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Medicina
Volume 59
Issue 1
10.3390/medicina59010148
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Article
Peer-Review Record

Allogeneic Umbilical Cord-Blood-Derived Mesenchymal Stem Cells and Hyaluronate Composite Combined with High Tibial Osteotomy for Medial Knee Osteoarthritis with Full-Thickness Cartilage Defects

Medicina 2023, 59(1), 148; https://doi.org/10.3390/medicina59010148
by Yong-Beom Park 1,*, Han-Jun Lee 2, Hyun-Cheul Nam 2 and Jung-Gwan Park 3
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Medicina 2023, 59(1), 148; https://doi.org/10.3390/medicina59010148
Submission received: 23 November 2022 / Revised: 31 December 2022 / Accepted: 5 January 2023 / Published: 11 January 2023
(This article belongs to the Special Issue Advances in Knee Surgery)

Round 1

Reviewer 1 Report

thanks for submitting this paper

this is a small case series aimed to report the results of HTO+UCB-MSCs in patients with cartilage defects and limb malalignment.

overall well-written paper with some major methodological issues

main flaws of the study are (1) small sample size, (2) no control group, (3) short follow-up [1 year? please report standard deviation for FU time]

COMMENTS
-please be sure that the manuscript is revised by a proficient English speaker researcher
-please be sure that references are correctly formatted, relevant, and updated

-abstract: well written

-line 67: please report the study design

-figure 1 (you had 14 patients with cartilage procedures, why you chose not to include a control group?)

line 121 (how were radiological measurements performed and how reliable were these ?)

line 129 (please report sample size calculation)

results: well written

 

 

 

Author Response

Please see the attached file. 

Thank you.

Author Response File: Author Response.docx

Reviewer 2 Report

This paper is well written . I have only  one addition if they have 65 patients with HTO s why not compare the outcomes of the 12 with the 50 or so patients who did not have this procedure . it would make a great paper. 

Author Response

Thank you for your comment. We know that the comparison with the control group makes this manuscript better. However, we focused on cartilage repair following novel MSCs product implantation in this study. 

Someday, we will prepare the comparison study according to your comment. 

Thank you. 

Round 2

Reviewer 1 Report

thanks for your revision

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