Exploring Verbal Fluency Strategies among Individuals with Normal Cognition, Amnestic and Non-Amnestic Mild Cognitive Impairment, and Alzheimer’s Disease
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Assessments
2.2. Outcome Measures and Statistical Analysis
3. Results
3.1. Baseline Characteristics and Missing Data
3.2. Differences in Verbal Fluency Strategies among Groups Based on Cognitive Status
3.3. Differences in Verbal Fluency Strategies among MCI Subtype Groups
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Parameter | NC (n = 1607) | aMCI (n = 146) | naMCI (n = 92) | AD (n = 79) | |
---|---|---|---|---|---|
Age in years (N = 1924) | 73.31 ± 5.19 | 74.84 ± 5.20 | 75.91 ± 5.26 | 79.96 ± 6.36 | |
Gender (M/F) (N = 1924) | 643/964 (40.0%/60.0%) | 65/81 (45.5%/55.5%) | 39/53 (42.4%/57.6%) | 32/47 (40.5%/59.5%) | |
Years of education (N = 1923) | 8.17 ± 4.86 | 7.20 ± 5.44 | 6.92 ± 4.78 | 6.87 ± 5.30 | |
Semantic task (N = 1873) | Production | 15.70 ± 4.98 | 11.30 ± 5.12 | 13.58 ± 5.48 | 7.77 ± 4.73 |
Number of clusters | 2.27 ± 1.31 | 1.62 ± 1.16 | 2.07 ± 1.23 | 1.13 ± 1.06 | |
Number of switches | 9.70 ± 4.71 | 7.28 ± 4.23 | 8.07 ± 4.55 | 4.29 ± 3.00 | |
Number of errors | 0.62 ± 1.51 | 0.65 ± 2.15 | 0.49 ± 1.34 | 0.30 ±0.81 | |
Number of perseverations | 0.57 ± 1.01 | 0.60 ± 0.99 | 0.48 ± 0.87 | 0.29 ± 0.66 | |
Phonemic task (N = 1815) | Production | 7.39 ± 4.52 | 4.92 ± 4.14 | 5.72 ± 3.67 | 3.57 ± 3.69 |
Number of clusters | 0.33 ± 0.74 | 0.08 ± 0.27 | 0.16 ± 0.45 | 0.13 ± 0.34 | |
Number of switches | 6.53 ± 4.10 | 4.68 ± 4.06 | 5.31 ± 3.12 | 3.28 ± 3.53 | |
Number of errors | 0.26 ± 0.75 | 0.30 ± 0.76 | 0.27 ± 0.56 | 0.53 ± 1.26 | |
Number of perseverations | 0.36 ± 0.83 | 0.22 ± 0.56 | 0.16 ± 0.42 | 0.18 ± 0.79 |
Parameter | NC vs. aMCI | NC vs. naMCI | NC vs.AD | aMCI vs. naMCI | aMCI vs. AD | naMCI vs. AD | |
---|---|---|---|---|---|---|---|
Semantic task | Number of clusters | 0.57 (0.27, 0.87), <0.001 | 0.11 (−0.25, 0.48), 1.000 | 0.90 (0.47, 1.33), <0.001 | −0.45 (−0.91, 0.00), 0.051 | 0.34 (−0.17, 0.84), 0.480 | 0.79 (0.24, 1.33), >0.001 |
Number of switches | 1.71 (0.74, 2.69), <0.001 | 0.83 (−0.36, 2.02), 0.389 | 4.21 (2.81, 5.61), <0.001 | −0.88 (−2.36, 0.60), 0.694 | 2.50 (0.85, 4.14), <0.001 | 3.38 (1.61, 5.14), <0.001 | |
Number of errors | −0.04 (−0.41, 0.32), 1.000 | 0.18 (−0.41, 0.32), 1.000 | 0.42 (−0.11, 0.95), 0.208 | 0.22 (−0.33, 0.78), 1.000 | 0.46 (−0.15, 1.08), 0.284 | 0.24 (−0.42, 0.91), 1.000 | |
Number of perseverations | −0.04 (−0.27, 0.20), 1.000 | 0.09 (−0.20, 0.37), 1.000 | 0.26 (−0.09, 0.59), 0.282 | 0.12 (−0.24, 0.48), 1.000 | 0.29 (−0.10, 0.69), 0.310 | 0.17 (−0.26, 0.60), 1.000 | |
Phonemic task | Number of clusters | 0.22 (0.06, 0.37), 0.002 | 0.13 (−0.07, 0.32), 0.515 | 0.15 (−0.08, 0.38), 0.504 | −0.09 (−0.33, 0.15), 1.000 | −0.07 (−0.33, 0.20), 1.000 | 0.02 (−0.27, 0.31), 1.000 |
Number of switches | 1.37 (0.56, 2.19), <0.001 | 0.50 (−0.50, 1.49), 1.000 | 2.33 (1.16, 3.50), <0.001 | −0.88 (−2.11, 0.36), 0.363 | 0.96 (−0.42, 2.33), 0.398 | 1.83 (0.36, 3.31), 0.006 | |
Number of errors | −0.04 (−0.22, 0.14), 1.000 | −0.01 (−0.23, 0.22), 1.000 | −0.26 (−0.52, 0.00), 0.055 | 0.04 (−0.14, 0.22), 1.000 | −0.22 (−0.52, 0.08), 0.355 | −0.25 (−0.58, 0.08), 0.258 | |
Number of perseverations | 0.12 (−0.06, 0.30), 0.494 | 0.17 (−0.06, 0.39), 0.293 | 0.14 (−0.13, 0.40), 1.000 | 0.05 (−0.23, 0.33), 1.000 | 0.02 (−0.29, 0.33), 1.000 | −0.03 (−0.36, 0.30), 1.000 |
Parameter | maMCI vs. aMCI | maMCI vs. naMCI | maMCI vs. mnaMCI | aMCI vs. naMCI | aMCI vs. mnaMCI | mnaMCI vs. naMCI | |
---|---|---|---|---|---|---|---|
Semantic task | Number of clusters | −0.17 (−0.76, 0.42), 1.000 | −0.52 (−1.15, 0.07), 0.117 | −0.52 (−1.07, 0.04), 0.080 | −0.35 (−1.05, 0.34), 1.000 | −0.35 (−1.00, 0.31), 0.955 | −0.01 (−0.67, 0.66), 1.000 |
Number of switches | −1.87 (−3.77, 0.03), 0.057 | −2.85 (−4.77, −0.93), 0.001 | −0.32 (−2.11, 1.47), 1.000 | −0.98 (−3.22, 1.26), 1.000 | 1.55 (−0.56, 3.67), 0.323 | −2.53 (−4.68, 0.38), 0.012 | |
Number of errors | 0.70 (−0.24, 1.63), 0.292 | 0.53 (−0.41, 1.47), 0.806 | 0.32 (−0.56, 1.19), 1.000 | −0.16 (−1.26, 0.93), 1.000 | −0.38 (−1.42, 0.66), 1.000 | 0.21 (−0.84, 1.27), 1.000 | |
Number of perseverations | −0.19 (−0.66, 0.28), 1.000 | 0.20 (−0.27, 0.68), 1.000 | 0.02 (−0.42, 0.46), 1.000 | 0.39 (−0.17, 0.94), 0.379 | 0.20 (−0.32, 0.73), 1.000 | 0.18 (−0.35, 0.71), 1.000 | |
Phonemic task | Number of clusters | −0.07 (−0.25, 0.10), 1.000 | −0.15 (−0.33, 0.03), 0.116 | −0.07 (−0.24, 0.09), 1.000 | −0.08 (−0.28, 0.12), 1.000 | −0.00 (−0.19, 0.19), 1.000 | −0.08 (−0.27, 0.12), 1.000 |
Number of switches | −0.85 (−2.42, 0.72), 0.899 | −1.65 (−3.23, −0.06), 0.037 | −0.78 (−2.26, 0.69), 0.942 | −0.79 (−2.64, 1.06), 1.000 | 0.07 (−1.69, 1.82), 1.000 | −0.86 (−2.63, 0.92), 1.000 | |
Number of errors | −0.09 (−0.43, 0.26), 1.000 | 0.01 (−0.34, 0.36), 1.000 | −0.03 (−0.35, 0.30), 1.000 | 0.10 (−0.31, 0.50), 1.000 | 0.06 (−0.32, 0.45), 1.000 | 0.03 (−0.36, 0.42), 1.000 | |
Number of perseverations | −0.22 (−0.47, 0.03), 0.136 | 0.03 (−0.23, 0.21), 1.000 | −0.02 (−0.26, 0.21), 1.000 | 0.24 (−0.05, 0.54), 0.183 | 0.41 (−0.09, 0.47), 0.408 | 0.05 (−0.23, 0.33), 1.000 |
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Bairami, S.; Folia, V.; Liampas, I.; Ntanasi, E.; Patrikelis, P.; Siokas, V.; Yannakoulia, M.; Sakka, P.; Hadjigeorgiou, G.; Scarmeas, N.; et al. Exploring Verbal Fluency Strategies among Individuals with Normal Cognition, Amnestic and Non-Amnestic Mild Cognitive Impairment, and Alzheimer’s Disease. Medicina 2023, 59, 1860. https://doi.org/10.3390/medicina59101860
Bairami S, Folia V, Liampas I, Ntanasi E, Patrikelis P, Siokas V, Yannakoulia M, Sakka P, Hadjigeorgiou G, Scarmeas N, et al. Exploring Verbal Fluency Strategies among Individuals with Normal Cognition, Amnestic and Non-Amnestic Mild Cognitive Impairment, and Alzheimer’s Disease. Medicina. 2023; 59(10):1860. https://doi.org/10.3390/medicina59101860
Chicago/Turabian StyleBairami, Styliani, Vasiliki Folia, Ioannis Liampas, Eva Ntanasi, Panayiotis Patrikelis, Vasileios Siokas, Mary Yannakoulia, Paraskevi Sakka, Georgios Hadjigeorgiou, Nikolaos Scarmeas, and et al. 2023. "Exploring Verbal Fluency Strategies among Individuals with Normal Cognition, Amnestic and Non-Amnestic Mild Cognitive Impairment, and Alzheimer’s Disease" Medicina 59, no. 10: 1860. https://doi.org/10.3390/medicina59101860