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Article

HPV and HIV Coinfection in Women from a Southeast Region of Romania—PICOPIV Study

1
Faculty of Medicine, Ovidius University of Constanta, 1 Universitatii Street, 900470 Constanta, Romania
2
Clinical Hospital of Infectious Diseases, 100 Ferdinand Blvd., 900178 Constanta, Romania
3
Center for Research and Development of the Morphological and Genetic Studies of Malignant Pathology, Ovidius University of Constanta, 145 Tomis Blvd., 900591 Constanta, Romania
4
Institute of Doctoral Studies, Ovidius University of Constanta, 1 Universitatii Street, 900470 Constanta, Romania
5
Sf. Apostol Andrei Emergency County Hospital, 145 Tomis Blvd., 900591 Constanta, Romania
6
Clinical Hospital of Infectious Disease Sf. Cuvioasa Parascheva, 393 Traian Street, 800179 Galati, Romania
7
Faculty of Dentistry, Ovidius University of Constanta, 1 Universitatii Street, 900470 Constanta, Romania
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Won Suk Choi and Iosif Marincu
Medicina 2022, 58(6), 760; https://doi.org/10.3390/medicina58060760
Received: 18 April 2022 / Revised: 24 May 2022 / Accepted: 31 May 2022 / Published: 3 June 2022
(This article belongs to the Special Issue Pathogenesis, Diagnostics, and Therapeutics of Infectious Diseases)
Background and Objectives: Romania faces one of the highest cervical cancer burdens in Europe though it is a preventable cancer through population screening by cytology and human papillomavirus (HPV) detection. Also, it has one of the highest incidences of human immunodeficiency virus (HIV) infection. HPV and HIV coinfection are frequently encountered. The aim of study was to establish the prevalence of HPV infection among HIV-positive women in Southeast Region of Romania, to genotype high risk HPV types -and to correlate the results with clinical data and cytological cervical lesions. Materials and Methods: 40 HIV-positive women were screened for HPV types and for cytological cervical lesions. The findings were evaluated in correlation with CD4 cell counts, HIV viral load, age at first sexual intercourse, number of sexual partners, vaginal candidiasis, and Gardnerella using statistical methods. Results: 19/40 (47.5%) women were positive for HPV types, 63.15% infected with single HPV type and 36.85% with multiple HPV types. The most frequent types were type: 31 (42.1%), 56 (31.57%), 53 (15.78%). On cytology, 34 (85%) women were found with NILM of which 38.23% were HPV-positive. Fifteen percent of women had abnormal cytology (three ASC-US, three LSIL), and all of them were HPV-positive. Through analyzing the value of CD4 count, women with CD4 count ≤ 200 cells/μL were found to be significantly more likely to be infected with HPV; meanwhile there was no correlation between the detection of HPV types and HIV viral load. Candida or Gardnerella were more often associated with HIV-positive women with HPV, than in women without HPV. Conclusions: Infection with HPV types is common among HIV-positive women in the Southeast Region of Romania and it is associated with age at the beginning of sexual life, number of sexual partners, CD4 value, vaginal candidiasis, and Gardnerella infection. View Full-Text
Keywords: HIV; HPV; high risk; coinfection; cervical precancerous lesions; pap cytology; CD4; antiretroviral therapy HIV; HPV; high risk; coinfection; cervical precancerous lesions; pap cytology; CD4; antiretroviral therapy
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MDPI and ACS Style

Cambrea, S.C.; Aschie, M.; Resul, G.; Mitroi, A.F.; Chisoi, A.; Nicolau, A.A.; Baltatescu, G.I.; Cretu, A.M.; Lupasteanu, G.; Serbanescu, L.; Manea, M.; Topliceanu, S.T.; Petcu, L.C.; Pazara, L.; Cozaru, G.C. HPV and HIV Coinfection in Women from a Southeast Region of Romania—PICOPIV Study. Medicina 2022, 58, 760. https://doi.org/10.3390/medicina58060760

AMA Style

Cambrea SC, Aschie M, Resul G, Mitroi AF, Chisoi A, Nicolau AA, Baltatescu GI, Cretu AM, Lupasteanu G, Serbanescu L, Manea M, Topliceanu ST, Petcu LC, Pazara L, Cozaru GC. HPV and HIV Coinfection in Women from a Southeast Region of Romania—PICOPIV Study. Medicina. 2022; 58(6):760. https://doi.org/10.3390/medicina58060760

Chicago/Turabian Style

Cambrea, Simona Claudia, Mariana Aschie, Ghiulendan Resul, Anca Florentina Mitroi, Anca Chisoi, Antonela Anca Nicolau, Gabriela Izabela Baltatescu, Ana Maria Cretu, Gabriela Lupasteanu, Lucian Serbanescu, Mihaela Manea, Sebastian Theodor Topliceanu, Lucian Cristian Petcu, Loredana Pazara, and Georgeta Camelia Cozaru. 2022. "HPV and HIV Coinfection in Women from a Southeast Region of Romania—PICOPIV Study" Medicina 58, no. 6: 760. https://doi.org/10.3390/medicina58060760

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