Peri-Neural Invasion Is an Important Prognostic Factor of T2N0 Oral Cancer
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Subjects Inclusion Criteria
2.2. Adjuvant Therapy after Surgery
2.3. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Characteristics | Numbers (%) | 3-Year DSS | p Value | 3-Year DFS | p Value |
---|---|---|---|---|---|
Age | 33–92 | ||||
Median:56 | |||||
≤56 | 83 (50) | 85.7% | 86.4% | ||
>56 | 83 (50) | 84.6% | p = 0.22 | 74.0% | p = 0.25 |
Gender | |||||
Male | 148 (89.2) | 85.7% | 80.1% | ||
Female | 18 (10.8) | 88.8% | p = 0.56 | 80.4% | p = 0.85 |
Grade | |||||
Well differentiated | 14 (8.4) | 100% | 84.4% | ||
Moderate differentiated | 132 (79.6) | 85.8% | 81.2% | ||
Poor differentiated | 20 (12.0) | 70.1% | p = 0.56 | 70.0% | p = 0.53 |
PNI | |||||
Positive | 24 (14.4) | 57.0% | 54.6% | ||
Negative | 142 (85.6) | 90.8% | p = 0.0006 | 84.2% | p = 0.001 |
ALI | |||||
Positive | 6 (3.6) | 50.0% | 50.0% | ||
Negative | 160 (96.4) | 87.5% | p = 0.01 | 82.2% | p = 0.0009 |
Margin | |||||
Positive | 20 (12.0) | 72.3% | 68.8% | ||
Negative | 146 (88.0) | 86.9% | p = 0.25 | 81.6% | p = 0.33 |
Adjuvant radiotherapy | |||||
Yes | 28 (16.8) | 88.2% | 92.8% | ||
No | 138 (83.2) | 83.1% | p = 0.24 | 77.5% | p = 0.11 |
Adjuvant chemotherapy | |||||
Yes | 24 (14.4) | 100% | 100% | ||
No | 142 (85.6) | 82.4% | p = 0.01 | 76.7% | p = 0.02 |
Variables | HR (95%CI) | p Value |
---|---|---|
DSS | ||
PNI | 5.02 (1.99–12.6) | p = 0.001 |
ALI | 1.79 (0.45–7.16) | p = 0.405 |
Adjuvant chemotherapy | 0.01 (0.00–5.57) | p = 0.957 |
DFS | ||
PNI | 3.92 (1.65–9.32) | p = 0.002 |
ALI | 3.23 (0.95–10.9) | p = 0.059 |
Adjuvant chemotherapy | 0.06 (0.01–0.52) | p = 0.010 |
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Cheng, C.-S.; Chen, C.-C.; Liu, Y.-C.; Wang, C.-C.; Chou, Y.-S. Peri-Neural Invasion Is an Important Prognostic Factor of T2N0 Oral Cancer. Medicina 2022, 58, 1809. https://doi.org/10.3390/medicina58121809
Cheng C-S, Chen C-C, Liu Y-C, Wang C-C, Chou Y-S. Peri-Neural Invasion Is an Important Prognostic Factor of T2N0 Oral Cancer. Medicina. 2022; 58(12):1809. https://doi.org/10.3390/medicina58121809
Chicago/Turabian StyleCheng, Chi-Sheng, Chien-Chih Chen, Yi-Chun Liu, Chen-Chi Wang, and Yu-Shu Chou. 2022. "Peri-Neural Invasion Is an Important Prognostic Factor of T2N0 Oral Cancer" Medicina 58, no. 12: 1809. https://doi.org/10.3390/medicina58121809