Comparing the Influence of Surgical and Conservative Therapy on Quality of Life in Patients with Early-Stage Medication-Related Osteonecrosis of the Jaw—A Prospective Longitudinal Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design
2.2. Patients
2.3. Data Collection
2.4. Questionnaires (QLQ-C30, OHIP G49)
2.5. Statistical Analysis
3. Results
3.1. Patient Characteristics
3.2. OHIP
3.3. QLQ-C30
4. Discussion
5. Conclusions
- Surgical and conservative treatment of MRONJ stage I significantly improves patients’ OHRQoL.
- Surgical treatment is superior to conservative treatment of MRONJ stage I regarding general QoL.
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Surgical Treatment | Conservative Treatment | |||
---|---|---|---|---|
N | % | N | % | |
Gender | ||||
Female | 86 | 61.4 | 22 | 64.7 |
Male | 54 | 38.6 | 12 | 35.3 |
Age (years) | ||||
Mean | 70.3 | 69.6 | ||
SD | 13.2 | 11.3 | ||
Cancer types | ||||
Breast | 38 | 27.1 | 16 | 47.1 |
Prostate | 29 | 20.7 | 5 | 14.7 |
Renal | 6 | 4.3 | 3 | 8.8 |
Multiple myeloma | 19 | 13.6 | 10 | 29.4 |
Osteoporosis | 36 | 25.7 | 0 | 0 |
Others | 12 | 8.6 | 0 | 0 |
Bone metastasis | ||||
No | 36 | 25.7 | 0 | 0 |
Yes | 85 | 60.7 | 24 | 70.6 |
Multiple Myeloma | 19 | 13.6 | 10 | 29.4 |
Antiresorptive Treatment | ||||
Bisphosphonates | 105 | 75.0 | 27 | 79.4 |
Denosumab | 28 | 20.0 | 6 | 17.6 |
Both | 7 | 5.0 | 1 | 2.9 |
Duration antiresorptive treatment (months) | ||||
Mean | 53.7 | 55.8 | ||
SD | 41.3 | 42.4 |
Surgical Treatment | Non-Surgical Treatment | p-Value for Group Difference, Two-Tailed | |||
---|---|---|---|---|---|
Timepoint | Mean | SD | Mean | SD | |
T0 | 14.1 | 11.6 | 17.1 | 11.8 | 0.175 |
T1 | 11.1 | 11.5 | 11.6 | 11.3 | 0.808 |
T2 | 8.9 | 11.5 | 8.1 | 10.9 | 0.698 |
T3 | 6.7 | 10.7 | 4.4 | 8.2 | 0.241 |
Surgical Treatment | Non-Surgical Treatment | p-Value for Group Difference, Two-Tailed | |||
---|---|---|---|---|---|
Timepoint | Mean | SD | Mean | SD | |
T0 | 55.1 | 22.0 | 49.0 | 21.7 | 0.159 |
T1 | 55.8 | 26.1 | 44.3 | 23.1 | 0.036 * |
T2 | 50.5 | 25.6 | 40.6 | 23.1 | 0.095 |
T3 | 58.6 | 17.5 | 46.5 | 26.7 | 0.047 * |
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Rückschloß, T.; Smielowski, M.; Moratin, J.; Schnug, G.; Appel, M.; Muench, P.; Bleymehl, M.; Zittel, S.; Engel, M.; Hoffmann, J.; et al. Comparing the Influence of Surgical and Conservative Therapy on Quality of Life in Patients with Early-Stage Medication-Related Osteonecrosis of the Jaw—A Prospective Longitudinal Study. Medicina 2023, 59, 277. https://doi.org/10.3390/medicina59020277
Rückschloß T, Smielowski M, Moratin J, Schnug G, Appel M, Muench P, Bleymehl M, Zittel S, Engel M, Hoffmann J, et al. Comparing the Influence of Surgical and Conservative Therapy on Quality of Life in Patients with Early-Stage Medication-Related Osteonecrosis of the Jaw—A Prospective Longitudinal Study. Medicina. 2023; 59(2):277. https://doi.org/10.3390/medicina59020277
Chicago/Turabian StyleRückschloß, Thomas, Maximilian Smielowski, Julius Moratin, Gregor Schnug, Maximilian Appel, Philipp Muench, Moritz Bleymehl, Sven Zittel, Michael Engel, Jürgen Hoffmann, and et al. 2023. "Comparing the Influence of Surgical and Conservative Therapy on Quality of Life in Patients with Early-Stage Medication-Related Osteonecrosis of the Jaw—A Prospective Longitudinal Study" Medicina 59, no. 2: 277. https://doi.org/10.3390/medicina59020277