemotherapy, or psychological aspects related to cancer. In fact, psychological factors alone caused by the cancer diagnosis may also negatively influence sexual functioning independently of the type of treatment or stage of cancer.
During oncological evaluation and follow-up, information and communication about sexual issues is often lacking. The aim of this study is to analyze the available scientific evidence regarding QoL and especially the sexual function (SF) of patients affected by CC after surgical and/or medical and radiological treatment.

2. Materials and Methods

This systematic research has been performed in agreement with the Preferred reporting items for Systematic reviews and Meta-analysis statement (PriSMa). A comprehensive literature research on electronic databases (MEDLINE, PubMed and Cochrane Library) was conducted from inception until July 2022.
The primary research strategy was identified with the use of a combination of the following medical relevant headings terms (MeSH) and keywords: “sexuality and cervical cancer”, “sexual function and cervical cancer”, “cervical cancer and sexual dysfunction”, “sexuality and gynecological cancer”, “sexual dysfunction and gynecological cancer”, “sexual dysfunction and cervical cancer”, “cervical cancer and Quality of Life”, and “gynecologic cancer and Quality of Life”. Studies evaluated that were not in line with the aim of the study, case reports, papers based on animal models or laboratory studies, and non-English language articles were excluded.
The electronic research and the eligibility of the studies were independently assessed by two of the authors (MA, MT). In addition, references in the included articles were reviewed to identify additional eligible articles. Differences were discussed with a third reviewer (SC) for data extraction.
The main findings considered in the present review were the study design, the number of patients included in each study, information about the pathology (histology and stage of disease), the questionnaires administered, and the principal findings concerning SF and QoL.
The data extracted were the author, year of publication, number of patients included, study population characteristics (age, comorbidity, social status), main outcomes, main findings, and sexual and quality of life questionnaires. After the initial research, a total of 12177 titles were extracted from the Pubmed database, MEDLINE, and Cochrane Library using the keywords previously mentioned. After the first revision, 122 unique studies were extracted. After further revision, 25 articles were selected, out of which 18 studies were ultimately eligible for the present review following a full text evaluation. The selection process is illustrated in Figure 1. Considering the heterogeneity of the studies in terms of methodology, population, and the different score administered, a cumulative analysis was not applicable. However, the main outcomes of different studies were analyzed.

3. Results

3.1. Study Characteristics

A total of eighteen studies treating both SF and QoL in patients affected by CC were extracted. All studies were published between 2003 and 2022 and are reported with the main findings and characteristics shown in Table 1.
The selected studies were represented by one randomized study, eight observational studies (three prospective studies), and nine case control studies. Different validated scores were used to assess SF and QoL in the different studies; however, the most frequently administered questionnaires were the European Organization and Treatment of Cancer QLQ-C30 (EORTC QLQ-C30), the Quality of Life Questionnaire for Cervical Cancer (EORTC QLQ-CX24), the Female Sexual Function Index (FSFI), the Hospital Anxiety and Depression scale (HAD S), the Sexual Function-Vaginal changes Questionnaire (SVQ), and the Female Sexual Distress Scale (FSDS).

3.2. Study Descriptions

The study of Kirchheiner et al. [38] reported the largest series, with 1045 cases, and considered women affected by CC from stage FIGO I to IVB who underwent to chemoradiotherapy and image-guided adaptive brachytherapy. The aim of the study was to prospectively investigate sexual outcomes before and after treatment. The primary objective was to report patient sexual activity, vaginal functioning problems during intercourse, and sexual enjoyment within the first 5 years of follow-up. They assessed the SF at baseline and every 3 months during the first year, and thereafter every 6 months in the second and third year, and yearly after that using EORTC-QLQ-CX24. A total of 622/1045 (60%) patients were sexually active after treatment, but many of them complained of different aspects of SF during follow up: 39% reported vaginal dryness, 38% reported vaginal shortening, 35% reported vaginal tightening, and 34% reported pain during sexual intercourse.
These symptoms were negatively correlated with sexual enjoyment (p ≤ 0.001). Regular hormonal replacement therapy (HRT) was associated with a significant improvement in vaginal dryness (p = 0.015), vaginal shortening (p = 0.024), and pain during intercourse (p = 0.003).
Novackova et al. [39] compared QoL and SF (EORTC QLQ-CX24, EORTC QLQ-CX30, FSFI) in patients with early-stage CC before and after a nerve sparing radical hysterectomy. The results showed a statistically significant decrease in arousal, orgasm, desire, lubrication, satisfaction, and pain after surgery. The results of the EORTC QLQ indicated a decrease in sexual functioning after surgery, but no changes in sexual activity, sexual enjoyment, or concern.
The study by Park et al. [40] reported 860 cases (women with a history of CC, stage FIGO I to IVA) and 494 controls. The authors investigated the QoL and SF through EORTC QLQ-C30. They reported that women affected by CC had greater impaired social functioning and more severe urinary symptoms, constipation, and diarrhea than controls (p < 0.01). Moreover, CC survivors had more severe menopausal symptoms and worse self-body image. Furthermore, SF was impaired, as women with CC had more anxiety about sexual performance and worse vaginal functioning (p < 0.01). The sub-analysis performed, based on the treatment received, demonstrated that sexual dysfunction was more severe in women who underwent radiotherapy. Moreover, patients who received both surgery and radiotherapy experienced a higher decrease in SF than women that only had surgery. In addition, chemotherapy was linked to dyspareunia (odds ratio [OR]), 1.6; 95% CI, 1.4–2.0), anxiety about sexual performance (OR, 1.7; 95% CI, 1.4–2.1), and insufficient vaginal lubrication (OR, 1.3; 95% CI, 1.1–1.6) in a multivariate analysis. Finally, a high association between sexual problems and a QOL decrease in CC cancer survivors was recorded.
Jensen et al. [41] prospectively compared 173 patients with early-stage CC, negative lymph node submitted to radical hysterectomy (RH), and pelvic lymphadenectomy to 328 controls. The authors assessed SF using the SVQ, a validated self-assessment questionnaire developed to evaluate sexual and vaginal disorders after gynecologic cancer. CC patients experienced low or no sexual interest and severe lack of vaginal lubrification more frequently than controls during the first 2 years after surgery.
Compared with controls, CC patients experienced significantly severe orgasmic dysfunction and uncomfortable sexual intercourse due to a reduced vaginal length during the first 6 months after radical hysterectomy, reporting severe dyspareunia during the first 3 months (RR = 3.5, CI = 1.2–10.2 [5 weeks]; RR = 2.5, CI = 1.0–6.5 [3 months] and lower sexual satisfaction during the 5 weeks after surgery. However, six months after surgery, the proportion of patients who were sexually active was similar to that of the control group of the corresponding age. Comparing SF retrospectively before and after surgery, cancer survivors complained of a higher level of sexual dysfunction 12 months after surgery; 91% of CC patients were sexually active before and after surgery, with a decrease in sexual activity frequency (p = 0.008) and sexual interest.
Ljuca et al. [42] evaluated 35 patients with advanced CC who had exclusive chemo-radiotherapy to assess their SF before and after treatment using the EORTC-QLQ-Cx, a questionnaire specifically elaborated for CC. Women answered questions about SF in the period before treatment and 12 months after the end of chemo-radiotherapy. After therapy, vaginal dysfunction was statistically reduced (p < 0.0001). However, there was no significant difference in SF. Fourteen patients (40%) did not have sexual intercourse either before or after irradiation. Dyspareunia was significantly reduced (p = 0.009) after therapy, while vaginal function in terms of lubrification improved significantly.
Bakker et al. [43] analyzed 194 sexually active patients and 58 sexually inactive CC survivors, who underwenteither RH with pelvic lymphadenectomy or radiotherapy. Sexual distress was reported by 38% of all participants associated with sexual pain, anxiety, and body image concerns. Sexually inactive cervical cancer patients were significantly older, in a stable and long-term relationship, were relatively more often diagnosed with FIGO stage IIB or higher, and were more often treated with RT compared to sexually active women.
The severity of vaginal sexual symptoms reported by sexually active participants was significantly different according to the treatment received: patients who underwent radiotherapy/brachytherapy reported significantly higher vaginal discomfort than women who underwent RH (p = 0.004) and RH/radiotherapy (p = 0.008). However, no differences were recorded compared to women treated with RH/radiotherapy/brachytherapy (p = n.s.). Higher levels of sexual distress were significantly correlated to vaginal symptoms such as dryness, sexual pain, worry, anxiety, depression, and body image concerns.
Aerts et al. [44] prospectively compared the SF of 31 women affected by CC who underwent RH, 93 who underwent simple hysterectomy due to a benign gynecological condition, and 93 healthy controls. In the cases group, only 25 women completed the surveys at 6 months after surgery (25/50, 50%), 14 women completed it at 1 year (14/50, 28%), and 12 women completed it at the 2 year follow-up (12/50, 24%). No difference in SF was recorded in CC survivors before and after surgery compared to women who underwent hysterectomy for a benign condition. However, the comparison with healthy controls, preoperatively and postoperatively, showed significantly more sexual dysfunction in the cancer group. Introital dyspareunia was significantly higher in women with CC before treatment (p < 0.01), and it persisted during the 2-year follow-up; furthermore, the intensity of orgasm and sexual arousal was significantly reduced at 1 year of follow up. CC survivors reported more deep dyspareunia (p < 0.01) and abdominal pain during intercourse at 2 years after treatment (p < 0.01) than healthy women. Moreover, worse psychological functioning before surgery and at 6 months after surgery were reported in the CC patients compared to healthy controls, as no differences were recorded at the 2-year follow-up.
In CC patients, the quality of their before the surgery was better than in healthy controls, while it decreased during the first year of follow-up compared to the interval before surgery.
Correa et al. [45] investigated the SF in CC survivors (n = 33) in comparison to a control group (n = 37) of women without a history of cancer using the FSFI test. SF decreased among the CC survivors, and 59.5% of women reported that the diagnosis and/or treatments of CC interfered with their sexuality. No differences were noticed with regard to sexual frequency in active women among the two groups. The mean scores of the cancer group were statistically inferior (p < 0.05) than those of the control group in all of the FSFI domains and in the total score. The mean total score in cancer survivors was 21.72. A FSFI score lower than 26 is indicative of sexual dysfunction. The authors reported that 64.9% of CC women reported vaginal stenosis or shortening; 59.5% were sexually inactive, and among those sexually active, 80% complained of sexual dysfunction.
Lee et al. [46] compared the QoL and SF in sexually active CC survivors (n = 104), with 45 months of median interval from diagnosis, and the healthy women group (n = 104). The authors did not record any statistical difference in SF between the two groups. It should be noted that, during the enrollment, 38.2% (91/238) of CC survivors and only 10.6% (28/265) in the control group were excluded due to the absence of sexual activity within 3 months.
Fifty-two patients who underwent surgery for early CC cancer were enrolled by Carter et al. [47] to assess their SF and QoL. Among these patients, 33 patients underwent radical trachelectomy, while 19 underwent RH. Both groups preoperatively demonstrated scores suggestive of depression and distress; FSFI were below the mean cut-off, highlighting a sexual dysfunction; however, the mean score increased from 16.79 preoperatively to 23.78 at 12 months and 22.20 at 24 months, with no significant difference between the groups.
In a Swedish study by Hofsjo et al. [48], 34 patients treated for CC with radiotherapy, either primary or in combination with surgery and/or chemotherapy, and 37 healthy age-matched control women scheduled for benign gynecological surgery were included. All subjects completed a questionnaire designed to assess sexual function in CC patients.
The women with cancer complained of worsening SF. The highest relative risk (RR) was reported for insufficient vaginal lubrication (RR 12.6), vaginal elasticity reduction (RR 6.5), reduced genital swelling when sexually aroused (RR 5.9), and the reduction of vaginal length during intercourse (RR 3.9). The frequency of orgasm was also lower in CC patients.
De Rosa et al. [49] investigated the role of ospemifene in CC survivors with vulvovaginal atrophy, focusing on their QoL and SF. Fifty-two patients were treated with ospemifene and were evaluated at baseline and after 6 months through the Vaginal Health Index (VHI), while the SF and QoL were measured by EORTC QLQ-CX24. After the treatment, each parameter of VHI significantly increased, primarily elasticity, fluid volume, epithelial integrity, moisture, and pH. In addition, SF was significantly improved, especially sexual activity, sexual vaginal functioning, body image, and sexual enjoyment. QoL partially changed at 6-month follow-up, and global health status and emotional and social functioning scores increased significantly, while general symptom scales did not change from the baseline data.
Plotti et al. [50] retrospectively evaluated QoL, urinary function, and SF in locally advanced CC patients previously who underwent neoadjuvant chemotherapy and RH type C2/type III and with at least 36 months of follow up. The authors administered the EORTC QLQ-CX24 Questionnaire, the EORT QLQ-C30, and the Incontinence Impact Questionnaire 7 to 90 patients. The global health status, referred to as the perception of well-being and QoL, was 71.72 (the score ranged from 0 to 100). CC survivors complained of gastrointestinal symptoms, mainly diarrhea (6% of patients) and constipation (75% of women). The results related to SF showed a good level of sexual enjoyment (75.6%), with a slight worsening of sexual activity. A total of 28% of women reported mild incontinence, although it was rarely disabling.
Bae et al. [51] reported a series of 137 CC patients. The authors assessed the SF by FSFI, depression by HAD S, and QoL by Functional Assessment of Cancer Therapy–General version 4 (FACT-G). They underlined that CC women reported sexual dysfunction (4.83 ± 4.16) and moderate to severe depression (11.08 ± 5.06) with a mean score of quality of life of 57.33 ± 8.47. The total score of SF ranges from 1.2 points to 36 points; higher scores imply higher SF. SF had a negative correlation with depression, while having a positive relationship with quality of life (p < 0.001) and physical well-being, social well-being, and functional well-being (p = 0.001). Instead, the correlation was not significative with psychological well-being (p = 0.223).
Serati et al. [52] compared SF in women who underwent RH with a control group of healthy women using the FSFI. They enrolled 38 patients treated for early CC and 35 controls. They also analyzed the possible impact of the surgical approach (n. 20 cases of laparoscopy vs. n. 18 cases of laparotomy) on SF. The FSFI score was significantly higher in the healthy controls compared to the cases. No significant differences were recorded between the laparoscopic and the laparotomic group (p = 0.30). In the laparoscopic group, 75% of women reported an impaired SF, 20% reported no change, and 5% reported an improvement post-RH; in the laparotomy group, the proportions were 55.5%, 33.4%, and 11.1%, respectively. In addition, at the time of FSFI administration, 14 (36.8%) women had not yet resumed sexual activity (8/20 (40%) in the laparoscopic group vs. 6/18 (33%) in the laparotomy group; p = 0.74).
A unique published randomized control study [53] analyzed a nurse-led positive psychology intervention on SF, depression, and subjective well-being amongst patients submitted to RH for early-stage CC. A total of 91 patients were enrolled in three tertiary hospitals in Chongqing, China, and were randomly allocated to the intervention (n = 46) or control group (usual care, n = 45). The intervention group received a 4-week PERMA model-based multidisciplinary team (leading nurses, specialist nurses, gynecologists, psychological counsellors, and rehabilitation physiotherapists) psychological intervention in addition to the usual care. The PERMA model is based on five independent elements: positive emotion (P), engagement (E), relationships (R), meaning (M), and accomplishment (A).
The authors analyzed the FSFI, the Self-rating Depression Scale, and the index of well-being to assess their aims at baseline and at 3 and 6 months after intervention. The SF was significantly improved in the intervention group (mean difference: −3.95, p = 0.005 at 3 months post-intervention; mean difference: −4.36, p = 0.001 at 6 months post-intervention), compared to the control group. In addition, the levels of depression and well-being in the intervention group were better in the intervention group (p < 0.05).
Cerentini et al. [54] tested the use of vaginal dilators in cervical cancer patients who underwent brachytherapy. However, the use of these tools did not increase the dimension of the vagina (length: p = 0.111, width: p = 0.484) within the first 3 months after the end of radiotherapy treatment.
Stanca et al. [55] used the standardized questionnaires (EORTC) to assesses the outcomes of QoL and SF after radical hysterectomy in CC. The survey showed a decrease of sexual function, activity, enjoyment, and an increase in sexual concern, together with menopausal symptoms.

3.3. Main Findings

All studies showed a general decrease of SF in patients with CC. However, the reasons for the increase in sexual dysfunction were different. The stage of the disease and the consequent therapeutic treatment were the two most important factors for sexual dysfunction. However, most studies had a sample with different cancer stages and with patients who underwent different treatments.
Several studies, such as those by Park, Stanca, Plotti, Bakker and Serati et al. [40,43,50,52,55] reported a significant worsening in patients who received both surgery and adjuvant therapy compared to surgery alone. In these studies, there was no difference between the surgery approaches. This aspect was also confirmed in the study by Carter [47], where there were no differences in SF in the patients who underwent radical trachelectomy or radical hysterectomy. This aspect was not observed in the Correa study [45], and this was likely due to the reduced number of women who underwent surgery. Aerts and Hofsjö et al. [44,45,46,47,48] reported sexual disfunction in CC patients who underwent surgery, but no difference if comparing the cancer group with the benign gynecological disease group. Serati et al. [55] did not report any benefit in CC patients between the laparoscopy and laparotomy approaches. Novackova and Jensen [39,41] showed no changes in sexual activity, enjoyment, or worry in patients who underwent surgery without adjuvant therapy. Bae et al. [51] showed that sexual dysfunction was related to a high level of depression. The scores of depression were higher for patients who underwent both types of chemoradiotherapy, althoughthere was no difference on the disease stage. Only Ljuca et al. [42] showed an improvement of vaginal function after adjuvant therapy; however, the survey consisted of a small number of patients. Plotti and Shi [50,51,52,53] suggested that SF improved over time in both the surgery and chemo or radio-therapy groups.

4. Discussion

Sexual dysfunction after CC treatment has a multifactorial aetiology which negatively affects the QoL. The most frequent causes of sexual dysfunction are psychological factors such as depression, loss of interest in sex, anxiety, and the presence of surgical scars that affect body self-image. Another important psychological factor is the fear of cancer recurrence that affects all aspects of life [56,57,58]. Furthermore, physical disorders such as asthenia, vaginal dryness, dyspareunia, and vaginal shortness are likely to occur after CC treatment, contributing to sexual distress (Table 2).
QoL encompasses several aspects of a person’s life in addition to a healthy sexual life, such as work activities, friendship, hobbies, and sport. The balance between all factors determines a healthy equilibrium, and therefore a positive spectrum of life quality. Conversely, factors negatively influencing the right balance can determine a chain reaction that contributes to a decrease in wellness. A cancer diagnosis and consequent surgical and/or medical treatments could be one of the most relevant destabilizing factors. Considering the CC characteristics and its development in the genital area, the impact on SF becomes more relevant, especially in young women with an active sexual life.
As previously mentioned, patients affected by CC can experience relevant changes in different aspects of life, such as the psychological state (such as anxiety and stress), body appearance, malnutrition (particularly during adjuvant therapy), relationship misunderstandings with their partner, and functional and anatomical problems. Undoubtedly, the impact of CC on QoL, as reported in the literature, could be different depending not only on the treatment adopted, whether surgical, medical, and/or radiation therapy but even by age, personal characteristics, and social aspects.
The surgical approach that is most adopted for CC treatment is the RH. The procedure consists of the resection of the parametrium and part of the vagina. The radicality of the surgery depends on the disease stage. This surgical approachis often associated with post-surgical complications, due to the radical nature of the surgery and neurological dysfunction. The nerves’ damage may cause: bladder function, intestinal dysfunction, vaginal shortness and dryness. The CC surgery could often be associated with chemotherapy and radiotherapy, which could enhance the genital dysfunction. All of these physical aspects associated with the psychological status could significantly interfere with SF and QoL.
The surgical approach could be endoscopic (laparoscopic or robotic) or laparotomic, depending on the different clinical and oncological aspects and the hospital’s internal guidelines.
Following the Laparoscopic Approach to Cervical Cancer (LACC) trial [59], the surgical approach to CC has been changed, and the current preference, especially for tumour size > 2 cm, is the laparotomic approach. In fact, this randomized trial, which compared minimally invasive surgery with laparotomy for CC treatment, demonstrated that the overall survival and disease-free survival of patients affected by CC undergoing laparotomy surgery is more effective compared to the endoscopic approach, even if the laparotomic approach was likely to interfere significantly with QoL and SF [60]. This aspect was confirmed in a study by Gueli Alletti et al. [61], demonstrating that that the body self-image and, consequently, QoL, decreases more rapidly and severely in cancer patients treated with laparotomy compared with a group of a patients treated with minimally invasive surgery (p = 0.004) (p = 0.002).
Several studies in the literature have evaluated the advantages of endoscopy both for benign pathology and oncology [62,63,64].
Minimally invasive surgical techniques employed on gynaecologic cancers, such as ovarian and endometrial cancer, have demonstrated advantages in improving surgical and aesthetic outcomes in selected cases [65,66,67], with promising results. The endoscopic approach is actually considered to be the gold standard for early-stage endometrial cancer treatment, and has several applications, even for ovarian cancer; however, this surgical approach is not always feasible for all oncological cases, especially for CC treatment after the LACC trial.
The limitation in the choice of surgical approach, based on the literature data, could contribute to a further increase in sexual dysfunction. Moreover, given the young average age of CC diagnosis and the impact of invasive treatments, the SF and QoL aspects need to acquire more relevance, and they should be considered in all phases of the treatment path, from counselling to follow-up [68,69].
Radiation therapy has an impact equivalent to surgery on SF, reducing the vaginal length and enhancing the vaginal dryness due to an actinic reaction.
The CC patients frequently undergo both surgery and radiation therapy, with the consequent reduction of the length and elasticity of the vagina. Even for patients submitted to exclusive chemo-radiation, the effects of brachytherapy are often superimposable.
As a consequence, for all these patients, sexual intercourse may be difficult and painful, and most of them are not able to achieve fulfilling sexual intercourse.
Recently, Beltran et al. [70] investigated the quality of life, sexual function, and satisfaction through the EORTC, FSFI and GRISS questionnaires, and compared the results to healthy women. This control studies reported a series of 66 patients analysed. The results showed a decrease of sexual function and quality of life (p < 0.05) in all questionnaires. This control study confirmed the negative impact that cervical cancer with medical therapy can have on women. However, a limit of the study was that the main treatment consisted of a combination of chemotherapy, radiotherapy, and brachytherapy, and did not include patients who underwent surgery. In fact, it is currently unclear whether the sexual dysfunction is attributable to surgical sequelae, chemo-radiotherapy, both, or all of these therapies.
Cancer survivors experience a loss of interest in sex and a consequent decrease in sexual activity, especially immediately after the treatment. In fact, the negative impact on the woman’s life is higher at the beginning of the treatment plan [71]. The most reassuring aspect, as reported by Carter J. et al. [72], is the fact that the time elapsed from treatment is a positive factor, and most patients report an improvement in SF.
All of these influencing factors are relevant, and it is important to know them in order to be able to attend to them promptly and effectively.
For these reasons, as confirmed in the study by Galicaa J. et al. [73], is important to follow and support CC patients with a multidisciplinary team (doctors, nurses, psychologists, and dieticians) before and after therapy. Women should be informed about possible vaginal changes and menopausal symptoms after treatments, in addition to the positive effects of psychological support, clinical nutrition, and physical activity on their life including SF [74,75]. The CC patients should be also counselled about the safe use of local estrogen therapy and systemic hormonal replacement therapy, when feasible, to improve their SF.
This type of tailored therapeutic approach should become a standard treatment, as the principal goal is not only to fight the pathology but also to achieve a good QoL for patients.
This article aims to give an overview of the latest findings related to QoL and SF in CC treatment. The most important limitation of this review is related to the heterogeneity of the available studies. The available studies present different designs and a significant heterogeneity of patients who underwent different treatments. Moreover, the studies were conducted during different periods, from 2003 to 2022, and the treatments adopted are not sufficiently comparable due to the evolution of therapeutic strategies over time. Finally, the most significant shortcoming is the fact that most of the studies had a small number of patients, and the tests used are different and not always comparable. It is clear from all studies that CC has an impact on Qol and SF, but it is unclear whether it is more related to a psychological condition or to a consequence of medical or surgical treatments. Prospective studies using standardised questionnaires are needed to reach definitive conclusions.
The current study, however, despite the limitations previously reported, did result in some important findings. The impact of medical (chemoradiation therapy) vs. surgical treatment on SF remains controversial because the studies reported different conclusions (Table 1).
Some authors have suggested that there are no significant differences in SF and QoL depending on the surgical approach, and that most CC cancer patients report an improvement of SF and the disappearance of vaginal problems over time. However, based on the results of most studies, the combined approach of surgery and radiotherapy seems to have the most negative impact on SF [76].
A key aspect remains that, after CC diagnosis, both patients and their families and care professionals should focus not only on treating cancer, but must not forget that an adequate quality of life must be maintained.
In this field, the personalisation of cancer treatment is essential, and must take into account such factors as age, social status, and expectations. Furthermore, it is important to provide psychological and psychophysical support, not only during treatment but also afterwards. Moreover, several studies have proven the importance of different types of support, in addition to psychotherapy including: exercise, yoga, and biofeedback [77,78,79,80,81].
Over the years, thanks to technological innovations, surgical and medical treatment approaches have reduced their physical impact, while maintaining the same levels of efficiency. Although this is an important point, it cannot be considered sufficient to overcome the entire impact on the QoL and SF of cancer patients, which can only be achieved with constant support. It is relevant that sexual disfunction after CC treatment tends to improve over time [82,83]. Evidence from studies of other gynaecological malignancies has confirmed these findings, reporting that sexual function improves with increasing time since the cancer diagnosis [84,85]. The importance of the SF of cancer patients is still not sufficiently considered by the majority of care professionals, who forget to investigate and treat it appropriately during cancer treatment and follow-ups. Women with CC are often young, and the absence of a satisfactory sex life can affect their personal life and relationships, with severe consequences to their QoL.
Indeed, it is important to understand that the psychological aspects related to cancer treatment and the consequent impact on QoL and SF are related to several factors that might be different in patients, such as age, social status, work, geographical area, religion, etc. Consequently, it is crucial to adapt the treatment according to the patient’s characteristics. A relatively new factor that should be taken into account is cancer prevention and screening. Even though screening programmes and cancer prevention strategies are still relatively ineffective for most cancer diseases, CC has a great potential for reduction through prevention and early detection. This should publicised more widely, as it seems to be the key strategy in terms of fighting CC.
In 99% of cases, CC is caused by HPV infection [86,87,88], as demonstrated by studies focused on countries such as Australia and Rwanda. A screening program is the best strategy to decrease CC incidence in the short term, and HPV vaccination programs represent the best strategy to eradicate CC in the long term [89,90,91,92,93]. According to the World Health Organization (WHO), the primary goal must remain the eradication of CC through the strengthening of vaccination and screening programmes. However, due to a heterogeneous adherence to HPV vaccination and Pap-testing in different countries, it remains a difficult goal to achieve [94,95,96]. The sensible reduction of QoL and SF after CC treatments will continue to be an issue in the coming years. Therefore, new randomized clinical trials are needed in order to investigate which treatment option may be the most effective for the management of vaginal symptoms related to CC treatment. Several studies have shown the benefit that hormonal therapies such as CO2 laser therapy, hyaluronic acid, and vaginal dilators may have on the improvement of vaginal symptoms [97,98,99,100,101,102,103,104,105,106]. Although there are no trials with large series’ that compare all of these therapies in patients with CC, it is considered essential, in alignment with the WHO goal on the elimination of HPV-related CC, to also focus therapeutic research on the improvement of QoL and vaginal symptoms that would help all women after treatment. Therefore, further studies are needed to clarify the factors contributing to the decrease in SF and QoL in CC.

5. Conclusions

This study aimed to furnish a complete overview of QoL and SF aspects in CC patients. As previously reported, the available literature presents some discrepancies in terms of the heterogeneity of studies, the small number of cases, and the use of different questionnaires; thus, even the different study results are not always in accordance, making it impossible to reach definitive conclusions.
However, despite the limitations, it was possible to reach certain conclusions:
First of all, the evidence confirms the importance of a multidisciplinary approach for CC patients, which should focus, in a first phase, on understanding the patient’s characteristics and expectations, with the aim of tailoring the best treatment options for them. The second phase should be aimed at offering patients the best psychological support, with the goal of understanding their needs and preventing them from feeling alone in their fight against cancer. This phase should even be supported by a balanced diet and physical activities, which are an integral part of oncological and psychological therapies.
Psychological support remains crucially important for all oncologic patients. Several studies have demonstrated that psychological support has a positive impact on treatment adherence and oncologic outcomes [107,108].
Third, the therapeutic approach should be tailored not only based on pathology, but also on patient characteristics and expectations, because, as demonstrated in some studies [109,110], some strategies could have a more significant impact than others, and this should always be considered. Patients should always be involved in the decision process when choosing the therapeutic approach during counselling, and they should be guided through the process of considering the advantages and disadvantages of a particular therapy.
Fourth, it is necessary to conduct prospective studies with validated questionnaires in the near future in order to evaluate the impact and possible benefits on SF and QoL of different treatments. These studies should investigate all possible factors involved in potential changes of SF. Several investigations should be conducted on surgical techniques and approaches (such as laparoscopy, laparotomy, and robotic) and the impact of different treatment modalities (surgery, radiation therapy, and chemotherapy) on sexual function.
Future perspectives on CC treatment, including the improvement of QoL and SF, should be directed towards overcoming the pathology through cancer prevention, with the aim of eradicating a disease that has a significant oncological and social impact and often affects young patients.

Author Contributions

Conceptualization: M.T. and S.C. and S.G.A.; Methodology: V.A.C. and C.M.; Software: M.A.; Validation: A.E. and M.P.; Formal Analysis: G.V.; Investigation: M.L.V. and F.G.; Resources: V.P. and M.T. and M.A.; Data curation: S.C. and G.C. and M.T.; Writin original draft preparation: C.C. and S.R.; Writing review and editing: S.C. and M.T. and M.A.; Visualization: S.G.A. and V.A.C.; Project administration: S.C. and M.T. and S.G.A.; Supervision: M.P. and A.E. All authors have read and agreed to the published version of the manuscript.

Funding

This research received no external funding.

Data Availability Statement

Not applicable.

Conflicts of Interest

The authors declare no conflict of interest.

References

  1. Lin, S.; Gao, K.; Gu, S.; You, L.; Qian, S.; Tang, M.; Wang, J.; Chen, K.; Jin, M. Worldwide trends in cervical cancer incidence and mortality, with predictions for the next 15 years. Cancer 2021, 127, 4030–4039. [Google Scholar] [CrossRef] [PubMed]
  2. Momenimovahed, Z.; Mazidimoradi, A.; Maroofi, P.; Allahqoli, L.; Salehiniya, H.; Alkatout, I. Global, regional and national burden, incidence, and mortality of cervical cancer. Cancer Rep. 2022, 6, e1756. [Google Scholar] [CrossRef] [PubMed]
  3. Arbyn, M.; Weiderpass, E.; Bruni, L.; de Sanjosé, S.; Saraiya, M.; Ferlay, J.; Bray, F. Estimates of incidence and mortality of cervical cancer in 2018: A world-wide analysis. Lancet Glob. Health 2020, 8, e191–e203. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  4. Bhatla, N.; Aoki, D.; Sharma, D.N.; Sankaranarayanan, R. Cancer of the cervix uteri. Int. J. Gynecol. Obstet. 2018, 143, 22–36. [Google Scholar] [CrossRef] [PubMed]
  5. Vaccarella, S.; Laversanne, M.; Ferlay, J.; Bray, F. Cervical cancer in Africa, Latin America and the Caribbean and Asia: Regional inequalities and changing trends. Int. J. Cancer 2017, 141, 1997–2001. [Google Scholar] [CrossRef] [Green Version]
  6. Rossi, P.G.; Caroli, S.; Mancini, S.; Bianchi, P.S.D.; Finarelli, A.C.; Naldoni, C.; Bucchi, L.; Falcini, F.; Emilia-Romagna Cervical Cancer Screening and Pathology Registry Group. Screening history of cervical cancers in Emilia-Romagna, Italy: Defining priorities to improve cervical cancer screening. Eur. J. Cancer Prev. 2015, 24, 128–134. [Google Scholar] [CrossRef]
  7. Zucchetto, A.; Ronco, G.; Rossi, P.G.; Zappa, M.; Ferretti, S.; Franzo, A.; Falcini, F.; Visioli, C.B.; Zanetti, R.; Biavati, P.; et al. Screening patterns within organized programs and survival of Italian women with invasive cervical cancer. Prev. Med. 2013, 57, 220–226. [Google Scholar] [CrossRef]
  8. Serraino, D.; Gini, A.; Taborelli, M.; Ronco, G.; Rossi, P.G.; Zappa, M.; Crocetti, E.; Franzo, A.; Falcini, F.; Visioli, C.B.; et al. Changes in cervical cancer incidence following the introduction of organized screening in Italy. Prev. Med. 2015, 75, 56–63. [Google Scholar] [CrossRef]
  9. Vaccarella, S.; Lortet-Tieulent, J.; Plummer, M.; Franceschi, S.; Bray, F. Worldwide trends in cervical cancer incidence: Impact of screening against changes in disease risk factors. Eur. J. Cancer 2013, 49, 3262–3273. [Google Scholar] [CrossRef]
  10. Sasieni, P.; Castanon, A.; Cuzick, J. Effectiveness of cervical screening with age: Population based case-control study of prospectively recorded data. BMJ 2009, 339, b2968. [Google Scholar] [CrossRef] [Green Version]
  11. Arbyn, M.; Gultekin, M.; Morice, P.; Nieminen, P.; Cruickshank, M.; Poortmans, P.; Kelly, D.; Poljak, M.; Bergeron, C.; Ritchie, D.; et al. The European response to the WHO call to eliminate cervical cancer as a public health problem. Int. J. Cancer 2020, 148, 277–284. [Google Scholar] [CrossRef] [PubMed]
  12. Gultekin, M.; Ramirez, P.T.; Broutet, N.; Hutubessy, R. World Health Organization call for action to eliminate cervical cancer globally. Int. J. Gynecol. Cancer 2020, 30, 426–427. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  13. Gultekin, M.; Morice, P.; Concin, N.; Querleu, D. ESGO contribution to the WHO initiative on elimination of cervical cancer. Int. J. Gynecol. Cancer 2020, 30, 434–435. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  14. Karimi-Zarchi, M.; Allahqoli, L.; Nehmati, A.; Kashi, A.M.; Taghipour-Zahir, S.; Alkatout, I. Can the prophylactic quadrivalent HPV vaccine be used as a therapeutic agent in women with CIN? A randomized trial. BMC Public Health 2020, 20, 274. [Google Scholar] [CrossRef]
  15. Kyrgiou, M.; Arbyn, M.; Bergeron, C.; Bosch, F.X.; Dillner, J.; Jit, M.; Kim, J.; Poljak, M.; Nieminen, P.; Sasieni, P.; et al. Cervical screening: ESGO-EFC position paper of the European Society of Gynaecologic Oncology (ESGO) and the European Federation of Colposcopy (EFC). Br. J. Cancer 2020, 123, 510–517. [Google Scholar] [CrossRef]
  16. Chrysostomou, A.C.; Stylianou, D.C.; Constantinidou, A.; Kostrikis, L.G. Cervical Cancer Screening Programs in Europe: The Transition Towards HPV Vaccination and Population-Based HPV Testing. Viruses 2018, 10, 729. [Google Scholar] [CrossRef] [Green Version]
  17. Venturelli, F.; Baldacchini, F.; Campari, C.; Perilli, C.; Pascucci, M.G.; Finarelli, A.C.; Moscara, L.; Rossi, P.G. Association between mothers’ screening uptake and daughters’ HPV vaccination: A quasi-experimental study on the effect of an active invitation campaign. BMJ Open 2017, 7, e016189. [Google Scholar] [CrossRef] [Green Version]
  18. Malagón, T.; Drolet, M.; Boily, M.-C.; Laprise, J.-F.; Brisson, M. Changing Inequalities in Cervical Cancer: Modeling the Impact of Vaccine Uptake, Vaccine Herd Effects, and Cervical Cancer Screening in the Post-Vaccination Era. Cancer Epidemiol. Biomark. Prev. 2015, 24, 276–285. [Google Scholar] [CrossRef] [Green Version]
  19. Bos, A.B.; Rebolj, M.; Habbema, J.D.F.; van Ballegooijen, M. Nonattendance is still the main limitation for the effectiveness of screening for cervical cancer in the Netherlands. Int. J. Cancer 2006, 119, 2372–2375. [Google Scholar] [CrossRef]
  20. Andrae, B.; Kemetli, L.; Sparén, P.; Silfverdal, L.; Strander, B.; Ryd, W.; Dillner, J.; Törnberg, S. Screening-Preventable Cervical Cancer Risks: Evidence from a Nationwide Audit in Sweden. Gynecol. Oncol. 2008, 100, 622–629. [Google Scholar] [CrossRef] [Green Version]
  21. Rossi, P.G.; Baldacchini, F.; Ronco, G. The Possible Effects on Socio-Economic Inequalities of Introducing HPV Testing as Primary Test in Cervical Cancer Screening Programs. Front. Oncol. 2014, 4, 20. [Google Scholar] [CrossRef] [Green Version]
  22. Drolet, M.; Bénard, É.; Pérez, N.; Brisson, M.; HPV Vaccination Impact Study Group. Population-level impact and herd effects following the introduction of human papillomavirus vaccination programmes: Updated systematic review and meta-analysis. Lancet 2019, 394, 497–509. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  23. Cameron, R.L.; Kavanagh, K.; Pan, J.; Love, J.; Cuschieri, K.; Robertson, C.; Ahmed, S.; Palmer, T.; Pollock, K.G. Human Papillomavirus Prevalence and Herd Immunity after Introduction of Vaccination Program, Scotland, 2009–2013. Emerg. Infect. Dis. 2016, 22, 56–64. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  24. Koh, W.J.; Abu-Rustum, N.R.; Bean, S. NCCN guidelines version 5.2019 in cervical cancer. J. Natl. Compr. Cancer Netw. 2019, 17, 64–84. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  25. Zullo, M.A.; Manci, N.; Angioli, R.; Muzii, L.; Panici, P.B. Vesical dysfunctions after radical hysterectomy for cervical cancer: A critical review. Crit. Rev. Oncol. 2003, 48, 287–293. [Google Scholar] [CrossRef] [PubMed]
  26. Sakuragi, N.; Murakami, G.; Konno, Y.; Kaneuchi, M.; Watari, H. Nerve-sparing radical hysterectomy in the precision surgery for cervical cancer. J. Gynecol. Oncol. 2020, 31, e49. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  27. Querleu, D.; Morrow, C.P. Classification of radical hysterectomy. Lancet Oncol. 2008, 9, 297–303. [Google Scholar] [CrossRef]
  28. Stabile, C.; Goldfarb, S.; Baser, R.E.; Goldfrank, D.J.; Abu-Rustum, N.R.; Barakat, R.R.; Dickler, M.N.; Carter, J. Sexual health needs and educational intervention preferences for women with cancer. Breast Cancer Res. Treat. 2017, 165, 77–84. [Google Scholar] [CrossRef]
  29. Bober, S.L.; Reese, J.B.; Barbera, L.; Bradford, A.; Carpenter, K.M.; Goldfarb, S.; Carter, J. How to ask and what to do: A guide for clinical inquiry and intervention regarding female sexual health after cancer. Curr. Opin. Support. Palliat. Care 2016, 10, 44–54. [Google Scholar] [CrossRef] [Green Version]
  30. Vitale, S.G.; Caruso, S.; Rapisarda, A.M.C.; Cianci, S.; Cianci, A. Isoflavones, calcium, vitamin D and inulin improve quality of life, sexual function, body composition and metabolic parameters in menopausal women: Result from a prospective, randomized, placebo-controlled, parallel-group study. Menopausal Rev. 2018, 17, 32–38. [Google Scholar] [CrossRef] [Green Version]
  31. Caruso, S.; Cianci, S.; Fava, V.; Rapisarda, A.M.C.; Cutello, S.; Cianci, A. Vaginal health of postmenopausal women on nutraceutical containing equol. Menopause 2018, 25, 430–435. [Google Scholar] [CrossRef] [PubMed]
  32. Caruso, S.; Cianci, S.; Cariola, M.; Fava, V.; Rapisarda, A.M.; Cianci, A. Effects of nutraceuticals on quality of life and sexual function of perimenopausal women. J. Endocrinol. Investig. 2017, 40, 27–32, Erratum in: J. Endocrinol. Investig. 2017, 40, 339; Erratum in: J. Endocrinol. Investig. 2017, 40, 341. [Google Scholar] [CrossRef] [PubMed]
  33. Caruso, S.; Rapisarda, A.M.; Cianci, S. Sexuality in menopausal women. Curr. Opin. Psychiatry 2016, 29, 323–330. [Google Scholar] [CrossRef]
  34. Caruso, S.; Cianci, A.; Sarpietro, G.; Matarazzo, M.G.; Panella, M.; Cianci, S. Ultralow 0.03 mg vaginal estriol in postmenopausal women who underwent surgical treatment for stress urinary incontinence: Effects on quality of life and sexual function. Menopause 2019, 27, 162–169. [Google Scholar] [CrossRef]
  35. Ye, S.; Yang, J.; Cao, D.; Lang, J.; Shen, K. A Systematic Review of Quality of Life and Sexual Function of Patients With Cervical Cancer After Treatment. Int. J. Gynecol. Cancer 2014, 24, 1146–1157. [Google Scholar] [CrossRef]
  36. Vistad, I.; Fosså, S.D.; Dahl, A.A. A critical review of patient-rated quality of life studies of long-term survivors of cervical cancer. Gynecol. Oncol. 2006, 102, 563–572. [Google Scholar] [CrossRef] [PubMed]
  37. Tramacere, F.; Lancellotta, V.; Casà, C.; Fionda, B.; Cornacchione, P.; Mazzarella, C.; De Vincenzo, R.P.; Macchia, G.; Ferioli, M.; Rovirosa, A.; et al. Assessment of Sexual Dysfunction in Cervical Cancer Patients after Different Treatment Modality: A Systematic Review. Medicina 2022, 58, 1223. [Google Scholar] [CrossRef]
  38. Kirchheiner, K.; Smet, S.; Jürgenliemk-Schulz, I.M.; Haie-Meder, C.; Chargari, C.; Lindegaard, J.C.; Fokdal, L.U.; Spampinato, S.; Schmid, M.P.; Sturdza, A.; et al. Impact of Vaginal Symptoms and Hormonal Replacement Therapy on Sexual Outcomes After Definitive Chemoradiotherapy in Patients With Locally Advanced Cervical Cancer: Results from the EMBRACE-I Study. Int. J. Radiat. Oncol. 2021, 112, 400–413. [Google Scholar] [CrossRef]
  39. Novackova, M.; Pastor, Z.; Chmel, R.; Mala, I. Sexuality and quality of life after nerve-sparing radical hysterectomy for cervical cancer: A prospective study. Taiwan J. Obstet. Gynecol. 2022, 61, 641–645. [Google Scholar] [CrossRef]
  40. Park, S.Y.; Bae, D.-S.; Nam, J.H.; Park, C.T.; Cho, C.-H.; Lee, J.M.; Lee, M.K.; Kim, S.H.; Yun, Y.H. Quality of life and sexual problems in disease-free survivors of cervical cancer compared with the general population. Cancer 2007, 110, 2716–2725. [Google Scholar] [CrossRef] [Green Version]
  41. Jensen, P.T.; Groenvold, M.; Klee, M.C.; Thranov, I.; Petersen, M.A.; Machin, D. Early-stage cervical carcinoma, radical hysterectomy, and sexual function. A longitudinal study. Cancer 2004, 100, 97–106. [Google Scholar] [CrossRef] [PubMed]
  42. Ljuca, D.; Marošević, G. Impact of chemoradiotherapy on vaginal and sexual function of patients with FIGO IIb cervical cancer. Bosn. J. Basic Med. Sci. 2011, 11, 62–64. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  43. Bakker, R.; Kenter, G.; Creutzberg, C.; Stiggelbout, A.; Derks, M.; Mingelen, W.; Kroon, C.; Vermeer, W.; Ter Kuile, M. Sexual distress and associated factors among cervical cancer survivors: A cross-sectional multicenter observational study. Psychooncology 2016, 26, 1470–1477. [Google Scholar] [CrossRef] [PubMed]
  44. Aerts, L.; Enzlin, P.; Verhaeghe, J.; Poppe, W.; Vergote, I.; Amant, F. Long-Term Sexual Functioning in Women After Surgical Treatment of Cervical Cancer Stages IA to IB: A Prospective Controlled Study. Int. J. Gynecol. Cancer 2014, 24, 1527–1534. [Google Scholar] [CrossRef] [PubMed]
  45. Corrêa, C.S.L.; Leite, I.C.G.; Andrade, A.P.S.; Ferreira, A.D.S.S.; Carvalho, S.M.; Guerra, M.R. Sexual function of women surviving cervical cancer. Arch. Gynecol. Obstet. 2015, 293, 1053–1063. [Google Scholar] [CrossRef] [PubMed]
  46. Lee, Y.; Lim, M.C.; Kim, S.I.; Joo, J.; Lee, D.O.; Park, S.-Y. Comparison of Quality of Life and Sexuality between Cervical Cancer Survivors and Healthy Women. Cancer Res. Treat. 2016, 48, 1321–1329. [Google Scholar] [CrossRef] [Green Version]
  47. Carter, J.; Sonoda, Y.; Baser, R.E.; Raviv, L.; Chi, D.S.; Barakat, R.R.; Iasonos, A.; Brown, C.L.; Abu-Rustum, N.R. A 2-year prospective study assessing the emotional, sexual, and quality of life concerns of women undergoing radical trachelectomy versus radical hysterectomy for treatment of early-stage cervical cancer. Gynecol. Oncol. 2010, 119, 358–365. [Google Scholar] [CrossRef] [Green Version]
  48. Hofsjö, A.; Bergmark, K.; Blomgren, B.; Jahren, H.; Bohm-Starke, N. Radiotherapy for cervical cancer—Impact on the vaginal epithelium and sexual function. Acta Oncol. 2017, 57, 338–345. [Google Scholar] [CrossRef] [Green Version]
  49. De Rosa, N.; Lavitola, G.; Giampaolino, P.; Morra, I.; Nappi, C.; Bifulco, G. Impact of Ospemifene on Quality of Life and Sexual Function in Young Survivors of Cervical Cancer: A Prospective Study. BioMed Res. Int. 2017, 2017, 7513610. [Google Scholar] [CrossRef] [Green Version]
  50. Plotti, F.; Terranova, C.; Capriglione, S.; Crispino, S.; Pomi, A.L.; Nardone, C.D.C.; Montera, R.; Panici, P.B.; Angioli, R.; Scaletta, G. Assessment of Quality of Life and Urinary and Sexual Function After Radical Hysterectomy in Long-Term Cervical Cancer Survivors. Int. J. Gynecol. Cancer 2018, 28, 818–823. [Google Scholar] [CrossRef]
  51. Bae, H.; Park, H. Sexual function, depression, and quality of life in patients with cervical cancer. Support. Care Cancer 2015, 24, 1277–1283. [Google Scholar] [CrossRef] [PubMed]
  52. Serati, M.; Salvatore, S.; Uccella, S.; Laterza, R.M.; Cromi, A.; Ghezzi, F.; Bolis, P. Sexual function after radical hysterectomy for early-stage cervical cancer: Is there a difference between laparoscopy and laparotomy? J. Sex. Med. 2009, 6, 2516–2522. [Google Scholar] [CrossRef]
  53. Shi, Y.; Cai, J.; Wu, Z.; Jiang, L.; Xiong, G.; Gan, X.; Wang, X. Effects of a nurse-led positive psychology intervention on sexual function, depression and subjective well-being in postoperative patients with early-stage cervical cancer: A randomized controlled trial. Int. J. Nurs. Stud. 2020, 111, 103768. [Google Scholar] [CrossRef] [PubMed]
  54. Cerentini, T.M.; Schlöttgen, J.; Viana da Rosa, P.; La Rosa, V.L.; Vitale, S.G.; Giampaolino, P.; Valenti, G.; Cianci, S.; Macagnan, F.E. Clinical and Psychological Outcomes of the Use of Vaginal Dilators After Gynaecological Brachytherapy: A Randomized Clinical Trial. Adv. Ther. 2019, 36, 1936–1949. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  55. Stanca, M.; Căpîlna, D.M.; Trâmbițaș, C.; Căpîlna, M.E. The Overall Quality of Life and Oncological Outcomes Following Radical Hysterectomy in Cervical Cancer Survivors Results from a Large Long-Term Single-Institution Study. Cancers 2022, 14, 317. [Google Scholar] [CrossRef] [PubMed]
  56. Hanprasertpong, J.; Geater, A.; Jiamset, I.; Padungkul, L.; Hirunkajonpan, P.; Songhong, N. Fear of cancer recurrence and its predictors among cervical cancer survivors. J. Gynecol. Oncol. 2017, 28, e72. [Google Scholar] [CrossRef] [Green Version]
  57. Karawekpanyawong, N.; Kaewkitikul, K.; Maneeton, B.; Maneeton, N.; Siriaree, S. The prevalence of depressive disorder and its association in Thai cervical cancer patients. PLoS ONE 2021, 16, e0252779. [Google Scholar] [CrossRef]
  58. Cull, A.; Cowie, V.; Farquharson, D.; Livingstone, J.; Smart, G.; Elton, R. Early stage cervical cancer: Psychosocial and sexual outcomes of treatment. Br. J. Cancer 1993, 68, 1216–1220. [Google Scholar] [CrossRef] [Green Version]
  59. Ramirez, P.T.; Frumovitz, M.; Pareja, R.; Lopez, A.; Vieira, M.; Ribeiro, M.; Buda, A.; Yan, X.; Shuzhong, Y.; Chetty, N.; et al. Minimally Invasive versus Abdominal Radical Hysterectomy for Cervical Cancer. N. Engl. J. Med. 2018, 379, 1895–1904. [Google Scholar] [CrossRef]
  60. Uccella, S.; Capozzi, V.A.; Ricco’, M.; Perrone, E.; Zanello, M.; Ferrari, S.; Zorzato, P.C.; Seracchioli, R.; Cromi, A.; Serati, M.; et al. Sexual Function following Laparoscopic versus Transvaginal Closure of the Vaginal Vault after Laparoscopic Hysterectomy: Secondary Analysis of a Randomized Trial by the Italian Society of Gynecological Endoscopy Using a Validated Questionnaire. J. Minim. Invasive Gynecol. 2019, 27, 186–194. [Google Scholar] [CrossRef]
  61. Alletti, S.G.; Vizzielli, G.; Lafuenti, L.; Costantini, B.; Fagotti, A.; Fedele, C.; Cianci, S.; Perrone, E.; Gallotta, V.; Rossitto, C.; et al. Single-Institution Propensity-Matched Study to Evaluate the Psychological Effect of Minimally Invasive Interval Debulking Surgery Versus Standard Laparotomic Treatment: From Body to Mind and Back. J. Minim. Invasive Gynecol. 2018, 25, 816–822. [Google Scholar] [CrossRef] [PubMed]
  62. Alletti, S.G.; Perrone, E.; Cretì, A.; Cianci, S.; Uccella, S.; Fedele, C.; Fanfani, F.; Palmieri, S.; Fagotti, A.; Scambia, G.; et al. Feasibility and perioperative outcomes of percutaneous-assisted laparoscopic hysterectomy: A multicentric Italian experience. Eur. J. Obstet. Gynecol. Reprod. Biol. 2019, 245, 181–185. [Google Scholar] [CrossRef] [PubMed]
  63. Cianci, S.; Rosati, A.; Rumolo, V.; Alletti, S.G.; Gallotta, V.; Turco, L.C.; Corrado, G.; Vizzielli, G.; Fagotti, A.; Fanfani, F.; et al. Robotic Single-Port Platform in General, Urologic, and Gynecologic Surgeries: A Systematic Review of the Literature and Meta-analysis. World J. Surg. 2019, 43, 2401–2419. [Google Scholar] [CrossRef] [PubMed]
  64. Alletti, S.G.; Cianci, S.; Perrone, E.; Fanfani, F.; Vascone, C.; Uccella, S.; Gallotta, V.; Vizzielli, G.; Fagotti, A.; Monterossi, G.; et al. Technological innovation and personalized surgical treatment for early-stage endometrial cancer patients: A prospective multicenter Italian experience to evaluate the novel percutaneous approach. Eur. J. Obstet. Gynecol. Reprod. Biol. 2019, 234, 218–222. [Google Scholar] [CrossRef]
  65. Cianci, S.; Rosati, A.; Vargiu, V.; Capozzi, V.A.; Sozzi, G.; Gioè, A.; Alletti, S.G.; Ercoli, A.; Cosentino, F.; Berretta, R.; et al. Sentinel Lymph Node in Aged Endometrial Cancer Patients “The SAGE Study”: A Multicenter Experience. Front. Oncol. 2021, 11, 737096. [Google Scholar] [CrossRef]
  66. Capozzi, V.A.; Riemma, G.; Rosati, A.; Vargiu, V.; Granese, R.; Ercoli, A.; Cianci, S. Surgical complications occurring during minimally invasive sentinel lymph node detection in endometrial cancer patients. A systematic review of the literature and metanalysis. Eur. J. Surg. Oncol. (EJSO) 2021, 47, 2142–2149. [Google Scholar] [CrossRef]
  67. Cianci, S.; Perrone, E.; Rossitto, C.; Fanfani, F.; Tropea, A.; Biondi, A.; Scambia, G.; Alletti, S.G. Percutaneous-assisted vs mini-laparoscopic hysterectomy: Comparison of ultra-minimally invasive approaches. Updates Surg. 2020, 73, 2347–2354. [Google Scholar] [CrossRef]
  68. Uccella, S.; Franchi, M.P.; Cianci, S.; Zorzato, P.C.; Bertoli, F.; Alletti, S.G.; Ghezzi, F.; Scambia, G. Laparotomy vs. minimally invasive surgery for ovarian cancer recurrence: A systematic review. Gland Surg. 2020, 9, 1130–1139. [Google Scholar] [CrossRef]
  69. Gueli Alletti, S.; Capozzi, V.A.; Rosati, A.; De Blasis, I.; Cianci, S.; Vizzielli, G.; Uccella, S.; Gallotta, V.; Fanfani, F.; Fagotti, A.; et al. Laparoscopy vs. laparotomy for advanced ovarian cancer: A systematic review of the literature. Minerva Med. 2019, 110, 341–357. [Google Scholar] [CrossRef]
  70. Membrilla-Beltran, L.; Cardona, D.; Camara-Roca, L.; Aparicio-Mota, A.; Roman, P.; Rueda-Ruzafa, L. Impact of Cervical Cancer on Quality of Life and Sexuality in Female Survivors. Int. J. Environ. Res. Public Health 2023, 20, 3751. [Google Scholar] [CrossRef]
  71. Bergmark, K.; Åvall-Lundqvist, E.; Dickman, P.W.; Henningsohn, L.; Steineck, G. Vaginal Changes and Sexuality in Women with a History of Cervical Cancer. N. Engl. J. Med. 1999, 340, 1383–1389. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  72. Carter, J.; Raviv, L.; Applegarth, L.; Ford, J.S.; Josephs, L.; Grill, E.; Sklar, C.; Sonoda, Y.; Baser, R.E.; Barakat, R.R. A cross-sectional study of the psychosexual impact of cancer-related infertility in women: Third-party reproductive assistance. J. Cancer Surviv. 2010, 4, 236–246. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  73. Galica, J.; Saunders, S.; Romkey-Sinasac, C.; Silva, A.; Ethier, J.-L.; Giroux, J.; Jull, J.; Maheu, C.; Ross-White, A.; Stark, D.; et al. The needs of gynecological cancer survivors at the end of primary treatment: A scoping review and proposed model to guide clinical discussions. Patient Educ. Couns. 2022, 105, 1761–1782. [Google Scholar] [CrossRef] [PubMed]
  74. Cianci, S.; Rumolo, V.; Rosati, A.; Scaletta, G.; Alletti, S.G.; Cerentini, T.M.; Sleiman, Z.; Lordelo, P.; Angerame, D.; Garganese, G.; et al. Sarcopenia in Ovarian Cancer Patients, Oncologic Outcomes Revealing the Importance of Clinical Nutrition: Review of Literature. Curr. Pharm. Des. 2019, 25, 2480–2490. [Google Scholar] [CrossRef] [PubMed]
  75. Plotti, F.; Terranova, C.; Luvero, D.; Bartolone, M.; Messina, G.; Feole, L.; Cianci, S.; Scaletta, G.; Marchetti, C.; Di Donato, V.; et al. Diet and Chemotherapy: The Effects of Fasting and Ketogenic Diet on Cancer Treatment. Chemotherapy 2020, 65, 77–84. [Google Scholar] [CrossRef] [PubMed]
  76. Lammerink, E.A.; de Bock, G.H.; Pras, E.; Reyners, A.K.; Mourits, M.J. Sexual functioning of cervical cancer survivors: A review with a female perspective. Maturitas 2012, 72, 296–304. [Google Scholar] [CrossRef]
  77. Lundt, A.; Jentschke, E. Long-Term Changes of Symptoms of Anxiety, Depression, and Fatigue in Cancer Patients 6 Months After the End of Yoga Therapy. Integr. Cancer Ther. 2019, 18, 1534735418822096. [Google Scholar] [CrossRef] [Green Version]
  78. Taso, C.-J.; Lin, H.-S.; Lin, W.-L.; Chen, S.-M.; Huang, W.-T.; Chen, S.-W. The effect of yoga exercise on improving depression, anxiety, and fatigue in women with breast cancer: A randomized controlled trial. J. Nurs. Res. 2014, 22, 155–164. [Google Scholar] [CrossRef] [Green Version]
  79. Sacomori, C.; Lorca, L.A.; Martinez-Mardones, M.; Salas-Ocaranza, R.I.; Reyes-Reyes, G.P.; Pizarro-Hinojosa, M.N.; Plasser-Troncoso, J. A randomized clinical trial to assess the effectiveness of pre- and post-surgical pelvic floor physiotherapy for bowel symptoms, pelvic floor function, and quality of life of patients with rectal cancer: CARRET protocol. Trials 2021, 22, 448. [Google Scholar] [CrossRef]
  80. Alcântara-Silva, T.R.; De Freitas-Junior, R.; Freitas, N.M.A.; Junior, W.D.P.; Da Silva, D.J.; Machado, G.D.P.; Ribeiro, M.K.A.; Carneiro, J.P.; Soares, L. Music Therapy Reduces Radiotherapy-Induced Fatigue in Patients With Breast or Gynecological Cancer: A Randomized Trial. Integr. Cancer Ther. 2018, 17, 628–635. [Google Scholar] [CrossRef] [Green Version]
  81. Burish, T.G.; Jenkins, R.A. Effectiveness of biofeedback and relaxation training in reducing the side effects of cancer chemotherapy. Health Psychol. 1992, 11, 17–23. [Google Scholar] [CrossRef]
  82. Greimel, E.R.; Winter, R.; Kapp, K.S.; Haas, J. Quality of life and sexual functioning after cervical cancer treatment: A long-term follow-up study. Psycho-Oncol. J. Psychol. Soc. Behav. Dimens. Cancer 2009, 18, 476–482. [Google Scholar] [CrossRef]
  83. Flay, L.D.; Matthews, J.H. The effects of radiotherapy and surgery on the sexual function of women treated for cervical cancer. Int. J. Radiat. Oncol. 1995, 31, 399–404. [Google Scholar] [CrossRef] [PubMed]
  84. Cianci, S.; Tarascio, M.; Rosati, A.; Caruso, S.; Uccella, S.; Cosentino, F.; Scaletta, G.; Gueli Alletti, S.; Scambia, G. Sexual function and qulity of life of patients affected by ovarian cancer. Minerva Med. 2019, 110, 320–329. [Google Scholar] [CrossRef] [PubMed]
  85. Cianci, S.; Rosati, A.; Capozzi, V.A.; Tarascio, M.; Uccella, S.; Palumbo, M.A.; Caruso, S. Quality of life and sexual functioning of patient affected by endometrial cancer. Minerva Med. 2021, 112, 81–95. [Google Scholar] [CrossRef] [PubMed]
  86. Cohen, P.A.; Jhingran, A.; Oaknin, A.; Denny, L. Cervical cancer. Lancet 2019, 393, 169–182. [Google Scholar] [CrossRef]
  87. Johnson, C.A.; James, D.; Marzan, A.; Armaos, M. Cervical Cancer: An Overview of Pathophysiology and Management. Semin. Oncol. Nurs. 2019, 35, 166–174. [Google Scholar] [CrossRef]
  88. Stanley, M. Pathology and epidemiology of HPV infection in females. Gynecol. Oncol. 2010, 117, S5–S10. [Google Scholar] [CrossRef]
  89. Bruni, L.; Saura-Lázaro, A.; Montoliu, A.; Brotons, M.; Alemany, L.; Diallo, M.S.; Afsar, O.Z.; LaMontagne, D.S.; Mosina, L.; Contreras, M.; et al. HPV vaccination introduction worldwide and WHO and UNICEF estimates of national HPV immunization coverage 2010–2019. Prev. Med. 2020, 144, 106399. [Google Scholar] [CrossRef]
  90. Patel, C.; Brotherton, J.M.; Pillsbury, A.; Jayasinghe, S.; Donovan, B.; Macartney, K.; Marshall, H. The impact of 10 years of human papillomavirus (HPV) vaccination in Australia: What additional disease burden will a nonavalent vaccine prevent? Eurosurveillance 2018, 23, 1700737. [Google Scholar] [CrossRef] [Green Version]
  91. Farnsworth, A. Cervical cancer screening in Australia: Past and present. Cancer Cytopathol. 2015, 124, 231–234. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  92. Kramer, J. Eradicating cervical cancer: Lessons learned from Rwanda and Australia. Int. J. Gynecol. Obstet. 2021, 154, 270–276. [Google Scholar] [CrossRef] [PubMed]
  93. Santesso, N.; Mustafa, R.A.; Schünemann, H.J.; Arbyn, M.; Blumenthal, P.D.; Cain, J.; Chirenje, M.; Denny, L.; De Vuyst, H.; Eckert, L.O.; et al. World Health Organization Guidelines for treatment of cervical intraepithelial neoplasia 2–3 and screen-and-treat strategies to prevent cervical cancer. Int. J. Gynecol. Obstet. 2015, 132, 252–258. [Google Scholar] [CrossRef] [PubMed]
  94. Bhatla, N.; Aoki, D.; Sharma, D.N.; Sankaranarayanan, R. Cancer of the cervix uteri: 2021 update. Int. J. Gynecol. Obstet. 2021, 155 (Suppl. S1), 28–44. [Google Scholar] [CrossRef]
  95. Stefan, D.C.; Dangou, J.-M.; Barango, P.; Mahamadou, I.D.; Kapambwe, S. The World Health Organization targets for cervical cancer control by 2030: A baseline assessment in six African countries—Part I. Ecancermedicalscience 2022, 16, 1453. [Google Scholar] [CrossRef]
  96. Kjaer, S.K.; Dehlendorff, C.; Belmonte, F.; Baandrup, L. Real-World Effectiveness of Human Papillomavirus Vaccination Against Cervical Cancer. Gynecol. Oncol. 2021, 113, 1329–1335. [Google Scholar] [CrossRef]
  97. Athanasiou, S.; Pitsouni, E.; Grigoriadis, T.; Michailidis, G.; Tsiveleka, A.; Rodolakis, A.; Loutradis, D. A study protocol of vaginal laser therapy in gynecological cancer survivors. Climacteric 2020, 23, 53–58. [Google Scholar] [CrossRef]
  98. Hubbs, J.L.; Michelson, E.L.D.; Vogel, R.I.; Rivard, C.L.; Teoh, D.G.K.; Geller, M.A. Sexual quality of life after the treatment of gynecologic cancer: What women want. Support. Care Cancer 2019, 27, 4649–4654. [Google Scholar] [CrossRef]
  99. Murina, F.; Felice, R.; Di Francesco, S.; Nelvastellio, L.; Cetin, I. Ospemifene plus fractional CO2 laser: A powerful strategy to treat postmenopausal vulvar pain. Gynecol. Endocrinol. 2020, 36, 431–435. [Google Scholar] [CrossRef]
  100. Angioli, R.; Stefano, S.; Filippini, M.; Pieralli, A.; Montera, R.; Plotti, F.; Gatti, A.; Bartolone, M.; Luvero, D. Effectiveness of CO2 laser on urogenital syndrome in women with a previous gynecological neoplasia: A multicentric study. Int. J. Gynecol. Cancer 2020, 30, 590–595. [Google Scholar] [CrossRef]
  101. Vargiu, V.; Amar, I.D.; Rosati, A.; Dinoi, G.; Turco, L.C.; Capozzi, V.A.; Scambia, G.; Villa, P. Hormone replacement therapy and cervical cancer: A systematic review of the literature. Climacteric 2021, 24, 120–127. [Google Scholar] [CrossRef] [PubMed]
  102. DiNicola, S.; Pasta, V.; Costantino, D.; Guaraldi, C.; Bizzarri, M. Hyaluronic acid and vitamins are effective in reducing vaginal atrophy in women receiving radiotherapy. Minerva Obstet. Gynecol. 2015, 67, 523–531. [Google Scholar]
  103. D’Oria, O.; Giannini, A.; Buzzaccarini, G.; Tinelli, A.; Corrado, G.; Frega, A.; Vizza, E.; Caserta, D. Fractional Co2 laser for vulvo-vaginal atrophy in gynecologic cancer patients: A valid therapeutic choice? A systematic review. Eur. J. Obstet. Gynecol. Reprod. Biol. 2022, 277, 84–89. [Google Scholar] [CrossRef]
  104. dos Santos, C.C.M.; Uggioni, M.L.R.; Colonetti, T.; Colonetti, L.; Grande, A.J.; Da Rosa, M.I. Hyaluronic Acid in Postmenopause Vaginal Atrophy: A Systematic Review. J. Sex. Med. 2021, 18, 156–166. [Google Scholar] [CrossRef] [PubMed]
  105. Santen, R.J.; Stuenkel, C.A.; Davis, S.R.; Pinkerton, J.V.; Gompel, A.; Lumsden, M.A. Managing Menopausal Symptoms and Associated Clinical Issues in Breast Cancer Survivors. J. Clin. Endocrinol. Metab. 2017, 102, 3647–3661. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  106. Martins, J.; Vaz, A.F.; Grion, R.C.; Costa-Paiva, L.; Baccaro, L.F. Topical estrogen, testosterone, and vaginal dilator in the prevention of vaginal stenosis after radiotherapy in women with cervical cancer: A randomized clinical trial. BMC Cancer 2021, 21, 682. [Google Scholar] [CrossRef]
  107. Logan, S.; Anazodo, A. The psychological importance of fertility preservation counseling and support for cancer patients. Acta Obstet. Gynecol. Scand. 2019, 98, 583–597. [Google Scholar] [CrossRef] [Green Version]
  108. Schultz, W.C.M.W.; Van de Wiel, H.B.M.; Hahn, D.E.E.; Bouma, J. Psychosexual functioning after treatment for gynecologi-cal cancer: An integrative model, review of determinant factors and clinical guidelines. Int. J. Gynecol. Cancer 1992, 2, 281–290. [Google Scholar] [CrossRef]
  109. Plotti, F.; Nelaj, E.; Sansone, M.; Antonelli, E.; Altavilla, T.; Angioli, R.; Panici, P.B. Sexual Function after Modified Radical Hysterectomy (Piver II/Type B) vs. Classic Radical Hysterectomy (Piver III/Type C2) for Early Stage Cervical Cancer. A Prospective Study. J. Sex. Med. 2012, 9, 909–917. [Google Scholar] [CrossRef]
  110. Plotti, F.; Sansone, M.; Di Donato, V.; Antonelli, E.; Altavilla, T.; Angioli, R.; Panici, P.B. Quality of life and sexual function after type C2/type III radical hysterectomy for locally advanced cervical cancer: A prospective study. J. Sex. Med. 2011, 8, 894–904. [Google Scholar] [CrossRef]
Medicina 59 00704 g001 550
Figure 1. PRISMA flowchart for research strategy for the selected studies.
Figure 1. PRISMA flowchart for research strategy for the selected studies.
Medicina 59 00704 g001
Table
Table 1. The included studies and their characteristics.
Table 1. The included studies and their characteristics.
AuthorStudy DesignNumber of Patients and FeaturesPurposeQuestionnaireStudy Findings
Kirchheiner
[38]
2021		Prospective study1045 ptsSF in CCEORTC QLQ-CX 2460% were sexually active after treatment;
Vaginal symptoms were negatively correlated with sexual enjoyment (p ≤ 0.001).
Novackova
[39]
2022		Prospective study36 ptsSF in early stage CC with nerve sparing radical hysterctomy therapy FSFI
EORTC QLQ-CX 24
EORTC QLQ-C30		Decreased sexual functioning after surgery, but no changes in sexual activity, enjoyment of worry
Park
[40]
2007		Retrospective case-control study860 pts
494 CG		SF in CCEORTC QLQ-C30CC pts had more sexual disfunction compared to CG. CC pts who received both surgery and adjuvant therapy than surgery alone reported significantly worse sexual or vaginal problems
Jensen [41]
2003		Multicenter prospective case-control study173 pts
328 CG		SF after RH in CCSVQ
EORTC		CC had more vaginal symptoms,
91% were sexually active before and after surgery, but with a decrease of frequency
Ljuca
[42]
2010		Retrospective-prospective study35 ptsSF before and after chemoradiotherapy in CCEORTC QLQ-CX 24Improvement of vaginal function after chemoradiotherapy, but no difference in SF before and after therapy
Bakker
[43]
2011		Cross-sectional study252 ptsSF in CCFSDS
EORTC QLQ-CX24
HADS
MMQ		38% CC had sexual distress; it was associated with vaginal symptoms and body imagine concerns
Aerts
[44]
2014		Prospective case-control study31 pts
93 CG
93 TLH		Compare SF in CC who only underwent surgery RH vs. healthy control group and womaen who underwent TLH for benign gynecological diseaseSSFS
SSPQ		The CC compared to the healthy group had a high risk of sexual disfunction;
No difference in SF for CC compared to women with benign conditions
Correa
[45]
2015		Retrospective case control study37 pts
37 CG		SF in CCFSFICC decreased SF by
64.9%, vaginal stenosis by
59.5%, not sexually active was at
80%, and who were sexually active had sexual dysfunction
Lee
[46]
2016		Cross-sectional, case-control study104 pts
CG 104		compare SF between sexually active CC and healthy women.EORTC QLQ-C30
EORTC QLQ-CX24
FSFI		No difference in SF
Carter
[47]
2010		Prospective study52 pts: 33 RT + 19 RHSF and QOL in early-stage cervical cancer undergoing RT or RHFSFIFSFI mean scores were below 26.55—the clinical cut-off;
No difference in SF between group with RH and RT
Hofsjö
[48]
2017		Retrospective case-control study34 pts
37 CG		SF in CCa questionnaire designed to assess sexual functionReduced satisfaction in sex, lubrification, elasticity and vaginal length;
No differences in interest in sex between the pts and the CG in physical and psychological wellbeing and level of anxiety and depression
De Rosa
[49]
2017		Prospective study52 ptsEvaluates the effect on VHI, QoL, and SF of ospemifene in CC survivors.EORTC QLQ-C30Improvement of body image, sexual enjoyment and SF
Plotti
[50]
2017		Retrospective study90 ptsSF in long-term CC survivor affected by LACC and treated with type C2/type III RHEORTC QLQ-CX24
EORTC QLQ-C30		Good level of sexual enjoyment with a slight worsening of sexual activity
Bae
[51]
2015		Cross-sectional study137 PtsTo examine the level of
sexual function, depression and quality of life in CC pts		FSFI
HADS
FACT-G		CC pts had low sexual functionand about 45.4% of them experienced more than a moderate level of depression.
Also, pts with lower sexual function had lower QoL and higher levels of depression
Serati
[52]
2009		Prospective case-control study38 pts (20 laparoscopic RH, 18 laparotomic RH)
35 CG		SF after RH vs. a control group of healthy women
SF after laparoscopic RH vs. laparotomic RH		FSFIRH worsens SF, without any significative difference between laparoscopy and laparotomy
Shi
[53]
2020		RCT91 pts RH:
intervention group n = 46 control group n = 45		To assess the efficacy of a nurse-led positive psychology intervention on sexual function, depression and subjective well-being among postop pts with early CCFSFISexual function, depression and subjective well-being were significantly improved in the intervention group
Cerentini
[54]
2019		Prospective case-control study88 ptsuse of vaginal dilators after brachytherapy in CC. EORTC QLQ-C30vaginal dilators did not increase the dimension of thevagina
Mihai Stanca
[55]
2022 		Retrospective observational study430 ptsQoL and SF in CCEORTC QLQ-CX 24
QLQ-C30		Decreased sexual function, activity and enjoyment
CG = control group—Pts = Patients. SF = sexual function—SVQ = Sexual function-Vaginal changes Questionnaire. RCT = randomized controlled study—FSFI = Female Sexual Function Index. RH = radical hysterectomy—FSDS = Female Sexual Distress Scale. RT = radical trachelectomy—LACC = Local advanced cervical cancer. Postop = postoperative—QoL = Quality of life. BIS = Body Images Scale—EORTC QLQ-C30 (European Organization and Treatment of Cancer QLQ-C30. SSFS= Short Sexual Functioning Scale—EORTC QLQ-CX24 = Quality of Life Questionnaire for Cervical Cancer. SSPQ = Specific Sexual Problems Questionnaire—MMQ = Maudsley Marital Questionnaire.HADS = Hospital Anxiety and Depression scale—FACT-G = Functional Assessment of Cancer Therapy–General.
Table
Table 2. The main reported reasons for sexual disfunction.
Table 2. The main reported reasons for sexual disfunction.
No interest in sex [39,40,41,42,43,44,46,49]
Physical problem (depression, anxiety, surgical scar) [40,43,44,46,47,51,52,54]
No partner [39,41,43,44,45]
Vaginal dryness [38,39,40,41,48,49,50,52,54]
Dyspareunia and pain [39,40,41,42,43,47,49,53]
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Cianci, S.; Tarascio, M.; Arcieri, M.; La Verde, M.; Martinelli, C.; Capozzi, V.A.; Palmara, V.; Gulino, F.; Gueli Alletti, S.; Caruso, G.; et al. Post Treatment Sexual Function and Quality of Life of Patients Affected by Cervical Cancer: A Systematic Review. Medicina 2023, 59, 704. https://doi.org/10.3390/medicina59040704

AMA Style

Cianci S, Tarascio M, Arcieri M, La Verde M, Martinelli C, Capozzi VA, Palmara V, Gulino F, Gueli Alletti S, Caruso G, et al. Post Treatment Sexual Function and Quality of Life of Patients Affected by Cervical Cancer: A Systematic Review. Medicina. 2023; 59(4):704. https://doi.org/10.3390/medicina59040704

Chicago/Turabian Style

Cianci, Stefano, Mattia Tarascio, Martina Arcieri, Marco La Verde, Canio Martinelli, Vito Andrea Capozzi, Vittorio Palmara, Ferdinando Gulino, Salvatore Gueli Alletti, Giuseppe Caruso, and et al. 2023. "Post Treatment Sexual Function and Quality of Life of Patients Affected by Cervical Cancer: A Systematic Review" Medicina 59, no. 4: 704. https://doi.org/10.3390/medicina59040704

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