Efficacy and Safety of Endoscopic Ultrasound-Guided Radiofrequency Ablation for Pancreatic Neuroendocrine Tumors: A Systematic Review and Metanalysis
Abstract
:1. Introduction
2. Materials and Methods
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Study, Year | Study Design | N of Patients/ N of F-PanNET | Male/ Female | Age | Tumor Size (mean, mm) | Location | Device | N of RFA Sessions /Nodule | Efficacy * | Adverse Events | Follow-Up Months |
---|---|---|---|---|---|---|---|---|---|---|---|
Lakhtakia [14], 2016 | Retrospective | 3/3 | M | 45 | 19 | H | 19 G, Starmed | 1 | 100 | 0 | 11.5 |
Waung [15], 2016 | Retrospective | 1/1 | F | 70 | 18 | H | Habib EUS RFA | 3 | 100 | 0 | 10 |
Bas-Cutrina [16], 2017 | Retrospective | 1/1 | F | 63 | 10 | NR | Habib EUS RFA | 1 | 100 | 0 | 10 |
Choi [17], 2018 | Prospective | 1/1 | M | 34 | 12 | H | 19G, Starmed | 1 | 100 | 0 | 13 |
Thosani [18], 2018 | Retrospective | 3/3 | NR | NR | NR | NR | NR | 1.6 ° | 100 | 1 | 5 |
Gueneau de Mussy [19], 2018 | Retrospective | 1/1 | F | 69 | 12 | T | 19G, Starmed | 1 | 100 | 1 | 2 |
Klutz [20], 2019 | Retrospective | 1/1 | M | 40 | 9 | H | 19G, Starmed | 1 | 100 | 1 | 6 |
Oleinikov [21], 2019 | Retrospective | 7/7 | 4M, 3F | 60.4 | 14.9 | H:7, T:2 | 19G, Starmed | 1 | 100 | 0 | 9.7 |
De Nucci [22], 2020 | Prospective | 5/5 | 2M, 3F | 80 | 12.8 | T | 19 G, Starmed | 1 | 100 | 0 | 12 |
Brown [23], 2020 | Retrospective | 1/1 | F | 66 | 18 | H | 19 G, Starmed | 1 | 100 | 0 | 8 |
Marx [24], 2022 | Retrospective | 7/7 | 1M, 6F | 66 | 13.3 | H:1; T:6 | 19 G, Starmed | 1 | 85,7 | 4 | 21 |
Rizzatti [25], 2022 | Prospective | 30/30 | 10M, 20F | 61.9 | 11.9 | H:12, T:18 | 19 G, Starmed | 25:1; 4:2; 1:3 | 95,8 | 3 | 6 |
Lakhtakia [26] | Retrospective | 12/12 | NR | NR | NR | NR | 19 G, Starmed | NR | 100 | NR | 31.5 |
Nabi [27], 2022 | Retrospective | 12/15 | 7M/8F | 46.7 | NR | H:8T:7 | 19 G, Starmed | 1: 10 >1:2 | 100 | 1 | 41 |
Borrelli deAndreis [28] in press | Retrospective | 10/10 | 7M, 3F | 11.9 | 11,9 | H:3, T:7 | 19 G, Starmed | 9:1,1:2 | 100 | 3 | 3 |
Rossi [29], 2022 | Retrospective | 3/3 | 2M, 1F | 82.7 | 12 | H:1, T:2 | 19 G, Starmed | 1:2; 2:1 | 100 | 1 | 24 |
Study, Year | Study Design | N of Patients/ N of NF- PanNETs | Male/ Female | Age | Tumor Size (mean, mm) | Location | Device | N of RFA Sessions per Nodule | Efficacy * | N of Adverse Events | Follow-Up (Months) |
---|---|---|---|---|---|---|---|---|---|---|---|
Rossi [11], 2014 | Retrospective | 1/1 | M | 72 | 9 | T | Habib EUS RFA | 1 | 100 | 0 | 34 |
Armellini [13], 2015 | Retrospective | 1/1 | M | 76 | 20 | T | 18 G, Starmed | 1 | 100 | 0 | 1 |
Pai [12],2015 | Prospective | 2/2 | F | 69.5 | 27.5 | H | Habib EUS RFA | 1:1,1:2 | 100 | 2 | 6 |
Choi [17], 2018 | Retrospective | 7/7 | 3M, 4F | 56.1 | 20 | H:2, T:5 | 19 G, Starmed | 1:3, 2:2, 3:2 | 75 | 2 | 13 |
Barthet [5], 2018 | Prospective | 12/14 | 7M, 5F | 59.9 | 13.1 | H:3, T:11 | 19 G, Starmed | NR | 86 | 2 | 12 |
Oleinikov [21], 2019 | Retrospective | 11/18 | 6M, 5F | 65.8 | 14.2 | H;11, T:7 | 19 G, Starmed | 1 | 94.5 | 2 | 8.7 |
De Nucci [22], 2020 | Prospective | 5/6 | 3M, 2F | 77.2 | 14.2 | H:3, T:3 | 19 G, Starmed | 1 | 100 | 2 | 12 |
Rizzatti [25], 2022 | Prospective | 32/32 | 22M, 10F | 70.1 | 14.2 | H:11, T: 21 | 19 G, Starmed | 1:24, 2:7, 3:1 | 96.3 | 0 | 8 |
Lakthakia [26], 2022 | Retrospective | 14/14 | NR | NR | NR | NR | 19 G, Starmed | NR | 85.7 | NR | 31.5 |
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Armellini, E.; Facciorusso, A.; Crinò, S.F. Efficacy and Safety of Endoscopic Ultrasound-Guided Radiofrequency Ablation for Pancreatic Neuroendocrine Tumors: A Systematic Review and Metanalysis. Medicina 2023, 59, 359. https://doi.org/10.3390/medicina59020359
Armellini E, Facciorusso A, Crinò SF. Efficacy and Safety of Endoscopic Ultrasound-Guided Radiofrequency Ablation for Pancreatic Neuroendocrine Tumors: A Systematic Review and Metanalysis. Medicina. 2023; 59(2):359. https://doi.org/10.3390/medicina59020359
Chicago/Turabian StyleArmellini, Elia, Antonio Facciorusso, and Stefano Francesco Crinò. 2023. "Efficacy and Safety of Endoscopic Ultrasound-Guided Radiofrequency Ablation for Pancreatic Neuroendocrine Tumors: A Systematic Review and Metanalysis" Medicina 59, no. 2: 359. https://doi.org/10.3390/medicina59020359