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Review

Immune Modulation in Critically Ill Septic Patients

1
Dipartimento di Scienze dell’ Emergenza, Anestesiologiche e della Rianimazione, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy
2
Facoltà di Medicina e Chirurgia “A. Gemelli”, Università Cattolica del Sacro Cuore, 00168 Rome, Italy
*
Author to whom correspondence should be addressed.
Academic Editors: Antonio Mirijello and Alberto Tosoni
Medicina 2021, 57(6), 552; https://doi.org/10.3390/medicina57060552
Received: 13 May 2021 / Accepted: 25 May 2021 / Published: 31 May 2021
(This article belongs to the Special Issue New Strategies for Treatment of Sepsis)
Sepsis is triggered by infection-induced immune alteration and may be theoretically improved by pharmacological and extracorporeal immune modulating therapies. Pharmacological immune modulation may have long lasting clinical effects, that may even worsen patient-related outcomes. On the other hand, extracorporeal immune modulation allows short-term removal of inflammatory mediators from the bloodstream. Although such therapies have been widely used in clinical practice, the role of immune modulation in critically ill septic patients remains unclear and little evidence supports the role of immune modulation in this clinical context. Accordingly, further research should be carried out by an evidence-based and personalized approach in order to improve the management of critically ill septic patients. View Full-Text
Keywords: sepsis; septic shock; infection; extracorporeal immune modulation; blood purification; renal replacement therapy sepsis; septic shock; infection; extracorporeal immune modulation; blood purification; renal replacement therapy
MDPI and ACS Style

Cutuli, S.L.; Carelli, S.; Grieco, D.L.; De Pascale, G. Immune Modulation in Critically Ill Septic Patients. Medicina 2021, 57, 552. https://doi.org/10.3390/medicina57060552

AMA Style

Cutuli SL, Carelli S, Grieco DL, De Pascale G. Immune Modulation in Critically Ill Septic Patients. Medicina. 2021; 57(6):552. https://doi.org/10.3390/medicina57060552

Chicago/Turabian Style

Cutuli, Salvatore L., Simone Carelli, Domenico L. Grieco, and Gennaro De Pascale. 2021. "Immune Modulation in Critically Ill Septic Patients" Medicina 57, no. 6: 552. https://doi.org/10.3390/medicina57060552

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