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Diagnostic Value of Non-invasive Scoring Systems in the Prediction of Esophageal Varices in Patients with Liver Cirrhosis—Single Center Experience

1
Clinic of Gastroenterology and Hepatology, Clinical Center of Serbia, 11000 Belgrade, Serbia
2
Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia
*
Authors to whom correspondence should be addressed.
Academic Editors: Hirayuki Enomoto and Tatsuo Kanda
Medicina 2022, 58(2), 158; https://doi.org/10.3390/medicina58020158
Received: 11 December 2021 / Revised: 13 January 2022 / Accepted: 17 January 2022 / Published: 20 January 2022
(This article belongs to the Topic Liver Fibrosis and Cirrhosis)
Background and Objectives: Upper endoscopy is considered the gold standard for screening and diagnosis of esophageal varices (EV). Non-invasive methods for predicting EV have become a research hotspot in recent years. The aim of this study was to assess the role of non-invasive scores in predicting the presence of EV in patients with liver cirrhosis, and to determine the value of these scores in predicting the outcome of patients with cirrhosis presenting with acute variceal bleeding. Materials and Methods: A total of 386 patients with liver cirrhosis were included. The model for end-stage liver disease (MELD), aspartate aminotransferase (AST) to alanine aminotransferase (ALT) ratio (AST/ALT), AST to platelet ratio index (APRI), fibrosis-4-index (FIB-4), fibrosis index (FI), King’s Score, albumin-bilirubin (ALBI) score, and platelet-albumin-bilirubin (PALBI) score were calculated. The discriminatory capacities of the examined scores in predicting the presence of esophageal varices were tested using receiver operating characteristic (ROC) curves. Results: The ROC curve analysis showed (area under the curve) AUC values of ALBI and PALBI of 0.603, and 0.606, respectively, for the prediction of EV. APRI, MELD, PALBI, King’s, FIB-4, and ALBI scores showed statistically significant correlation with EV bleeding (p < 0.05). AUC of APRI and MELD for predicting EV bleeding were 0.662 and 0.637, respectively. The AUC value of MELD in short-term mortality was 0.761. Conclusions: ALBI and PALBI scores had modest diagnostic accuracy of EVs in liver cirrhosis. APRI and MELD can be used as a reference index for the EV bleeding, and MELD score is best associated with short-term outcome in cirrhotic patients. View Full-Text
Keywords: liver cirrhosis; esophageal varices; variceal bleeding; non-invasive scoring systems liver cirrhosis; esophageal varices; variceal bleeding; non-invasive scoring systems
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MDPI and ACS Style

Glisic, T.; Stojkovic Lalosevic, M.; Milovanovic, T.; Rankovic, I.; Stojanovic, M.; Toplicanin, A.; Aleksic, M.; Milivojevic, V.; Martinov Nestorov, J.; Lolic, I.; Popovic, D.D. Diagnostic Value of Non-invasive Scoring Systems in the Prediction of Esophageal Varices in Patients with Liver Cirrhosis—Single Center Experience. Medicina 2022, 58, 158. https://doi.org/10.3390/medicina58020158

AMA Style

Glisic T, Stojkovic Lalosevic M, Milovanovic T, Rankovic I, Stojanovic M, Toplicanin A, Aleksic M, Milivojevic V, Martinov Nestorov J, Lolic I, Popovic DD. Diagnostic Value of Non-invasive Scoring Systems in the Prediction of Esophageal Varices in Patients with Liver Cirrhosis—Single Center Experience. Medicina. 2022; 58(2):158. https://doi.org/10.3390/medicina58020158

Chicago/Turabian Style

Glisic, Tijana, Milica Stojkovic Lalosevic, Tamara Milovanovic, Ivan Rankovic, Marija Stojanovic, Aleksandar Toplicanin, Marko Aleksic, Vladimir Milivojevic, Jelena Martinov Nestorov, Iva Lolic, and Dusan D. Popovic. 2022. "Diagnostic Value of Non-invasive Scoring Systems in the Prediction of Esophageal Varices in Patients with Liver Cirrhosis—Single Center Experience" Medicina 58, no. 2: 158. https://doi.org/10.3390/medicina58020158

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