Next Article in Journal
Colonic Stenting in the Emergency Setting
Previous Article in Journal
Integrative Medicine and Plastic Surgery: A Synergy—Not an Antonym
Article

Brain-Derived Neurotrophic Factor and Immune Cells in Osteoarthritis, Chronic Low Back Pain, and Chronic Widespread Pain Patients: Association with Anxiety and Depression

1
Department of Rehabilitation Medicine, Hannover Medical School, Carl-Neuberg-Str.1, 30625 Hannover, Germany
2
Department of Rheumatology and Clinical Immunology, Hannover Medical School, Carl-Neuberg-Str.1, 30625 Hannover, Germany
3
Institute of Clinical Chemistry, Hannover Medical School, Carl-Neuberg-Str.1, 30625 Hannover, Germany
*
Author to whom correspondence should be addressed.
Medicina 2021, 57(4), 327; https://doi.org/10.3390/medicina57040327
Received: 19 February 2021 / Revised: 17 March 2021 / Accepted: 25 March 2021 / Published: 1 April 2021
Background and Objectives: Musculoskeletal dysfunction can induce several types of chronic pain syndromes. It is of particular interest to elucidate the pathomechanism of different forms of chronic pain. It is possible that patients who have developed chronic widespread pain (CWP) may endure different pathomechanisms as compared to those who suffer from local pain (osteoarthritis, OA) and regional pain (chronic low back pain, cLBP), especially with regard to pain regulation and its related biomediators. The aim of this study was to determine the differences in pathomechanisms among these patients by measuring pain-related biomediators, particularly brain-derived neurotrophic factor (BDNF). Additionally, subpopulations of immune cells were determined in parallel. Materials and Methods: Patients and healthy subjects (HSs) were recruited (age and gender-matched). BDNF was measured from serum samples of patients and HSs and the data of body composition parameters were recorded. Additionally, both patients and HSs were asked to fill in questionnaires related to pain intensity, anxiety, and depression. Results: Our results highlight that the levels of both free and total BDNF are significantly lower in pain patients compared to HSs, with p values of 0.041 and 0.024, respectively. The number of CD3 CD56bright natural killer (NK) cells shows significant differences between the groups. Comparing all chronic pain patients with HSs reveals a significantly lower number of CD4+ CD8+ T cells (p = 0.031), CD3 CD56bright NK cells (p = 0.049) and CD20+ CD3 cells (p = 0.007). Conclusions: To conclude, it seems that a general conformity between the pathomechanisms of different chronic pain diseases exists, although there are unique findings only in specific chronic pain patients. View Full-Text
Keywords: osteoarthritis; chronic low back pain; chronic widespread pain; BDNF; anxiety; depression; immune cells osteoarthritis; chronic low back pain; chronic widespread pain; BDNF; anxiety; depression; immune cells
Show Figures

Figure 1

MDPI and ACS Style

Dimmek, D.J.; Korallus, C.; Buyny, S.; Christoph, G.; Lichtinghagen, R.; Jacobs, R.; Nugraha, B. Brain-Derived Neurotrophic Factor and Immune Cells in Osteoarthritis, Chronic Low Back Pain, and Chronic Widespread Pain Patients: Association with Anxiety and Depression. Medicina 2021, 57, 327. https://doi.org/10.3390/medicina57040327

AMA Style

Dimmek DJ, Korallus C, Buyny S, Christoph G, Lichtinghagen R, Jacobs R, Nugraha B. Brain-Derived Neurotrophic Factor and Immune Cells in Osteoarthritis, Chronic Low Back Pain, and Chronic Widespread Pain Patients: Association with Anxiety and Depression. Medicina. 2021; 57(4):327. https://doi.org/10.3390/medicina57040327

Chicago/Turabian Style

Dimmek, Dominique J., Christoph Korallus, Sabine Buyny, Gutenbrunner Christoph, Ralf Lichtinghagen, Roland Jacobs, and Boya Nugraha. 2021. "Brain-Derived Neurotrophic Factor and Immune Cells in Osteoarthritis, Chronic Low Back Pain, and Chronic Widespread Pain Patients: Association with Anxiety and Depression" Medicina 57, no. 4: 327. https://doi.org/10.3390/medicina57040327

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop